Cytotoxic T-lymphocyte associated protein 4

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Clinical significance

Type 1 diabetes Graves' disease Hashimoto's thyroiditis Celiac disease Systemic lupus erythematosus

29 related topics

Function

Immunoglobulin superfamily Activated T cells Homologous CD28 Affinity

16 related topics

Structure

Extracellular V domain Transmembrane Cytoplasmic Alternate splice variants

15 related topics

Overview

Cluster of differentiation Protein receptor Immune checkpoint Immune responses Regulatory T cells

24 related topics

Key facts & relationships

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Aliases: CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7
Band: 2q33.2 · 1 C2|1 30.58 cM
Bgee: lymph node · appendix · buccal mucosa cell · gonad · pancreatic epithelial cell
BioGPS: More reference expression data
Chr.: Chromosome 2 (human) · Chromosome 1 (mouse)

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Structure

Extracellular
V domain Immunoglobulin V-set domain
Transmembrane Transmembrane protein
Cytoplasmic Cytoplasm
Alternate splice variants Alternative splicing
Isoforms Protein isoform
Homodimer
Disulfide bond
PI3K Phosphoinositide 3-kinase
PP2A Protein Phosphatase 2
SHP-2 PTPN11
SH3 SH3 domain
CD3 CD3 (immunology)
LAT Linker of activated T cells
PI3K

Interactions

Interact Protein-protein interaction
AP2M1
SHP-2
PPP2R5A

Advanced semantic analysis

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Cytotoxic T-lymphocyte associated protein 4

Nodes99

Edges98

Triples94

Avg. degree1.98

Density0.020202

Components1

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Cytotoxic T-lymphocyte associated protein 4

Top relations

Gene ontology · 24

Cytotoxic T-lymphocyte associated protein 4 → adaptive immune response, B cell receptor signaling pathway, cellular response to DNA damage stimulus, clathrin-coated endocytic vesicle, external side of plasma membrane, Golgi apparatus, immune response, immune system process, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of B cell proliferation, negative regulation of immune response, negative regulation of regulatory T cell differentiation, negative regulation of T cell proliferation, perinuclear region of cytoplasm, plasma membrane, positive regulation of apoptotic process, protein binding, protein complex involved in cell adhesion

Bgee · 20

Cytotoxic T-lymphocyte associated protein 4 → appendix, buccal mucosa cell, colon, esophagus, gallbladder, gonad, granulocyte, ileum, jejunum, lymph node, pancreatic ductal cell, pancreatic epithelial cell, primary oocyte, secondary oocyte, spleen, superficial temporal artery, testicle, thymus, zone of skin, zygote

RNA expression pattern · 20

Band · 2

Cytotoxic T-lymphocyte associated protein 4 → 1 C2|1 30.58 cM, 2q33.2

Chr. · 2

Cytotoxic T-lymphocyte associated protein 4 → Chromosome 1 (mouse), Chromosome 2 (human)

End · 2

Cytotoxic T-lymphocyte associated protein 4 → 203,873,965 bp, 60,954,991 bp

Aliases · 1

Cytotoxic T-lymphocyte associated protein 4 → CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4

Available structures · 1

Cytotoxic T-lymphocyte associated protein 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7

BioGPS · 1

Cytotoxic T-lymphocyte associated protein 4 → More reference expression data

Databases · 1

Cytotoxic T-lymphocyte associated protein 4 → NCBI: entry; OMA: entry

Important terminology Word statistics

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Important terminology

ctla-4 immune cells protein gene cd28 cd80 cell also bp cd86 regulatory ctla4 human function may dr chr band disease

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Cytotoxic T-lymphocyte associated protein 4	Aliases	CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Band	2q33.2	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Band	1 C2\|1 30.58 cM	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	lymph node	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	appendix	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	buccal mucosa cell	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	gonad	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	pancreatic epithelial cell	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	testicle	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	granulocyte	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	pancreatic ductal cell	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	superficial temporal artery	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	gallbladder	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	secondary oocyte	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	zygote	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	thymus	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	primary oocyte	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	spleen	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	ileum	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	zone of skin	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	jejunum	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	esophagus	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Bgee	colon	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	BioGPS	More reference expression data	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Chr.	Chromosome 2 (human)	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Chr.	Chromosome 1 (mouse)	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	Databases	NCBI: entry; OMA: entry	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	End	203,873,965 bp	1.00	infobox
Cytotoxic T-lymphocyte associated protein 4	End	60,954,991 bp	1.00	infobox

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Cytotoxic T-lymphocyte associated protein 4

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Cytotoxic T-lymphocyte associated protein 4

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Important terminology

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