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TAB1: Function, Interactions & Overview

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene.

Language: English [EN]
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TAB1 topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around TAB1.

Related topics
26
Source areas
3
Connected nodes
29
Extracted relationships
115
Concept neighborhoods
12
Bridge connections
29

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 14 topics
Interactions · 10 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TAB1, 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L53, 4O91, 5DIY, 5JGA, 5JGD
Band
22q13.1 · 15|15 E1
Bgee
parotid gland · lateral nuclear group of thalamus · ventricular zone · right hemisphere of cerebellum · sural nerve
BioGPS
More reference expression data
Chr.
Chromosome 22 (human) · Chromosome 15 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TAB1 connects Entity context

The extracted context around TAB1 shows recurring relationship patterns in the source. For example, TAB1 → aorta development, cardiac septum development, catalytic activity, coronary vasculature development, cytosol, endosome membrane, enzyme activator activity, Fc-epsilon receptor signaling pathway, heart morphogenesis, I-kappaB kinase/NF-kappaB signaling, in utero embryonic development, interleukin-1-mediated signaling pathway, JNK cascade, kinase activator activity, lung development, mitogen-activated protein kinase p38 binding, MyD88-dependent toll-like receptor signaling pathway, nuclear speck, nucleotide-binding oligomerization domain containing signaling pathway, nucleus Another extracted example is TAB1 → apex of heart, external carotid artery, granulocyte, internal carotid artery, lateral nuclear group of thalamus, lip, muscle of thigh, neural layer of retina, otic vesicle, parotid gland, right frontal lobe, right hemisphere of cerebellum, right kidney, right ventricle, saccule, Skeletal muscle tissue of rectus abdominis, subthalamic nucleus, sural nerve, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

TAB1

Top relations

Gene ontology · 31
TAB1 → aorta development, cardiac septum development, catalytic activity, coronary vasculature development, cytosol, endosome membrane, enzyme activator activity, Fc-epsilon receptor signaling pathway, heart morphogenesis, I-kappaB kinase/NF-kappaB signaling, in utero embryonic development, interleukin-1-mediated signaling pathway, JNK cascade, kinase activator activity, lung development, mitogen-activated protein kinase p38 binding, MyD88-dependent toll-like receptor signaling pathway, nuclear speck, nucleotide-binding oligomerization domain containing signaling pathway, nucleus
Bgee · 19
TAB1 → apex of heart, external carotid artery, granulocyte, internal carotid artery, lateral nuclear group of thalamus, lip, muscle of thigh, neural layer of retina, otic vesicle, parotid gland, right frontal lobe, right hemisphere of cerebellum, right kidney, right ventricle, saccule, Skeletal muscle tissue of rectus abdominis, subthalamic nucleus, sural nerve, ventricular zone
RNA expression pattern · 19
TAB1 → apex of heart, external carotid artery, granulocyte, internal carotid artery, lateral nuclear group of thalamus, lip, muscle of thigh, neural layer of retina, otic vesicle, parotid gland, right frontal lobe, right hemisphere of cerebellum, right kidney, right ventricle, saccule, Skeletal muscle tissue of rectus abdominis, subthalamic nucleus, sural nerve, ventricular zone
related to Function · 15
TAB1 → Alternatively, C-terminal, It, MAP, MAP3K7/TAK1, MAPK14, MAPK14/p38alpha, MAPKK, N-terminus, TAK1, TGF, TGF-beta, The, This, WNT-1
related to Interactions · 8
TAB1 → MAP3K1, MAP3K7, MAP3K7IP2, MAP3K7IP3, MAPK14, Mothers, TRAF6, XIAP
Band · 2
TAB1 → 15|15 E1, 22q13.1
Chr. · 2
TAB1 → Chromosome 15 (mouse), Chromosome 22 (human)
End · 2
TAB1 → 39,437,060 bp, 80,045,908 bp
Aliases · 1
TAB1 → TAB1, 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Available structures · 1
TAB1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L53, 4O91, 5DIY, 5JGA, 5JGD

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein bp kinase gene chr human band chromosome 22 mitogen-activated location function map3k7 binding enzyme mouse tak1 encoded external search

TAB1 relationships Subject–Predicate–Object triples

TTTA extracted 115 structured relationships around TAB1. Examples in this analysis include TAB1 → Aliases → TAB1, 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1 and TAB1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L53, 4O91, 5DIY, 5JGA, 5JGD. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TAB1AliasesTAB1, 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 11.00infobox
TAB1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L53, 4O91, 5DIY, 5JGA, 5JGD1.00infobox
TAB1Band22q13.11.00infobox
TAB1Band15|15 E11.00infobox
TAB1Bgeeparotid gland1.00infobox
TAB1Bgeelateral nuclear group of thalamus1.00infobox
TAB1Bgeeventricular zone1.00infobox
TAB1Bgeeright hemisphere of cerebellum1.00infobox
TAB1Bgeesural nerve1.00infobox
TAB1Bgeeapex of heart1.00infobox
TAB1BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
TAB1Bgeeright frontal lobe1.00infobox
TAB1Bgeesubthalamic nucleus1.00infobox
TAB1Bgeeright ventricle1.00infobox
TAB1Bgeeotic vesicle1.00infobox
TAB1Bgeeneural layer of retina1.00infobox
TAB1Bgeeinternal carotid artery1.00infobox
TAB1Bgeeexternal carotid artery1.00infobox
TAB1Bgeegranulocyte1.00infobox
TAB1Bgeesaccule1.00infobox
TAB1Bgeemuscle of thigh1.00infobox
TAB1Bgeeright kidney1.00infobox
TAB1Bgeelip1.00infobox
TAB1BioGPSMore reference expression data1.00infobox
TAB1Chr.Chromosome 22 (human)1.00infobox
TAB1Chr.Chromosome 15 (mouse)1.00infobox
TAB1DatabasesNCBI: entry; OMA: entry1.00infobox
TAB1End39,437,060 bp1.00infobox
TAB1End80,045,908 bp1.00infobox
TAB1EnsemblENSG000001003241.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TAB1 bring nearby vocabulary together. In this analysis, examples include Map3k7, Search and Tgf-beta. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • enzyme
    • Encoded
    • Mitogen-activated
    • Gene
    • Map
    • Signaling
    • Kinase
    • Tab1
    • Beta
    • Biological
    • End
    • External
    • Mouse
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • External
    • Kinase
    • Mouse
    • Search
    • Tab1
    • Tgf-beta
  • map kinase kinase kinase
    • Signaling
    • Protein
    • Mitogen-activated
    • Gene
    • Mouse
    • Pathway
    • Pathways
    • Search
    • Tgf-beta
    • Various
    • Tab1
    • Biological
  • mitogen-activated protein kinase 14
    • Protein
    • Biological
    • Encoded
    • Enzyme
    • Pathway
    • Pathways
    • Various
    • Kinase
    • Mitogen-activated
    • Gene
    • Binding
    • Function
  • function
    • Binding
    • Beta
    • External
    • Search
    • Tgf-beta
    • Location
    • Map3k7
    • Tak1
    • Protein
    • Chromosome
    • Gene
    • Human
  • map3k7
    • Search
    • Tgf-beta
    • Tab1
    • Location
    • Human
    • Map
    • Signaling
    • Beta
    • Biological
    • End
    • Interact
    • Mapk14
  • TAB1
    • Map3k7
    • Search
    • Tgf-beta
    • Location
    • Human
    • Map
    • Signaling
    • Beta
    • Biological
    • End
    • Interact
    • Mapk14
  • tab1
    • Map3k7
    • Search
    • Tgf-beta
    • Location
    • Human
    • Map
    • Signaling
    • Beta
    • Biological
    • End
    • Interact
    • Mapk14

Connections between topic areas Semantic bridges

For TAB1, one of the stronger structural bridges in this analysis connects TAB1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TAB1Function · splits 15 ⟂ 15
TAB1Interactions · splits 19 ⟂ 11
TAB1Overview · splits 27 ⟂ 3

Map overview Semantic statistics

TAB1

Nodes30
Edges29
Triples115
Avg. degree1.93
Density0.066667
Components1

Source & methodology

TTTA analyzes the structure around TAB1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TAB1 · EN edition · Analysis: TopicsToTalkAbout

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