Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

HER2: Standards, As a drug target & Function

Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

HER2 topic overview

The analysis highlights Standards, As a drug target and Function as prominent areas in the source structure around HER2.

Related topics
70
Source areas
8
Connected nodes
78
Extracted relationships
233
Concept neighborhoods
23
Bridge connections
78

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

As a drug target · 22 topics
Function · 12 topics
Interactions · 12 topics
Overview · 8 topics
Diagnostics · 7 topics
Clinical significance · 4 topics
Name · 3 topics
Gene · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
↗
Aliases
ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ,…
Band
17q12 · 11 61.75 cM|11 D
Bgee
right uterine tube · sural nerve · skin of leg · skin of abdomen · renal medulla
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Name

Gene

Function

Clinical significance

As a drug target

Diagnostics

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HER2 connects Entity context

The extracted context around HER2 shows recurring relationship patterns in the source. For example, HER2 → apical plasma membrane, ATP binding, basal plasma membrane, basolateral plasma membrane, cell differentiation, cell population proliferation, cell surface receptor signaling pathway, cellular response to epidermal growth factor stimulus, cellular response to growth factor stimulus, cytoplasm, cytoplasmic vesicle, cytosol, development of the heart, endosome membrane, enzyme linked receptor protein signaling pathway, ErbB-3 class receptor binding, ERBB2 signaling pathway, growth factor binding, identical protein binding, integral component of membrane Another extracted example is HER2 → colon, crypt of lieberkuhn of small intestine, esophagus, Eustachian tube, intestinal villus, left colon, left lobe of thyroid gland, lip, middle ear, minor salivary glands, mucosa of transverse colon, olfactory zone of nasal mucosa, oral mucosa, renal medulla, right kidney, right lobe of thyroid gland, right uterine tube, skin of abdomen, skin of leg, sural nerve. Use these groups to spot repeated connection types before inspecting the individual relationships.

HER2

Top relations

Gene ontology · 86
HER2 → apical plasma membrane, ATP binding, basal plasma membrane, basolateral plasma membrane, cell differentiation, cell population proliferation, cell surface receptor signaling pathway, cellular response to epidermal growth factor stimulus, cellular response to growth factor stimulus, cytoplasm, cytoplasmic vesicle, cytosol, development of the heart, endosome membrane, enzyme linked receptor protein signaling pathway, ErbB-3 class receptor binding, ERBB2 signaling pathway, growth factor binding, identical protein binding, integral component of membrane
Bgee · 20
HER2 → colon, crypt of lieberkuhn of small intestine, esophagus, Eustachian tube, intestinal villus, left colon, left lobe of thyroid gland, lip, middle ear, minor salivary glands, mucosa of transverse colon, olfactory zone of nasal mucosa, oral mucosa, renal medulla, right kidney, right lobe of thyroid gland, right uterine tube, skin of abdomen, skin of leg, sural nerve
RNA expression pattern · 20
HER2 → colon, crypt of lieberkuhn of small intestine, esophagus, Eustachian tube, intestinal villus, left colon, left lobe of thyroid gland, lip, middle ear, minor salivary glands, mucosa of transverse colon, olfactory zone of nasal mucosa, oral mucosa, renal medulla, right kidney, right lobe of thyroid gland, right uterine tube, skin of abdomen, skin of leg, sural nerve
related to External links · 18
HER2 → AACR Cancer Concepts Factsheet, Breast Cancer Patients, HER2 Positive WomenHerceptinR, HER2Breast Friends, Herceptin Resistance Database, Human Receptor, Life Network, Medicine Medical Subject Headings, MeSH, National Library, PDB, PDBe-KB, Rep, Resistance, Sci, South African Breast Cancer, Support Forum, Understanding Mechanism
related to As a drug target · 11
HER2 → An, Another, FDA, HER2-positive, HER3, Herceptin, June, One, Pertuzumab, Randomized, Trastuzumab
related to Fluorescence in situ hybridisation · 11
HER2 → Cells, CEP17, FISH, Hence, HER2/CEP17, It, One, Overlapping, The, This, Two
related to Cancer · 7
HER2 → Amplification, ERBB2, GRB7, HER2-positive, Over-expression, The, The ERBB2
related to Name · 7
HER2 → EGFR, ErbB, ErbB-2, HER1, Molecular, Neu, The Neu
related to Function · 6
HER2 → All, Dimerisation, ErbB, Notably, One, The ErbB
related to Serum · 5
HER2 → ELISA, However, Measurement, Results, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer receptor erbb trastuzumab breast human gene protein also kinase chromosome 17 bp erbb2 cell growth cells patients epidermal factor

HER2 relationships Subject–Predicate–Object triples

TTTA extracted 233 structured relationships around HER2. Examples in this analysis include HER2 → 2.7.10.1 → ↗ and HER2 → Aliases → ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HER22.7.10.1↗1.00infobox
HER2AliasesERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 21.00infobox
HER2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ,…1.00infobox
HER2Band17q121.00infobox
HER2Band11 61.75 cM|11 D1.00infobox
HER2Bgeeright uterine tube1.00infobox
HER2Bgeesural nerve1.00infobox
HER2Bgeeskin of leg1.00infobox
HER2Bgeeskin of abdomen1.00infobox
HER2Bgeerenal medulla1.00infobox
HER2Bgeeminor salivary glands1.00infobox
HER2Bgeeright lobe of thyroid gland1.00infobox
HER2Bgeeolfactory zone of nasal mucosa1.00infobox
HER2Bgeemucosa of transverse colon1.00infobox
HER2Bgeeleft lobe of thyroid gland1.00infobox
HER2Bgeelip1.00infobox
HER2Bgeeintestinal villus1.00infobox
HER2Bgeemiddle ear1.00infobox
HER2BgeeEustachian tube1.00infobox
HER2Bgeeoral mucosa1.00infobox
HER2Bgeeesophagus1.00infobox
HER2Bgeecolon1.00infobox
HER2Bgeecrypt of lieberkuhn of small intestine1.00infobox
HER2Bgeeright kidney1.00infobox
HER2Bgeeleft colon1.00infobox
HER2BioGPSMore reference expression data1.00infobox
HER2Chr.Chromosome 17 (human)1.00infobox
HER2Chr.Chromosome 11 (mouse)1.00infobox
HER2DatabasesNCBI: entry; OMA: entry1.00infobox
HER2End39,730,426 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HER2 bring nearby vocabulary together. In this analysis, examples include Cancer, Breast and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HER2
    • Cancer
    • Breast
    • Cell
    • Receptor
    • Trastuzumab
    • Expression
    • Signal
    • Patients
    • Protein
    • Cancers
    • Growth
    • Receptors
  • her2
    • Cancer
    • Breast
    • Cell
    • Receptor
    • Trastuzumab
    • Expression
    • Signal
    • Patients
    • Protein
    • Cancers
    • Growth
    • Receptors
  • protein
    • Growth
    • Cell
    • Epidermal
    • Factor
    • Important
    • Signaling
    • Receptor
    • Erbb2
    • Signal
    • Gene
    • Human
    • Erbb
  • gene
    • Chromosome
    • Bp
    • Chr
    • Kinase
    • Human
    • Band
    • Immunohistochemistry
    • Tyrosine
    • Receptor
    • Signal
    • Also
    • Protein
  • epidermal growth factor receptor (her/egfr/erbb) family
    • Factor
    • Growth
    • Family
    • Human
    • Receptor
    • Epidermal
    • Erbb
    • Protein
    • Signaling
    • Signal
    • Tyrosine
    • Kinase
  • breast cancer
    • Breast
    • Cancer
    • Patients
    • Her2
    • Cancers
    • Therapy
    • Target
    • Important
    • Over-expression
    • Amplification
    • Cell
    • Cells
  • receptor tyrosine kinases
    • Kinase
    • Bp
    • Chr
    • Signaling
    • Erbb2
    • Signal
    • Receptor
    • Tyrosine
    • Chromosome
    • Also
    • Gene
    • Human
  • mitogen-activated protein kinase
    • Tyrosine
    • Erbb-2
    • Erbb2
    • Growth
    • Signal
    • Receptor
    • Gene
    • Human
    • Protein
    • Cell
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For HER2, one of the stronger structural bridges in this analysis connects HER2 with As a drug target. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HER2 — As a drug target · splits 56 ⟂ 23
HER2 — Function · splits 66 ⟂ 13
HER2 — Interactions · splits 66 ⟂ 13
HER2 — Overview · splits 70 ⟂ 9
HER2 — Diagnostics · splits 71 ⟂ 8
HER2 — Clinical significance · splits 74 ⟂ 5
HER2 — Name · splits 75 ⟂ 4
HER2 — Gene · splits 76 ⟂ 3

Map overview Semantic statistics

HER2

Nodes79
Edges78
Triples233
Avg. degree1.97
Density0.025316
Components1

Source & methodology

TTTA analyzes the structure around HER2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, As a drug target & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HER2 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.