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Imatinib: History, Community, Culture & Applications

Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral targeted therapy medication used to treat cancer. Imatinib is a small molecule inhibitor targeting multiple tyrosine kinases such as CSF1R, ABL, c-KIT, FLT3, and PDGFR-β. Specifically, it is used for chronic myelogenous leukemia (CML)…

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Imatinib topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Imatinib.

Related topics
160
Source areas
8
Connected nodes
168
Extracted relationships
197
Concept neighborhoods
31
Bridge connections
168

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 40 topics
Pharmacology · 26 topics
Interactions · 22 topics
History · 20 topics
Research · 18 topics
Medical uses · 16 topics
Side effects · 14 topics
Society and culture · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EA01 (WHO)
Bioavailability
98%
CAS Number
152459-95-5 Y 220127-57-1 (mesilate)
ChEBI
CHEBI:45783 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Interactions

Pharmacology

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Imatinib connects Entity context

The extracted context around Imatinib shows recurring relationship patterns in the source. For example, Imatinib → After, Anthony, Biological Studies, Brian Druker, British, California, Carlo Gambacorti-Passerini, Center, Charles Sawyers, Ciba-Geigy, CML, Elisabeth Buchdunger, Hammersmith Hospital, Hunter, Italy, John Goldman, Jürg Zimmermann, La Jolla, London, Memorial Sloan Kettering Cancer Another extracted example is Imatinib → Abelson, ABL, As, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, FIP1L1-PDGFRalpha, It, Kit, Metabolism, Most, N-demethylated, P450, PDGFR, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Imatinib

Top relations

related to history · 34
Imatinib → After, Anthony, Biological Studies, Brian Druker, British, California, Carlo Gambacorti-Passerini, Center, Charles Sawyers, Ciba-Geigy, CML, Elisabeth Buchdunger, Hammersmith Hospital, Hunter, Italy, John Goldman, Jürg Zimmermann, La Jolla, London, Memorial Sloan Kettering Cancer
related to Pharmacokinetics · 17
Imatinib → Abelson, ABL, As, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, FIP1L1-PDGFRalpha, It, Kit, Metabolism, Most, N-demethylated, P450, PDGFR, The
related to Other · 13
Imatinib → ALL, CHIC2, D816V, FIP1L1-PDGFRα, For, Gleevec, January, KIT, On, Ph, Philadelphia, The FDA, There
related to Interactions · 12
Imatinib → An, As, Conversely, CYP2C9, CYP2D6, CYP3A4, Inactivated, Its, Likewise, Since, St John's Wort, The
related to Economics · 11
Imatinib → Blood, Brian Druker, Carlo Gambacorti-Passerini, Druker, In, John Goldman, Novartis, Other, Signatories, They, United States
related to Medical uses · 11
Imatinib → ALL, ASM, CCyR, CML, DFSP, FDA, GISTs, In, It, MDS/MPD, MMR
related to Chronic myelogenous leukemia · 9
Imatinib → By, CML, Drug Administration, Due, FDA, Food, Philadelphia, Starting, The
related to Cardiotoxicity · 7
Imatinib → ABL, ABL1, Cardiotoxic, Clinical, In, Patient, Studies
related to Gastrointestinal stromal tumors · 7
Imatinib → February, GIST, KIT-positive, KIT-positive GISTs, On, The, The FDA
related to Research · 7
Imatinib → D816V, Experience, However, It, KIT, One, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

novartis patent drug tyrosine gleevec treatment may use kinase also c-kit effects patients application bcr-abl mesylate growth used cyp3a4 chronic

Imatinib relationships Subject–Predicate–Object triples

TTTA extracted 197 structured relationships around Imatinib. Examples in this analysis include Imatinib → 3D model (JSmol) → Interactive image and Imatinib → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Imatinib3D model (JSmol)Interactive image1.00infobox
ImatinibAHFS/Drugs.comMonograph1.00infobox
ImatinibATC codeL01EA01 (WHO)1.00infobox
ImatinibBioavailability98%1.00infobox
ImatinibCAS Number152459-95-5 Y 220127-57-1 (mesilate)1.00infobox
ImatinibChEBICHEBI:45783 Y1.00infobox
ImatinibChEMBLChEMBL941 Y1.00infobox
ImatinibChemSpider5101 Y1.00infobox
ImatinibCompTox Dashboard (EPA)DTXSID30371251.00infobox
ImatinibDrug classTyrosine kinase inhibitor1.00infobox
ImatinibDrugBankDB00619 Y1.00infobox
ImatinibECHA InfoCard100.122.7391.00infobox
ImatinibElimination half-life18 h (imatinib) 40 h (active metabolite)1.00infobox
ImatinibExcretionFecal (68%) and kidney (13%)1.00infobox
ImatinibFormulaC29H31N7O1.00infobox
ImatinibIUPHAR/BPS56871.00infobox
ImatinibKEGGD08066 Y1.00infobox
ImatinibLegal statusAU: S4 (Prescription only)1.00infobox
ImatinibLegal statusCA: ℞-only1.00infobox
ImatinibLegal statusUK: POM (Prescription only)1.00infobox
ImatinibLegal statusUS: ℞-only1.00infobox
ImatinibLegal statusEU: Rx-only1.00infobox
ImatinibLicense dataUS DailyMed: Imatinib1.00infobox
ImatinibMedlinePlusa6060181.00infobox
ImatinibMetabolismLiver (mainly CYP3A4-mediated)1.00infobox
ImatinibMolar mass493.615 g·mol−11.00infobox
ImatinibOther namesSTI-5711.00infobox
ImatinibPDB ligandSTI (PDBe, RCSB PDB)1.00infobox
ImatinibPregnancy categoryAU: D1.00infobox
ImatinibPronunciationih-MAT-ih-nib1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Imatinib bring nearby vocabulary together. In this analysis, examples include Treatment, Tyrosine and Mesylate. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Imatinib
    • Treatment
    • Tyrosine
    • Mesylate
    • Drug
    • Kinase
    • Effective
    • C-kit
    • Patent
    • Novartis
    • Inhibitor
    • Cml
    • Drugs
  • imatinib
    • Treatment
    • Tyrosine
    • Mesylate
    • Drug
    • Kinase
    • Effective
    • C-kit
    • Patent
    • Novartis
    • Inhibitor
    • Cml
    • Drugs
  • chronic myelogenous leukemia
    • Leukemia
    • Cml
    • Used
    • Mastocytosis
    • Protein
    • Effective
    • Drugs
    • Growth
    • Kinase
    • Treatment
    • Liver
    • Side
  • chronic eosinophilic leukemia
    • Leukemia
    • Cml
    • Used
    • Mastocytosis
    • Protein
    • Effective
    • Drugs
    • Growth
    • Kinase
    • Treatment
    • Liver
    • Side
  • drug itself
    • Gleevec
    • Liver
    • Fda
    • Cyp3a4
    • Imatinib
    • Effects
    • Application
    • Novartis
    • Side
    • Patent
    • Protein
    • Activity
  • food and drug administration
    • Gleevec
    • Liver
    • Fda
    • Cyp3a4
    • Imatinib
    • Effects
    • Application
    • Novartis
    • Side
    • Patent
    • Protein
    • Activity
  • rational drug design
    • Gleevec
    • Liver
    • Fda
    • Cyp3a4
    • Imatinib
    • Effects
    • Application
    • Novartis
    • Side
    • Patent
    • Protein
    • Activity
  • acute lymphocytic leukemia
    • Cml
    • Mastocytosis
    • Protein
    • Effective
    • Drugs
    • Used
    • Growth
    • Kinase
    • Treatment
    • Liver
    • Side
    • Active

Connections between topic areas Semantic bridges

For Imatinib, one of the stronger structural bridges in this analysis connects Imatinib with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Imatinib — Overview · splits 128 ⟂ 41
Imatinib — Pharmacology · splits 142 ⟂ 27
Imatinib — Interactions · splits 146 ⟂ 23
Imatinib — History · splits 148 ⟂ 21
Imatinib — Research · splits 150 ⟂ 19
Imatinib — Medical uses · splits 152 ⟂ 17
Imatinib — Side effects · splits 154 ⟂ 15
Imatinib — Society and culture · splits 164 ⟂ 5

Map overview Semantic statistics

Imatinib

Nodes169
Edges168
Triples197
Avg. degree1.99
Density0.011834
Components1

Source & methodology

TTTA analyzes the structure around Imatinib to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Imatinib · EN edition · Analysis: TopicsToTalkAbout

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