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AXIN1: Function, Interactions & Structure

Axin-1 is a protein that in humans is encoded by the AXIN1 gene.

Language: English [EN]
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AXIN1 topic overview

The analysis highlights Function, Interactions and Structure as prominent areas in the source structure around AXIN1.

Related topics
33
Source areas
4
Connected nodes
37
Extracted relationships
174
Concept neighborhoods
11
Bridge connections
37

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 14 topics
Interactions · 12 topics
Structure · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
AXIN1, AXIN, PPP1R49, axin 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU1
Band
16p13.3 · 17 A3.3|17 13.07 cM
Bgee
granulocyte · mucosa of transverse colon · right hemisphere of cerebellum · gastrocnemius muscle · skin of leg
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How AXIN1 connects Entity context

The extracted context around AXIN1 shows recurring relationship patterns in the source. For example, AXIN1 → activation of protein kinase activity, apoptotic process, armadillo repeat domain binding, axial mesoderm formation, beta-catenin binding, beta-catenin destruction complex, beta-catenin destruction complex assembly, beta-catenin destruction complex disassembly, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation, cell periphery, cytoplasm, cytoplasmic microtubule organization, cytoplasmic vesicle, cytosol, determination of left/right symmetry, embryonic eye morphogenesis, embryonic skeletal joint morphogenesis, enzyme binding, forebrain anterior/posterior pattern specification Another extracted example is AXIN1 → blood, corneal stroma, epiblast, gastrocnemius muscle, genital tubercle, granulocyte, Ileal epithelium, monocyte, mononuclear cell, mucosa of transverse colon, Paneth cell, popliteal artery, right hemisphere of cerebellum, skin of abdomen, skin of leg, tail of embryo, thymus, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

AXIN1

Top relations

Gene ontology · 60
AXIN1 → activation of protein kinase activity, apoptotic process, armadillo repeat domain binding, axial mesoderm formation, beta-catenin binding, beta-catenin destruction complex, beta-catenin destruction complex assembly, beta-catenin destruction complex disassembly, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation, cell periphery, cytoplasm, cytoplasmic microtubule organization, cytoplasmic vesicle, cytosol, determination of left/right symmetry, embryonic eye morphogenesis, embryonic skeletal joint morphogenesis, enzyme binding, forebrain anterior/posterior pattern specification
Bgee · 19
AXIN1 → blood, corneal stroma, epiblast, gastrocnemius muscle, genital tubercle, granulocyte, Ileal epithelium, monocyte, mononuclear cell, mucosa of transverse colon, Paneth cell, popliteal artery, right hemisphere of cerebellum, skin of abdomen, skin of leg, tail of embryo, thymus, ventricular zone, zygote
RNA expression pattern · 19
AXIN1 → blood, corneal stroma, epiblast, gastrocnemius muscle, genital tubercle, granulocyte, Ileal epithelium, monocyte, mononuclear cell, mucosa of transverse colon, Paneth cell, popliteal artery, right hemisphere of cerebellum, skin of abdomen, skin of leg, tail of embryo, thymus, ventricular zone, zygote
related to Function · 18
AXIN1 → APC, AXIN1-truncating, AXIN2, Consistently, CTNNB1, DIX, G-protein, Importantly, MMTV, Mutation, Mutations, RGS, The, The AXIN, This, Thus AXIN1, Two, WNT
related to Structure · 15
AXIN1 → Adenomatous, Biophysical, BRCA1, C-terminal DIX, CBP, CREB-binding, GSK3, IDPs, Intrinsically Disordered Proteins, Large WNT-downregulating, Many, RGS, The, The N-terminal RGS, Wnt
related to Interactions · 10
AXIN1 → APC, CSNK1A1, CSNK1E, CTNNB1, DVL1, GSK3B, LRP5, MAP3K1, PPP2R5A, RNF43
related to External links · 8
AXIN1 → Axin-1, Human AXIN1, O15169, Overview, PDB, PDBe-KB, UCSC Genome Browser, UniProt
Band · 2
AXIN1 → 16p13.3, 17 A3.3|17 13.07 cM
Chr. · 2
AXIN1 → Chromosome 16 (human), Chromosome 17 (mouse)
End · 2
AXIN1 → 26,414,785 bp, 352,723 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein human bp chr band chromosome 16 location β-catenin signaling domain wnt mutations mouse axin complex kinase function external

AXIN1 relationships Subject–Predicate–Object triples

TTTA extracted 174 structured relationships around AXIN1. Examples in this analysis include AXIN1 → Aliases → AXIN1, AXIN, PPP1R49, axin 1 and AXIN1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
AXIN1AliasesAXIN1, AXIN, PPP1R49, axin 11.00infobox
AXIN1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU11.00infobox
AXIN1Band16p13.31.00infobox
AXIN1Band17 A3.3|17 13.07 cM1.00infobox
AXIN1Bgeegranulocyte1.00infobox
AXIN1Bgeemucosa of transverse colon1.00infobox
AXIN1Bgeeright hemisphere of cerebellum1.00infobox
AXIN1Bgeegastrocnemius muscle1.00infobox
AXIN1Bgeeskin of leg1.00infobox
AXIN1Bgeemononuclear cell1.00infobox
AXIN1Bgeemonocyte1.00infobox
AXIN1Bgeeskin of abdomen1.00infobox
AXIN1Bgeeblood1.00infobox
AXIN1Bgeepopliteal artery1.00infobox
AXIN1BgeeIleal epithelium1.00infobox
AXIN1Bgeetail of embryo1.00infobox
AXIN1Bgeeventricular zone1.00infobox
AXIN1Bgeegenital tubercle1.00infobox
AXIN1Bgeeepiblast1.00infobox
AXIN1Bgeezygote1.00infobox
AXIN1BgeePaneth cell1.00infobox
AXIN1Bgeecorneal stroma1.00infobox
AXIN1Bgeethymus1.00infobox
AXIN1BioGPSMore reference expression data1.00infobox
AXIN1Chr.Chromosome 16 (human)1.00infobox
AXIN1Chr.Chromosome 17 (mouse)1.00infobox
AXIN1DatabasesNCBI: entry; OMA: entry1.00infobox
AXIN1End352,723 bp1.00infobox
AXIN1End26,414,785 bp1.00infobox
AXIN1EnsemblENSG000001031261.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around AXIN1 bring nearby vocabulary together. In this analysis, examples include Axin, Gene and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • AXIN1
    • Axin
    • Gene
    • Location
    • Human
    • Function
    • Search
    • Domain
    • Kinase
    • Rgs
    • Signaling
    • Chromosome
    • Bp
  • axin1
    • Axin
    • Gene
    • Location
    • Human
    • Function
    • Search
    • Domain
    • Kinase
    • Rgs
    • Signaling
    • Chromosome
    • Bp
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • A3
    • End
    • Function
    • Mouse
    • Search
    • Axin
    • Band
  • wnt
    • Domain
    • Rgs
    • Signaling
    • A3
    • End
    • Function
    • Mouse
    • O15169
    • Protein
    • Search
    • Uniprot
    • Axin
  • function
    • Search
    • Chromosome
    • Location
    • Bp
    • Chr
    • A3
    • End
    • Human
    • Mouse
    • O15169
    • Pdb
    • Uniprot
  • regulator of g-protein signaling (rgs) domain
    • Rgs
    • Kinase
    • Wnt
    • End
    • Function
    • Mouse
    • O15169
    • Search
    • Uniprot
    • Disordered
    • Intrinsically
    • Proteins
  • protein
    • Proteins
    • Signaling
    • Wnt
    • O15169
    • Search
    • Uniprot
    • Disordered
    • Intrinsically
    • Missense
    • Rgs
    • Mutations
  • creb-binding protein
    • Proteins
    • Signaling
    • Wnt
    • O15169
    • Search
    • Uniprot
    • Disordered
    • Intrinsically
    • Missense
    • Rgs
    • Mutations

Connections between topic areas Semantic bridges

For AXIN1, one of the stronger structural bridges in this analysis connects AXIN1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AXIN1Function · splits 23 ⟂ 15
AXIN1Interactions · splits 25 ⟂ 13
AXIN1Structure · splits 32 ⟂ 6
AXIN1Overview · splits 35 ⟂ 3

Map overview Semantic statistics

AXIN1

Nodes38
Edges37
Triples174
Avg. degree1.95
Density0.052632
Components1

Source & methodology

TTTA analyzes the structure around AXIN1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — AXIN1 · EN edition · Analysis: TopicsToTalkAbout

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