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BTLA

B- and T-lymphocyte attenuator or BTLA (also known as cluster of differentiation 272 or CD272) is a protein that belongs to the CD28 immunoglobulin superfamily (IgSF) which is encoded by the BTLA gene located on the 3rd human chromosome. BTLA was first discovered in 2003 as an inhibitor of Th1 expansion and it became the 3rd member of the CD28 IgSF.…

Expression, Function & Clinical significance

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Aliases
BTLA, BTLA1, CD272, B and T lymphocyte associated
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AW2
Band
3q13.2 · 16|16 B5
Bgee
lymph node · appendix · testicle · granulocyte · spleen
BioGPS
n/a
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

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Overview

Expression

Structure

Function

Clinical significance

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Map overview Semantic statistics

BTLA

Nodes51
Edges50
Triples155
Avg. degree1.96
Density0.039216
Components1

How this topic connects Entity context

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BTLA

Top relations

Bgee · 17
BTLA → appendix, blood, bone marrow, bone marrow cell, embryo, epithelium of colon, gonad, granulocyte, lymph node, mesenteric lymph nodes, mucosa of transverse colon, primitive streak, spleen, subcutaneous adipose tissue, submandibular gland, testicle, thymus
RNA expression pattern · 17
BTLA → appendix, blood, bone marrow, bone marrow cell, embryo, epithelium of colon, gonad, granulocyte, lymph node, mesenteric lymph nodes, mucosa of transverse colon, primitive streak, spleen, subcutaneous adipose tissue, submandibular gland, testicle, thymus
related to Function · 16
BTLA → As, CD160, Considering, Grb-2, HVEM, Interaction, ITIM, LIGHT, On, PI3K, SHP-1, SHP-2, Taken, The, Therefore, TNFSF14
related to External links · 14
BTLA → Human BTLA, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Q7Z6A9, T-lymphocyte, This, UCSC Genome Browser, UniProt, United States National Library
related to Infectious diseases · 13
BTLA → As, CD4, CD8, During, Furthermore, However, HVEM, IL-9, Mycobacterium, Similar, Strongyloides, This, When
related to Tumors · 11
BTLA → CD4, CD8, Even, For, Hence, However, IFN-γ, In, Similarly, Therefore, This
Gene ontology · 10
BTLA → adaptive immune response, immune response-regulating cell surface receptor signaling pathway, immune system process, integral component of membrane, integral component of plasma membrane, membrane, plasma membrane, protein binding, signaling receptor activity, T cell costimulation
related to T cell · 10
BTLA → Both BTLA, CD8, For, Furthermore, However, HVEM, PD-1, This, Treg, When
related to Structure · 8
BTLA → CTLA-4, Grb-2, It, ITIM, ITSM, PD-1, The, Therefore
related to Expression · 7
BTLA → Among, DCs, For, If, In, NKT, On

Important terminology Word statistics

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Important terminology

cells hvem expression cell human also bp cd8 chromosome gene chr band function interaction seems however protein location instance connected

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BTLAAliasesBTLA, BTLA1, CD272, B and T lymphocyte associated1.00infobox
BTLAAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2AW21.00infobox
BTLABand3q13.21.00infobox
BTLABand16|16 B51.00infobox
BTLABgeelymph node1.00infobox
BTLABgeeappendix1.00infobox
BTLABgeetesticle1.00infobox
BTLABgeegranulocyte1.00infobox
BTLABgeespleen1.00infobox
BTLABgeebone marrow cell1.00infobox
BTLABgeeblood1.00infobox
BTLABgeemucosa of transverse colon1.00infobox
BTLABgeegonad1.00infobox
BTLABgeeepithelium of colon1.00infobox
BTLABgeemesenteric lymph nodes1.00infobox
BTLABgeesubcutaneous adipose tissue1.00infobox
BTLABgeesubmandibular gland1.00infobox
BTLABgeeprimitive streak1.00infobox
BTLABgeethymus1.00infobox
BTLABgeeembryo1.00infobox
BTLABgeebone marrow1.00infobox
BTLABioGPSn/a1.00infobox
BTLAChr.Chromosome 3 (human)1.00infobox
BTLAChr.Chromosome 16 (mouse)1.00infobox
BTLADatabasesNCBI: entry; OMA: entry1.00infobox
BTLAEnd112,499,472 bp1.00infobox
BTLAEnd45,078,033 bp1.00infobox
BTLAEnsemblENSG000001862651.00infobox
BTLAEntrez1518881.00infobox
BTLAExternal IDsOMIM: 607925; MGI: 2658978; GeneCards: BTLA1.00infobox

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