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ZBP1

Z-DNA-binding protein 1 (also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) is an intracellular protein in mammals that can activate an innate immune pathways to suppress the viral infection. ZENB1 senses left-handed (Z-form) double-helical Z-DNA and Z-RNA, which are pathogen-associated molecular patterns (PAMPs). It…

History, Function and role in disease & Overview

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Aliases
ZBP1, C20orf183, DAI, DLM-1, DLM1, Z-DNA binding protein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4M, 2LNB, 3EYI, 4KA4
Band
20q13.31 · 2|2 H3
Bgee
granulocyte · buccal mucosa cell · blood · spleen · monocyte
BioGPS
More reference expression data
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

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Overview

History

Structure

Function and role in disease

Z-DNA and Z-RNA binding

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Map overview Semantic statistics

ZBP1

Nodes49
Edges48
Triples135
Avg. degree1.96
Density0.040816
Components1

How this topic connects Entity context

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ZBP1

Top relations

related to Z-DNA and Z-RNA binding · 19
ZBP1 → D3, DLM1, DNA, However, IAV, Influenza, It, N-terminus, Once ZBP1, Since DNA, The, Viral, Viral DNA, Virus, Z-DNA, Z-DNA-binding, Z-form RNAs, Zα, Zβ
Bgee · 17
ZBP1 → appendix, blood, bone marrow cell, buccal mucosa cell, duodenum, gallbladder, granulocyte, intestinal villus, jejunum, lymph node, mesenteric lymph nodes, monocyte, mucous cell of stomach, rectum, spleen, subcutaneous adipose tissue, thymus
RNA expression pattern · 17
ZBP1 → appendix, blood, bone marrow cell, buccal mucosa cell, duodenum, gallbladder, granulocyte, intestinal villus, jejunum, lymph node, mesenteric lymph nodes, monocyte, mucous cell of stomach, rectum, spleen, subcutaneous adipose tissue, thymus
Gene ontology · 15
ZBP1 → biological process, cytoplasm, cytosol, DNA binding, double-stranded RNA adenosine deaminase activity, identical protein binding, immune system process, innate immune response, left-handed Z-DNA binding, nucleus, positive regulation of type I interferon production, positive regulation of type I interferon-mediated signaling pathway, protein binding, regulation of type I interferon production, RNA binding
related to Function and role in disease · 15
ZBP1 → CBL0137, Following, IAV, ICB, IFN, In, NLRP3, PANoptosis, PANoptosomes, PRRs, Recent, RIPKs, ZBP1-ADAR1, ZBP1-mediated, ZBP1-PANoptosome
related to Structure · 14
ZBP1 → At, Both Zα, N-terminus, RHIM, RHIM1, RHIM2, SD, The, The C-terminal, Z-NA, Z-nucleic, Z-RNA/DNA, Zα1, Zα2
related to history · 13
ZBP1 → DNA, Experiments, Further, However, It, RHIM, RIPK, RIPK1, RIPK3, This, Z-NA, ZBP1's, Zbp1-deficient
Band · 2
ZBP1 → 20q13.31, 2|2 H3
Chr. · 2
ZBP1 → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
ZBP1 → 173,060,716 bp, 57,620,576 bp

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Important terminology

protein cell human dna death panoptosis z-dna viral infection bp binding immune virus role innate chr band domains iav gene

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ZBP1AliasesZBP1, C20orf183, DAI, DLM-1, DLM1, Z-DNA binding protein 11.00infobox
ZBP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L4M, 2LNB, 3EYI, 4KA41.00infobox
ZBP1Band20q13.311.00infobox
ZBP1Band2|2 H31.00infobox
ZBP1Bgeegranulocyte1.00infobox
ZBP1Bgeebuccal mucosa cell1.00infobox
ZBP1Bgeeblood1.00infobox
ZBP1Bgeespleen1.00infobox
ZBP1Bgeemonocyte1.00infobox
ZBP1Bgeelymph node1.00infobox
ZBP1Bgeebone marrow cell1.00infobox
ZBP1Bgeeappendix1.00infobox
ZBP1Bgeerectum1.00infobox
ZBP1Bgeegallbladder1.00infobox
ZBP1Bgeemucous cell of stomach1.00infobox
ZBP1Bgeejejunum1.00infobox
ZBP1Bgeethymus1.00infobox
ZBP1Bgeeintestinal villus1.00infobox
ZBP1Bgeeduodenum1.00infobox
ZBP1Bgeesubcutaneous adipose tissue1.00infobox
ZBP1Bgeemesenteric lymph nodes1.00infobox
ZBP1BioGPSMore reference expression data1.00infobox
ZBP1Chr.Chromosome 20 (human)1.00infobox
ZBP1Chr.Chromosome 2 (mouse)1.00infobox
ZBP1DatabasesNCBI: entry; OMA: entry1.00infobox
ZBP1End57,620,576 bp1.00infobox
ZBP1End173,060,716 bp1.00infobox
ZBP1EnsemblENSG000001242561.00infobox
ZBP1Entrez810301.00infobox
ZBP1External IDsOMIM: 606750; MGI: 1927449; GeneCards: ZBP11.00infobox

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