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Apoptosome

The apoptosome is a quaternary protein structure formed in the process of apoptosis. It is formed by the release of cytochrome c from the mitochondrion responses to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can differ from DNA damage or viral infection to developmental signals for instance like those leading to the…

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Overview

History

Structure

Non-human organisms

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Research areas

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Map overview Semantic statistics

Apoptosome

Nodes58
Edges57
Triples107
Avg. degree1.97
Density0.034483
Components1

How this topic connects Entity context

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Apoptosome

Top relations

related to Structure · 26
Apoptosome → Acehan, Activation, ADP, Apaf-1, ATP/dATP, C-terminal, CARD, Cytochrome, During, EM, HD2, Helical Domain, High-resolution, In, Its, Mda, N-terminus, Once, Recruitment Domain, The
related to Mutations in the apoptosome pathway · 21
Apoptosome → Acute, Alzheimer’s, Another, Apaf-1, Apaf-1-ALT, Apoptosis, As, BAK, BAX, BCL-2, Both, HD1, However, Huntington’s, In Helicobacter, Increased, Many, Parkinson’s, Reduced, This
related to history · 15
Apoptosome → An, APAF-1, Apoptosomes, ATP, B-cell, Bcl-2, Bcl-XL, Chemistry, Finally, In, Secondly, The, The Journal, This, Yoshihide Tsujimoto’s
related to Detailed structural features · 11
Apoptosome → Apoptsome, CARD, HD1, HD2, NBD, NOD, The, These, This, Walker, WHD
related to Active action · 9
Apoptosome → Although, Caspase-9, In, It, Reidl, Salvasen, The, There, This
related to New potential targets for molecular therapy · 6
Apoptosome → Apaf-1/caspase-9, Due, For, It, One, The
related to Cancer therapy · 5
Apoptosome → External, Inhibition, Several, The, Therefore
related to Initiation · 5
Apoptosome → Apaf-1, Apoptosis, PCD, The, This
related to Non-human organisms · 4
Apoptosome → CED-4, Dark, PDB, The
is a · 2
Apoptosome → protein complex assembled around the adapter protein Apaf-1 during mitochondria-mediated apoptosis, quaternary protein structure formed in the process of apoptosis

Important terminology Word statistics

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Important terminology

apaf-1 apoptosis cytochrome caspase-9 death complex domain cell cells protein procaspase-9 bcl-2 domains cancer form atp structure proteins card binds

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Apoptosomeis aquaternary protein structure formed in the process of apoptosis0.90text
Apoptosomeis aprotein complex assembled around the adapter protein Apaf-1 during mitochondria-mediated apoptosis0.90text
human leukemia cellsinstance ofStudies explored its role in conditions0.80text
ovarian cancerinstance ofStudies explored its role in conditions0.80text
viral infectionsinstance ofStudies explored its role in conditions0.80text
Apoptosomerelated to Active actionThis0.60section
Apoptosomerelated to Active actionCaspase-90.60section
Apoptosomerelated to Active actionAlthough0.60section
Apoptosomerelated to Active actionThere0.60section
Apoptosomerelated to Active actionThe0.60section
Apoptosomerelated to Active actionReidl0.60section
Apoptosomerelated to Active actionSalvasen0.60section

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    Min side: 3
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