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ICOS (gene)

Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene. The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on the surface of immune cells that mediate signalling between them. A surface protein, the…

Knockout phenotype, Function & Combination therapy

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Knockout phenotype

T cellsCD3IL-2Th1Th2
16 related topics

Function

T cellsICOS-LFollicular helper T (Tfh) cellsHomodimers
4 related topics

Combination therapy

IpilimumabCTLA-4C57BL/6Ligand
4 related topics

Overview

Immune checkpointGeneCD28CTLA-4
4 related topics

Key facts & relationships

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Aliases
ICOS, AILIM, CD278, CVID1, inducible T-cell co-stimulator, inducible T-cell costimulator, inducible T cell costimulator
Band
2q33.2 · 1 C2|1 30.6 cM
Bgee
lymph node · appendix · thymus · granulocyte · epithelium of nasopharynx
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Function

Knockout phenotype

Combination therapy

Advanced semantic analysis

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Map overview Semantic statistics

ICOS (gene)

Nodes33
Edges32
Triples70
Avg. degree1.94
Density0.060606
Components1

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ICOS (gene)

Top relations

Bgee · 18
ICOS (gene) → appendix, blood, bone marrow, carotid body, embryo, epithelium of nasopharynx, granulocyte, lymph node, medial ganglionic eminence, mesenteric lymph nodes, Paneth cell, spleen, subcutaneous adipose tissue, submandibular gland, superficial temporal artery, testicle, thymus, tonsil
RNA expression pattern · 18
ICOS (gene) → appendix, blood, bone marrow, carotid body, embryo, epithelium of nasopharynx, granulocyte, lymph node, medial ganglionic eminence, mesenteric lymph nodes, Paneth cell, spleen, subcutaneous adipose tissue, submandibular gland, superficial temporal artery, testicle, thymus, tonsil
Gene ontology · 14
ICOS (gene) → cell-cell adhesion, external side of plasma membrane, extracellular region, immune response, integral component of membrane, integral component of plasma membrane, membrane, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, plasma membrane, positive regulation of protein kinase B signaling, protein binding, T cell costimulation, T cell tolerance induction
Band · 2
ICOS (gene) → 1 C2|1 30.6 cM, 2q33.2
Chr. · 2
ICOS (gene) → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
ICOS (gene) → 203,961,577 bp, 61,039,479 bp
Aliases · 1
ICOS (gene) → ICOS, AILIM, CD278, CVID1, inducible T-cell co-stimulator, inducible T-cell costimulator, inducible T cell costimulator
BioGPS · 1
ICOS (gene) → More reference expression data
Databases · 1
ICOS (gene) → NCBI: entry; OMA: entry
Ensembl · 1
ICOS (gene) → ENSG00000163600

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Important terminology

icos protein bp human cells gene expressed chr band cell immune receptor chromosome location secretion surface ligand external icos- reduced

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ICOS (gene)AliasesICOS, AILIM, CD278, CVID1, inducible T-cell co-stimulator, inducible T-cell costimulator, inducible T cell costimulator1.00infobox
ICOS (gene)Band2q33.21.00infobox
ICOS (gene)Band1 C2|1 30.6 cM1.00infobox
ICOS (gene)Bgeelymph node1.00infobox
ICOS (gene)Bgeeappendix1.00infobox
ICOS (gene)Bgeethymus1.00infobox
ICOS (gene)Bgeegranulocyte1.00infobox
ICOS (gene)Bgeeepithelium of nasopharynx1.00infobox
ICOS (gene)Bgeeblood1.00infobox
ICOS (gene)Bgeetesticle1.00infobox
ICOS (gene)Bgeesuperficial temporal artery1.00infobox
ICOS (gene)Bgeebone marrow1.00infobox
ICOS (gene)Bgeetonsil1.00infobox
ICOS (gene)Bgeemesenteric lymph nodes1.00infobox
ICOS (gene)Bgeeembryo1.00infobox
ICOS (gene)BgeePaneth cell1.00infobox
ICOS (gene)Bgeespleen1.00infobox
ICOS (gene)Bgeesubcutaneous adipose tissue1.00infobox
ICOS (gene)Bgeesubmandibular gland1.00infobox
ICOS (gene)Bgeecarotid body1.00infobox
ICOS (gene)Bgeemedial ganglionic eminence1.00infobox
ICOS (gene)BioGPSMore reference expression data1.00infobox
ICOS (gene)Chr.Chromosome 2 (human)1.00infobox
ICOS (gene)Chr.Chromosome 1 (mouse)1.00infobox
ICOS (gene)DatabasesNCBI: entry; OMA: entry1.00infobox
ICOS (gene)End203,961,577 bp1.00infobox
ICOS (gene)End61,039,479 bp1.00infobox
ICOS (gene)EnsemblENSG000001636001.00infobox
ICOS (gene)Entrez298511.00infobox
ICOS (gene)External IDsOMIM: 604558; MGI: 1858745; GeneCards: ICOS1.00infobox

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