CD40

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CD40 topic overview

The analysis highlights Specific effects on cells, Interactions and Function as prominent areas in the source structure around CD40.

Related topics: 58
Source areas: 6
Connected nodes: 64
Extracted relationships: 205
Concept neighborhoods: 29
Bridge connections: 64

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Specific effects on cells · 21 topics

Interactions · 13 topics

Function · 8 topics

Overview · 7 topics

Discovery · 6 topics

CD40 as a drug target in cancer · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI
Band: 20q13.12 · 2 H3|2 85.38 cM
Bgee: lymph node · right lung · spleen · upper lobe of left lung · left ovary
BioGPS: More reference expression data
Chr.: Chromosome 20 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Cluster of differentiation
Type I transmembrane protein
Antigen-presenting cells Antigen-presenting cell
CD154
CD40L
TH cells T helper cell
Hyper-IgM immunodeficiency. Hyper IgM syndrome

Discovery

Hybridoma technology
Monoclonal antibodies Monoclonal antibody
Hematopoietic cell
Lymphocyte
B cells B cell
T cell

Function

Specific effects on cells

Interactions

CD40 as a drug target in cancer

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD40 connects Entity context

The extracted context around CD40 shows recurring relationship patterns in the source. For example, CD40 → antigen binding, apoptotic signaling pathway, B cell activation, B cell proliferation, CD40 receptor complex, cell surface, cellular calcium ion homeostasis, cellular response to erythropoietin, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to mechanical stimulus, cellular response to tumor necrosis factor, cytoplasm, defense response to protozoan, defense response to virus, enzyme binding, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space Another extracted example is CD40 → APC, B-T, BAX, CD4, CD40/CD40LG, CD40L, CD40LG, CD8, CD86/CD80, ICD, IL-12, In, MHC, Moreover CD40/CD40L, T-cell, The, This, TNF, TRAF2, TRAF3. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 64

CD40 → antigen binding, apoptotic signaling pathway, B cell activation, B cell proliferation, CD40 receptor complex, cell surface, cellular calcium ion homeostasis, cellular response to erythropoietin, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to mechanical stimulus, cellular response to tumor necrosis factor, cytoplasm, defense response to protozoan, defense response to virus, enzyme binding, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space

related to Interactions · 24

CD40 → APC, B-T, BAX, CD4, CD40/CD40LG, CD40L, CD40LG, CD8, CD86/CD80, ICD, IL-12, In, MHC, Moreover CD40/CD40L, T-cell, The, This, TNF, TRAF2, TRAF3

Bgee · 18

CD40 → appendix, ascending aorta, blood, Descending thoracic aorta, external carotid artery, gastric mucosa, internal carotid artery, left ovary, lymph node, mesenteric lymph nodes, right lung, right ovary, semi-lunar valve, spleen, tail of embryo, thymus, upper lobe of left lung, vas deferens

RNA expression pattern · 18

related to CD40 as a drug target in cancer · 17

CD40 → Abs, Agonistic, Anti-CD40, B-ALL, B-cell, Because, CD, CD40L, DCs, More, On, Over, Similarly, T-cell, The CD40, There, This

has effect · 12

CD40 → As, CD154, CD4, CD40L, Early, If, IFN-γ, IL-2, In, Th1, The, TNF

related to Hyper Ig-M immunodeficiency and CD40 · 10

CD40 → As, Currently, Hyper-IgM, Ig, IgA, IgE, IgG, IgM, In, Research

related to CD40 and drug development · 6

CD40 → B-ALL, By, Crohn's, For, On, Overall

related to Discovery · 5

CD40 → Between, CD154/CD40L, Over, The, While

related to External links · 5

CD40 → Human CD40, Human Tumor, PDB, PDBe-KB, UCSC Genome Browser

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells cell activation immune cd40l human tumor gene bp expressed receptor development antibodies differentiation including hyper-igm protein cancer antigen chr

CD40 relationships Subject–Predicate–Object triples

TTTA extracted 205 structured relationships around CD40. Examples in this analysis include CD40 → Aliases → CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule and CD40 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CD40	Aliases	CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule	1.00	infobox
CD40	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI	1.00	infobox
CD40	Band	20q13.12	1.00	infobox
CD40	Band	2 H3\|2 85.38 cM	1.00	infobox
CD40	Bgee	lymph node	1.00	infobox
CD40	Bgee	right lung	1.00	infobox
CD40	Bgee	spleen	1.00	infobox
CD40	Bgee	upper lobe of left lung	1.00	infobox
CD40	Bgee	left ovary	1.00	infobox
CD40	Bgee	Descending thoracic aorta	1.00	infobox
CD40	Bgee	right ovary	1.00	infobox
CD40	Bgee	appendix	1.00	infobox
CD40	Bgee	gastric mucosa	1.00	infobox
CD40	Bgee	ascending aorta	1.00	infobox
CD40	Bgee	mesenteric lymph nodes	1.00	infobox
CD40	Bgee	tail of embryo	1.00	infobox
CD40	Bgee	blood	1.00	infobox
CD40	Bgee	external carotid artery	1.00	infobox
CD40	Bgee	internal carotid artery	1.00	infobox
CD40	Bgee	semi-lunar valve	1.00	infobox
CD40	Bgee	thymus	1.00	infobox
CD40	Bgee	vas deferens	1.00	infobox
CD40	BioGPS	More reference expression data	1.00	infobox
CD40	Chr.	Chromosome 20 (human)	1.00	infobox
CD40	Chr.	Chromosome 2 (mouse)	1.00	infobox
CD40	Databases	NCBI: entry; OMA: entry	1.00	infobox
CD40	End	46,129,863 bp	1.00	infobox
CD40	End	164,914,868 bp	1.00	infobox
CD40	Ensembl	ENSG00000101017	1.00	infobox
CD40	Entrez	958	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD40 bring nearby vocabulary together. In this analysis, examples include Immune, Cells and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CD40
- Immune
- Cells
- Cell
- Activation
- Cd40l
- Antigen
- Role
- Development
- Expressed
- Tumor
- Signaling
- Diseases
cd40
- Immune
- Cells
- Cell
- Activation
- Cd40l
- Antigen
- Role
- Development
- Expressed
- Tumor
- Signaling
- Diseases
cluster of differentiation
- Signaling
- Activation
- Cell
- Protein
- Surface
- Syndrome
- Cells
- Development
- Hyper-igm
- Band
- Cd154
- Chromosome
antigen-presenting cells
- Tumor
- Cell
- Cd40l
- Dendritic
- Activation
- Also
- Differentiation
- Expressed
- Including
- Cd154
- Ligand
- Antigen
th cells
- Tumor
- Cell
- Cd40l
- Dendritic
- Activation
- Also
- Differentiation
- Expressed
- Including
- Cd154
- Ligand
- Antigen
monoclonal antibodies
- Monoclonal
- Response
- Cancer
- Human
- Cell
- Immune
- Signaling
- Cd40
- Band
- Chromosome
- Location
- Protein
hematopoietic cell
- Differentiation
- Immune
- Cells
- Surface
- Receptor
- Expression
- Signaling
- Also
- Expressed
- Antibodies
- Tumor
- Dendritic
b cells
- Tumor
- Cell
- Cd40l
- Dendritic
- Activation
- Also
- Differentiation
- Expressed
- Including
- Cd154
- Ligand
- Antigen

Connections between topic areas Semantic bridges

For CD40, one of the stronger structural bridges in this analysis connects CD40 with Specific effects on cells. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CD40 — Specific effects on cells · splits 43 ⟂ 22

CD40 — Interactions · splits 51 ⟂ 14

CD40 — Function · splits 56 ⟂ 9

CD40 — Overview · splits 57 ⟂ 8

CD40 — Discovery · splits 58 ⟂ 7

CD40 — CD40 as a drug target in cancer · splits 61 ⟂ 4

Map overview Semantic statistics

CD40

Nodes65

Edges64

Triples205

Avg. degree1.97

Density0.030769

Components1

Source & methodology

TTTA analyzes the structure around CD40 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Specific effects on cells, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD40 · EN edition · Analysis: TopicsToTalkAbout