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Plerixafor

Plerixafor, sold under the brand name Mozobil, is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and transplanted back to the patient. The drug was developed by AnorMED, which was subsequently bought by Genzyme.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L03AX16 (WHO)
CAS Number
110078-46-1 Y · as salt: 155148-31-5 Y
ChEBI
CHEBI:125354
ChEMBL
ChEMBL18442 Y

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Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Plerixafor

Nodes77
Edges76
Triples96
Avg. degree1.97
Density0.025974
Components1

How this topic connects Entity context

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Plerixafor

Top relations

related to Society and culture · 15
Plerixafor → Canada, Committee, December, Drug Administration, European Union, FDA, Food, Health Canada, Human Use, In, It, May, Medicinal Products, The, United States
related to Mechanism of action · 9
Plerixafor → Additionally, CD20, CXCR4, CXCR4/SDF1, CXCR7, In, SDF-1, The, The CXCR4
has effect · 8
Plerixafor → Allergies, G-CSF, Mobilisation, Most, Nausea, Other, The, The European Medicines Agency
related to Medical uses · 7
Plerixafor → Combination, CXCL2, G-CSF, MGTA-145, Peripheral, Phase, The
related to Pharmacokinetics · 6
Plerixafor → Following, P-glycoproteins, P450, Plasma, The, Up
Legal status · 4
Plerixafor → CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only
related to Pregnancy and lactation · 4
Plerixafor → Breast, Fertile, It, Studies
related to Use in stem cell research · 4
Plerixafor → Imperial College, In, Researchers, VEGF
related to Anti-cancer properties · 3
Plerixafor → In, It, SDF-1 CXCR4
related to Synthesis · 3
Plerixafor → After, The, Three

Important terminology Word statistics

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Important terminology

cells stem drug cxcr4 patients studies hematopoietic use blood cell approved found cancer zinc effects interactions hours model name mozobil

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Plerixafor3D model (JSmol)Interactive image1.00infobox
PlerixaforAHFS/Drugs.comMonograph1.00infobox
PlerixaforATC codeL03AX16 (WHO)1.00infobox
PlerixaforCAS Number110078-46-1 Y1.00infobox
PlerixaforCAS Numberas salt: 155148-31-5 Y1.00infobox
PlerixaforChEBICHEBI:1253541.00infobox
PlerixaforChEMBLChEMBL18442 Y1.00infobox
PlerixaforChemSpider58531 Y1.00infobox
PlerixaforCompTox Dashboard (EPA)DTXSID708695201.00infobox
PlerixaforDrugBankDB06809 Y1.00infobox
PlerixaforElimination half-life3–5 hours1.00infobox
PlerixaforExcretionKidney1.00infobox
PlerixaforFormulaC28H54N81.00infobox
PlerixaforIUPHAR/BPS8441.00infobox
PlerixaforKEGGD08971 Y1.00infobox
PlerixaforLegal statusCA: ℞-only1.00infobox
PlerixaforLegal statusUS: ℞-only1.00infobox
PlerixaforLegal statusEU: Rx-only1.00infobox
PlerixaforLegal statusIn general: ℞ (Prescription only)1.00infobox
PlerixaforLicense dataUS DailyMed: Plerixafor1.00infobox
PlerixaforMedlinePlusa6090181.00infobox
PlerixaforMetabolismNone1.00infobox
PlerixaforMolar mass502.796 g·mol−11.00infobox
PlerixaforOther namesJM 3100, AMD31001.00infobox
PlerixaforPregnancy categoryAU: D1.00infobox
PlerixaforProtein bindingUp to 58%1.00infobox
PlerixaforPubChem CID650151.00infobox
PlerixaforRoutes of administrationSubcutaneous1.00infobox
PlerixaforTrade namesMozobil1.00infobox
PlerixaforUNIIS915P5499N1.00infobox

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