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Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene.
The analysis highlights Function, Interactions and Structure as prominent areas in the source structure around APAF1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around APAF1 shows recurring relationship patterns in the source. For example, APAF1 → activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, ADP binding, ageing, apoptosome, apoptotic process, apoptotic signaling pathway, ATP binding, brain development, cardiac muscle cell apoptotic process, cell differentiation, cellular response to transforming growth factor beta stimulus, cysteine-type endopeptidase activator activity involved in apoptotic process, cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, forebrain development, glial cell apoptotic process Another extracted example is APAF1 → Achilles tendon, blood, bone marrow cell, dermis, epithelium of colon, ganglionic eminence, gastrula, granulocyte, ileum, jejunum, migratory enteric neural crest cell, monocyte, otic vesicle, stroma of bone marrow, testicle, trabecular bone, ureter, vas deferens, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
human bp gene chr band protein chromosome 12 apoptosome apoptotic factor location caspase-9 mouse binding activating function search 735 433
TTTA extracted 111 structured relationships around APAF1. Examples in this analysis include APAF1 → Aliases → APAF1, APAF-1, CED4, apoptotic peptidase activating factor 1 and APAF1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| APAF1 | Aliases | APAF1, APAF-1, CED4, apoptotic peptidase activating factor 1 | 1.00 | infobox |
| APAF1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT | 1.00 | infobox |
| APAF1 | Band | 12q23.1 | 1.00 | infobox |
| APAF1 | Band | 10 C2|10 45.47 cM | 1.00 | infobox |
| APAF1 | Bgee | monocyte | 1.00 | infobox |
| APAF1 | Bgee | ventricular zone | 1.00 | infobox |
| APAF1 | Bgee | blood | 1.00 | infobox |
| APAF1 | Bgee | bone marrow cell | 1.00 | infobox |
| APAF1 | Bgee | ganglionic eminence | 1.00 | infobox |
| APAF1 | Bgee | epithelium of colon | 1.00 | infobox |
| APAF1 | Bgee | granulocyte | 1.00 | infobox |
| APAF1 | Bgee | Achilles tendon | 1.00 | infobox |
| APAF1 | Bgee | trabecular bone | 1.00 | infobox |
| APAF1 | Bgee | testicle | 1.00 | infobox |
| APAF1 | Bgee | dermis | 1.00 | infobox |
| APAF1 | Bgee | migratory enteric neural crest cell | 1.00 | infobox |
| APAF1 | Bgee | ureter | 1.00 | infobox |
| APAF1 | Bgee | jejunum | 1.00 | infobox |
| APAF1 | Bgee | vas deferens | 1.00 | infobox |
| APAF1 | Bgee | otic vesicle | 1.00 | infobox |
| APAF1 | Bgee | stroma of bone marrow | 1.00 | infobox |
| APAF1 | Bgee | gastrula | 1.00 | infobox |
| APAF1 | Bgee | ileum | 1.00 | infobox |
| APAF1 | BioGPS | More reference expression data | 1.00 | infobox |
| APAF1 | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| APAF1 | Chr. | Chromosome 10 (mouse) | 1.00 | infobox |
| APAF1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| APAF1 | End | 98,735,433 bp | 1.00 | infobox |
| APAF1 | End | 91,082,770 bp | 1.00 | infobox |
| APAF1 | Ensembl | ENSG00000120868 | 1.00 | infobox |
The concept neighborhoods around APAF1 bring nearby vocabulary together. In this analysis, examples include Apoptotic, Factor and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For APAF1, one of the stronger structural bridges in this analysis connects APAF1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around APAF1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — APAF1 · EN edition · Analysis: TopicsToTalkAbout