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Plerixafor: History, Community, Culture & Applications

Plerixafor, sold under the brand name Mozobil, is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and transplanted back to the patient. The drug was developed by AnorMED, which was subsequently bought by Genzyme.

Language: English [EN]
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Plerixafor topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Plerixafor.

Related topics
67
Source areas
9
Connected nodes
76
Extracted relationships
96
Concept neighborhoods
18
Bridge connections
76

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 21 topics
Chemistry · 14 topics
Medical uses · 7 topics
Research · 7 topics
Adverse effects · 5 topics
Overview · 4 topics
Society and culture · 4 topics
History · 3 topics
Contraindications · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L03AX16 (WHO)
CAS Number
110078-46-1 Y · as salt: 155148-31-5 Y
ChEBI
CHEBI:125354
ChEMBL
ChEMBL18442 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Plerixafor connects Entity context

The extracted context around Plerixafor shows recurring relationship patterns in the source. For example, Plerixafor → Canada, Committee, December, Drug Administration, European Union, FDA, Food, Health Canada, Human Use, In, It, May, Medicinal Products, The, United States Another extracted example is Plerixafor → Additionally, CD20, CXCR4, CXCR4/SDF1, CXCR7, In, SDF-1, The, The CXCR4. Use these groups to spot repeated connection types before inspecting the individual relationships.

Plerixafor

Top relations

related to Society and culture · 15
Plerixafor → Canada, Committee, December, Drug Administration, European Union, FDA, Food, Health Canada, Human Use, In, It, May, Medicinal Products, The, United States
related to Mechanism of action · 9
Plerixafor → Additionally, CD20, CXCR4, CXCR4/SDF1, CXCR7, In, SDF-1, The, The CXCR4
has effect · 8
Plerixafor → Allergies, G-CSF, Mobilisation, Most, Nausea, Other, The, The European Medicines Agency
related to Medical uses · 7
Plerixafor → Combination, CXCL2, G-CSF, MGTA-145, Peripheral, Phase, The
related to Pharmacokinetics · 6
Plerixafor → Following, P-glycoproteins, P450, Plasma, The, Up
Legal status · 4
Plerixafor → CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only
related to Pregnancy and lactation · 4
Plerixafor → Breast, Fertile, It, Studies
related to Use in stem cell research · 4
Plerixafor → Imperial College, In, Researchers, VEGF
related to Anti-cancer properties · 3
Plerixafor → In, It, SDF-1 CXCR4
related to Synthesis · 3
Plerixafor → After, The, Three

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells stem drug cxcr4 patients studies hematopoietic use blood cell approved found cancer zinc effects interactions hours model name mozobil

Plerixafor relationships Subject–Predicate–Object triples

TTTA extracted 96 structured relationships around Plerixafor. Examples in this analysis include Plerixafor → 3D model (JSmol) → Interactive image and Plerixafor → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Plerixafor3D model (JSmol)Interactive image1.00infobox
PlerixaforAHFS/Drugs.comMonograph1.00infobox
PlerixaforATC codeL03AX16 (WHO)1.00infobox
PlerixaforCAS Number110078-46-1 Y1.00infobox
PlerixaforCAS Numberas salt: 155148-31-5 Y1.00infobox
PlerixaforChEBICHEBI:1253541.00infobox
PlerixaforChEMBLChEMBL18442 Y1.00infobox
PlerixaforChemSpider58531 Y1.00infobox
PlerixaforCompTox Dashboard (EPA)DTXSID708695201.00infobox
PlerixaforDrugBankDB06809 Y1.00infobox
PlerixaforElimination half-life3–5 hours1.00infobox
PlerixaforExcretionKidney1.00infobox
PlerixaforFormulaC28H54N81.00infobox
PlerixaforIUPHAR/BPS8441.00infobox
PlerixaforKEGGD08971 Y1.00infobox
PlerixaforLegal statusCA: ℞-only1.00infobox
PlerixaforLegal statusUS: ℞-only1.00infobox
PlerixaforLegal statusEU: Rx-only1.00infobox
PlerixaforLegal statusIn general: ℞ (Prescription only)1.00infobox
PlerixaforLicense dataUS DailyMed: Plerixafor1.00infobox
PlerixaforMedlinePlusa6090181.00infobox
PlerixaforMetabolismNone1.00infobox
PlerixaforMolar mass502.796 g·mol−11.00infobox
PlerixaforOther namesJM 3100, AMD31001.00infobox
PlerixaforPregnancy categoryAU: D1.00infobox
PlerixaforProtein bindingUp to 58%1.00infobox
PlerixaforPubChem CID650151.00infobox
PlerixaforRoutes of administrationSubcutaneous1.00infobox
PlerixaforTrade namesMozobil1.00infobox
PlerixaforUNIIS915P5499N1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Plerixafor bring nearby vocabulary together. In this analysis, examples include Cells, Stem and Cxcr4. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Plerixafor
    • Cells
    • Stem
    • Cxcr4
    • Combination
    • Interactions
    • Mobilization
    • Peripheral
    • Blood
    • Patients
    • Bloodstream
    • Subcutaneous
    • Bone
  • plerixafor
    • Cells
    • Stem
    • Cxcr4
    • Combination
    • Interactions
    • Mobilization
    • Peripheral
    • Blood
    • Patients
    • Bloodstream
    • Subcutaneous
    • Bone
  • hematopoietic stem cells
    • Stem
    • Mobilization
    • Plerixafor
    • Blood
    • Bloodstream
    • Mozobil
    • Name
    • Cells
    • Hematopoietic
    • Bone
    • Cell
    • Marrow
  • peripheral blood stem cell mobilization
    • Peripheral
    • Mobilization
    • Stem
    • Cells
    • Hematopoietic
    • Pregnancy
    • Chemistry
    • Mozobil
    • Name
    • Subcutaneous
    • Bone
    • Combination
  • peripheral blood stem cells
    • Peripheral
    • Stem
    • Mobilization
    • Plerixafor
    • Blood
    • Cells
    • Hematopoietic
    • Pregnancy
    • Subcutaneous
    • Bone
    • Combination
    • Marrow
  • committee for medicinal products for human use
    • Approved
    • Pregnancy
    • Adverse
    • Chemistry
    • Drug
    • Mozobil
    • Name
    • Subcutaneous
    • Cell
    • Effects
    • European
    • G-csf
  • mesenchymal stem cells
    • Stem
    • Plerixafor
    • Blood
    • Hematopoietic
    • Mobilization
    • Peripheral
    • Bone
    • Combination
    • Marrow
    • Patients
    • Bloodstream
    • Mozobil
  • endothelial progenitor cells
    • Stem
    • Plerixafor
    • Blood
    • Hematopoietic
    • Mobilization
    • Peripheral
    • Patients
    • Bloodstream
    • Mozobil
    • Name
    • Subcutaneous
    • Bone

Connections between topic areas Semantic bridges

For Plerixafor, one of the stronger structural bridges in this analysis connects Plerixafor with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Plerixafor — Pharmacology · splits 55 ⟂ 22
Plerixafor — Chemistry · splits 62 ⟂ 15
Plerixafor — Medical uses · splits 69 ⟂ 8
Plerixafor — Research · splits 69 ⟂ 8
Plerixafor — Adverse effects · splits 71 ⟂ 6
Plerixafor — Overview · splits 72 ⟂ 5
Plerixafor — Society and culture · splits 72 ⟂ 5
Plerixafor — History · splits 73 ⟂ 4
Plerixafor — Contraindications · splits 74 ⟂ 3

Map overview Semantic statistics

Plerixafor

Nodes77
Edges76
Triples96
Avg. degree1.97
Density0.025974
Components1

Source & methodology

TTTA analyzes the structure around Plerixafor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Plerixafor · EN edition · Analysis: TopicsToTalkAbout

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