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Stromal cell-derived factor 1: Function, Structure & Clinical significance

The stromal cell-derived factor 1 (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types. Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the chemokine family, members of…

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Stromal cell-derived factor 1 topic overview

The analysis highlights Function, Structure and Clinical significance as prominent areas in the source structure around Stromal cell-derived factor 1.

Related topics
46
Source areas
4
Connected nodes
50
Extracted relationships
137
Concept neighborhoods
17
Bridge connections
50

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 17 topics
Overview · 14 topics
Structure · 8 topics
Clinical significance · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 12
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A15, 1QG7, 1SDF, 1VMC, 2J7Z, 2K01, 2K03, 2K04, 2K05, 2KEC, 2KED, 2KEE, 2KOL, 2NWG, 2SDF, 3GV3, 3HP3, 4LMQ,…
Band
10q11.21 · 6 54.81 cM|6 F1
Bgee
synovial joint · pericardium · lactiferous duct · skin of hip · trabecular bone
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Stromal cell-derived factor 1 connects Entity context

The extracted context around Stromal cell-derived factor 1 shows recurring relationship patterns in the source. For example, Stromal cell-derived factor 1 → adult locomotory behavior, animal organ regeneration, antimicrobial humoral immune response mediated by antimicrobial peptide, axon guidance, blood circulation, brain development, cell adhesion, cell chemotaxis, cellular calcium ion homeostasis, cellular response to chemokine, chemoattractant activity, chemokine (C-X-C motif) ligand 12 signaling pathway, chemokine activity, chemokine receptor binding, chemokine-mediated signaling pathway, chemotaxis, collagen-containing extracellular matrix, CXCR chemokine receptor binding, cytokine activity, cytoplasm Another extracted example is Stromal cell-derived factor 1 → ankle, ankle joint, external carotid artery, gallbladder, Gonadal ridge, internal carotid artery, lactiferous duct, parietal pleura, pericardium, skin of hip, spleen, stroma of bone marrow, superficial temporal artery, synovial joint, synovial membrane, thymus, tibiofemoral joint, trabecular bone, vas deferens, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

Stromal cell-derived factor 1

Top relations

Gene ontology · 67
Stromal cell-derived factor 1 → adult locomotory behavior, animal organ regeneration, antimicrobial humoral immune response mediated by antimicrobial peptide, axon guidance, blood circulation, brain development, cell adhesion, cell chemotaxis, cellular calcium ion homeostasis, cellular response to chemokine, chemoattractant activity, chemokine (C-X-C motif) ligand 12 signaling pathway, chemokine activity, chemokine receptor binding, chemokine-mediated signaling pathway, chemotaxis, collagen-containing extracellular matrix, CXCR chemokine receptor binding, cytokine activity, cytoplasm
Bgee · 20
Stromal cell-derived factor 1 → ankle, ankle joint, external carotid artery, gallbladder, Gonadal ridge, internal carotid artery, lactiferous duct, parietal pleura, pericardium, skin of hip, spleen, stroma of bone marrow, superficial temporal artery, synovial joint, synovial membrane, thymus, tibiofemoral joint, trabecular bone, vas deferens, vena cava
RNA expression pattern · 20
Stromal cell-derived factor 1 → ankle, ankle joint, external carotid artery, gallbladder, Gonadal ridge, internal carotid artery, lactiferous duct, parietal pleura, pericardium, skin of hip, spleen, stroma of bone marrow, superficial temporal artery, synovial joint, synovial membrane, thymus, tibiofemoral joint, trabecular bone, vas deferens, vena cava
Band · 2
Stromal cell-derived factor 1 → 10q11.21, 6 54.81 cM|6 F1
Chr. · 2
Stromal cell-derived factor 1 → Chromosome 10 (human), Chromosome 6 (mouse)
End · 2
Stromal cell-derived factor 1 → 117,158,328 bp, 44,386,493 bp
Aliases · 1
Stromal cell-derived factor 1 → CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 12
Available structures · 1
Stromal cell-derived factor 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A15, 1QG7, 1SDF, 1VMC, 2J7Z, 2K01, 2K03, 2K04, 2K05, 2KEC, 2KED, 2KEE, 2KOL, 2NWG, 2SDF, 3GV3, 3HP3, 4LMQ,…
BioGPS · 1
Stromal cell-derived factor 1 → More reference expression data
Databases · 1
Stromal cell-derived factor 1 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cxcl12 gene chemokine receptor cxcr4 chromosome 10 bp band also brain chr protein human chemokines alzheimer's bone cell cells motif

Stromal cell-derived factor 1 relationships Subject–Predicate–Object triples

TTTA extracted 137 structured relationships around Stromal cell-derived factor 1. Examples in this analysis include Stromal cell-derived factor 1 → Aliases → CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 12 and Stromal cell-derived factor 1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A15, 1QG7, 1SDF, 1VMC, 2J7Z, 2K01, 2K03, 2K04, 2K05, 2KEC, 2KED, 2KEE, 2KOL, 2NWG, 2SDF, 3GV3, 3HP3, 4LMQ,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Stromal cell-derived factor 1AliasesCXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 121.00infobox
Stromal cell-derived factor 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A15, 1QG7, 1SDF, 1VMC, 2J7Z, 2K01, 2K03, 2K04, 2K05, 2KEC, 2KED, 2KEE, 2KOL, 2NWG, 2SDF, 3GV3, 3HP3, 4LMQ,…1.00infobox
Stromal cell-derived factor 1Band10q11.211.00infobox
Stromal cell-derived factor 1Band6 54.81 cM|6 F11.00infobox
Stromal cell-derived factor 1Bgeesynovial joint1.00infobox
Stromal cell-derived factor 1Bgeepericardium1.00infobox
Stromal cell-derived factor 1Bgeelactiferous duct1.00infobox
Stromal cell-derived factor 1Bgeeskin of hip1.00infobox
Stromal cell-derived factor 1Bgeetrabecular bone1.00infobox
Stromal cell-derived factor 1Bgeeparietal pleura1.00infobox
Stromal cell-derived factor 1Bgeesynovial membrane1.00infobox
Stromal cell-derived factor 1Bgeesuperficial temporal artery1.00infobox
Stromal cell-derived factor 1Bgeegallbladder1.00infobox
Stromal cell-derived factor 1Bgeevena cava1.00infobox
Stromal cell-derived factor 1Bgeestroma of bone marrow1.00infobox
Stromal cell-derived factor 1Bgeetibiofemoral joint1.00infobox
Stromal cell-derived factor 1BgeeGonadal ridge1.00infobox
Stromal cell-derived factor 1Bgeevas deferens1.00infobox
Stromal cell-derived factor 1Bgeeinternal carotid artery1.00infobox
Stromal cell-derived factor 1Bgeespleen1.00infobox
Stromal cell-derived factor 1Bgeeankle1.00infobox
Stromal cell-derived factor 1Bgeeankle joint1.00infobox
Stromal cell-derived factor 1Bgeeexternal carotid artery1.00infobox
Stromal cell-derived factor 1Bgeethymus1.00infobox
Stromal cell-derived factor 1BioGPSMore reference expression data1.00infobox
Stromal cell-derived factor 1Chr.Chromosome 10 (human)1.00infobox
Stromal cell-derived factor 1Chr.Chromosome 6 (mouse)1.00infobox
Stromal cell-derived factor 1DatabasesNCBI: entry; OMA: entry1.00infobox
Stromal cell-derived factor 1End44,386,493 bp1.00infobox
Stromal cell-derived factor 1End117,158,328 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Stromal cell-derived factor 1 bring nearby vocabulary together. In this analysis, examples include Motif, Chromosome and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Stromal cell-derived factor 1
    • Motif
    • Chromosome
    • Expression
    • Protein
    • Chemokine
    • Receptor
    • Gene
    • Mouse
    • Associated
    • Band
    • Damage
    • Development
  • stromal cell-derived factor 1
    • Motif
    • Chromosome
    • Expression
    • Protein
    • Chemokine
    • Receptor
    • Gene
    • Mouse
    • Associated
    • Band
    • Damage
    • Development
  • chemokine
    • Protein
    • Motif
    • Multiple
    • Chromosome
    • Factor
    • Gene
    • Damage
    • Development
    • Human
    • Immune
    • Blood
    • Bp
  • gene
    • Disease
    • Human
    • Motif
    • Bp
    • Chr
    • Protein
    • Mouse
    • Band
    • Increased
    • Associated
    • Cns
    • Damage
  • chromosome 10
    • Human
    • Bp
    • Chr
    • Band
    • Motif
    • Gene
    • Protein
    • Factor
    • Mouse
    • Disease
    • Cns
    • Damage
  • receptor
    • Factor
    • Mouse
    • Increased
    • Motif
    • Cxcl12
    • Blood
    • Expression
    • Marrow
    • Also
    • Bone
    • Cxcr4
    • C-x-c
  • bone marrow
    • Marrow
    • Cells
    • Expressed
    • Blood
    • Mouse
    • Migration
    • Brain
    • Cxcr4
    • Receptor
    • Cxcl12
    • C-x-c
    • Damage
  • cxcr7 receptor
    • Factor
    • Mouse
    • Increased
    • Motif
    • Cxcl12
    • Blood
    • Expression
    • Marrow
    • Also
    • Bone
    • Cxcr4
    • C-x-c

Connections between topic areas Semantic bridges

For Stromal cell-derived factor 1, one of the stronger structural bridges in this analysis connects Stromal cell-derived factor 1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Stromal cell-derived factor 1Function · splits 33 ⟂ 18
Stromal cell-derived factor 1Overview · splits 36 ⟂ 15
Stromal cell-derived factor 1Structure · splits 42 ⟂ 9
Stromal cell-derived factor 1Clinical significance · splits 43 ⟂ 8

Map overview Semantic statistics

Stromal cell-derived factor 1

Nodes51
Edges50
Triples137
Avg. degree1.96
Density0.039216
Components1

Source & methodology

TTTA analyzes the structure around Stromal cell-derived factor 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Stromal cell-derived factor 1 · EN edition · Analysis: TopicsToTalkAbout

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