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MAP2K7

Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene. This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different isoforms with three possible N-termini (α, β, and γ isoforms) and two…

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2.7.12.2
↗
Aliases
MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 7
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M
Band
19p13.2 · 8|8 A1.1
Bgee
buccal mucosa cell · tendon of biceps brachii · gastrocnemius muscle · right hemisphere of cerebellum · Skeletal muscle tissue of rectus abdominis
BioGPS
n/a

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MAP2K7

Nodes57
Edges56
Triples155
Avg. degree1.96
Density0.035088
Components1

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MAP2K7

Top relations

Gene ontology · 39
MAP2K7 → activation of protein kinase activity, apoptotic process, ATP binding, cytoplasm, cytosol, enzyme binding, Fc-epsilon receptor signaling pathway, JNK cascade, JUN kinase kinase activity, kinase activity, magnesium ion binding, MAP kinase kinase activity, metal ion binding, nucleotide binding, nucleus, peptidyl-tyrosine phosphorylation, phosphorylation, positive regulation of ERK1 and ERK2 cascade, positive regulation of telomerase activity, positive regulation of telomere capping
related to Signaling and regulation · 23
MAP2K7 → Although MKK7, As, C-terminus, DVD, In, JNK, JNKs, Jun N-terminal, MKK4, MKK7, MKK7s, MKKKs, MKKs, Once, Overall, Phosphorylated, S-K-A-K-T, SAP/JNK, T-P-Y, The
Bgee · 20
MAP2K7 → arcuate nucleus, body of tongue, body of uterus, buccal mucosa cell, cardia, dorsomedial hypothalamic nucleus, external carotid artery, gastrocnemius muscle, Gonadal ridge, habenula, internal carotid artery, lateral geniculate nucleus, lateral hypothalamus, median eminence, muscle of thigh, nipple, paraventricular nucleus of hypothalamus, right hemisphere of cerebellum, Skeletal muscle tissue of rectus abdominis, tendon of biceps brachii
RNA expression pattern · 20
MAP2K7 → arcuate nucleus, body of tongue, body of uterus, buccal mucosa cell, cardia, dorsomedial hypothalamic nucleus, external carotid artery, gastrocnemius muscle, Gonadal ridge, habenula, internal carotid artery, lateral geniculate nucleus, lateral hypothalamus, median eminence, muscle of thigh, nipple, paraventricular nucleus of hypothalamus, right hemisphere of cerebellum, Skeletal muscle tissue of rectus abdominis, tendon of biceps brachii
related to Nomenclature · 10
MAP2K7 → ERK, JNK, JNKK2, Jun N-terminal, MEK7, MKK7JNK-activated, SAPK, SAPKK4, SEK2, Stress-activated
related to Biological relevance · 9
MAP2K7 → Conditional, Experiments, Genetic, In, Metastase Suppressor Gene, MKK4, MKK7, MSG, Neuron-specific
Band · 2
MAP2K7 → 19p13.2, 8|8 A1.1
Chr. · 2
MAP2K7 → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
MAP2K7 → 4,297,897 bp, 7,914,478 bp
2.7.12.2 · 1
MAP2K7 → ↗

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Important terminology

mkk7 kinase jnk protein isoforms phosphorylation d-motifs also mkk4 bp threonine gene dvd region kinases chr human band signaling activated

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAP2K72.7.12.2↗1.00infobox
MAP2K7AliasesMAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 71.00infobox
MAP2K7Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M1.00infobox
MAP2K7Band19p13.21.00infobox
MAP2K7Band8|8 A1.11.00infobox
MAP2K7Bgeebuccal mucosa cell1.00infobox
MAP2K7Bgeetendon of biceps brachii1.00infobox
MAP2K7Bgeegastrocnemius muscle1.00infobox
MAP2K7Bgeeright hemisphere of cerebellum1.00infobox
MAP2K7BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
MAP2K7Bgeenipple1.00infobox
MAP2K7Bgeemuscle of thigh1.00infobox
MAP2K7Bgeecardia1.00infobox
MAP2K7Bgeebody of tongue1.00infobox
MAP2K7Bgeebody of uterus1.00infobox
MAP2K7Bgeeexternal carotid artery1.00infobox
MAP2K7Bgeeinternal carotid artery1.00infobox
MAP2K7Bgeemedian eminence1.00infobox
MAP2K7BgeeGonadal ridge1.00infobox
MAP2K7Bgeehabenula1.00infobox
MAP2K7Bgeearcuate nucleus1.00infobox
MAP2K7Bgeelateral geniculate nucleus1.00infobox
MAP2K7Bgeeparaventricular nucleus of hypothalamus1.00infobox
MAP2K7Bgeedorsomedial hypothalamic nucleus1.00infobox
MAP2K7Bgeelateral hypothalamus1.00infobox
MAP2K7BioGPSn/a1.00infobox
MAP2K7Chr.Chromosome 19 (human)1.00infobox
MAP2K7Chr.Chromosome 8 (mouse)1.00infobox
MAP2K7DatabasesNCBI: entry; OMA: entry1.00infobox
MAP2K7End7,914,478 bp1.00infobox

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