Tropomyosin receptor kinase A

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2.7.10.1: ↗
Aliases: NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS
Band: 1q23.1 · 3 F1|3 38.62 cM
Bgee: spinal ganglia · apex of heart · testicle · gonad · right auricle of heart
BioGPS: More reference expression data

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Overview

Protein
Gene
Neurotrophic tyrosine kinase receptor (NTKR) family Trk receptor
Neurotrophin
Autophosphorylation
MAPK pathway MAPK/ERK pathway
Congenital insensitivity to pain with anhidrosis
Cancers Cancer

Function

Catalytic receptor
Nerve growth factor
Neuronal Neuron
Differentiation Cellular differentiation
Nociceptor response Nociceptor
Programmed cell death Apoptosis
Endocytosis
PI3K/Akt pathway PI3K/AKT/mTOR pathway

Family members

Role in disease

Regulation

Interactions

Interact Protein-protein interaction
Abl gene
FRS2
Grb2
MATK Megakaryocyte-associated tyrosine kinase
NGFB Nerve growth factor
PLCG1
RICS RICS (gene)
SQSTM1 Sequestosome 1
SH2B1
SH2B2
SHC1

Ligands

Amitriptyline
Gambogic acid
Gambogic amide Gambogic amide?action=edit&redlink=1
ACD856
Ponazuril
Positive allosteric modulators Positive allosteric modulator
E2511
Selective Binding selectivity

Role in cancer

Trk inhibitors Trk inhibitor
Entrectinib
Tyrosine kinase inhibitor
TrkB Tropomyosin receptor kinase B
TrkC Tropomyosin receptor kinase C
Larotrectinib

Advanced semantic analysis

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Map overview Semantic statistics

Nodes69

Edges68

Triples161

Avg. degree1.97

Density0.028986

Components1

How this topic connects Entity context

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Tropomyosin receptor kinase A

Top relations

Gene ontology · 96

Tropomyosin receptor kinase A → ageing, ATP binding, axon, axon guidance, axonogenesis involved in innervation, B cell differentiation, behavioral response to formalin induced pain, cell differentiation, cell surface, cellular response to amyloid-beta, cellular response to growth factor stimulus, cellular response to nerve growth factor stimulus, cellular response to nicotine, circadian rhythm, cytoplasm, cytoplasmic vesicle, dendrite, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, early endosome

Bgee · 19

Tropomyosin receptor kinase A → apex of heart, body of uterus, embryo, ganglion of vagus nerve, glossopharyngeal ganglion, gonad, left uterine tube, left ventricle, lumbar spinal ganglion, muscle layer of sigmoid colon, neural tube, pons, right auricle of heart, spinal ganglia, superior cervical ganglion, superior frontal gyrus, superior ganglion of vagus nerve, testicle, trigeminal ganglion

RNA expression pattern · 19

Band · 2

Tropomyosin receptor kinase A → 1q23.1, 3 F1|3 38.62 cM

Chr. · 2

Tropomyosin receptor kinase A → Chromosome 1 (human), Chromosome 3 (mouse)

End · 2

Tropomyosin receptor kinase A → 156,881,850 bp, 87,702,469 bp

2.7.10.1 · 1

Tropomyosin receptor kinase A → ↗

Aliases · 1

Tropomyosin receptor kinase A → NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1

Available structures · 1

Tropomyosin receptor kinase A → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS

BioGPS · 1

Tropomyosin receptor kinase A → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

trka gene receptor trk kinase ngf ntrk1 growth trkb human factor tyrosine differentiation bp role nerve cancer trkc neurotrophin binding

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Tropomyosin receptor kinase A	2.7.10.1	↗	1.00	infobox
Tropomyosin receptor kinase A	Aliases	NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1	1.00	infobox
Tropomyosin receptor kinase A	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS	1.00	infobox
Tropomyosin receptor kinase A	Band	1q23.1	1.00	infobox
Tropomyosin receptor kinase A	Band	3 F1\|3 38.62 cM	1.00	infobox
Tropomyosin receptor kinase A	Bgee	spinal ganglia	1.00	infobox
Tropomyosin receptor kinase A	Bgee	apex of heart	1.00	infobox
Tropomyosin receptor kinase A	Bgee	testicle	1.00	infobox
Tropomyosin receptor kinase A	Bgee	gonad	1.00	infobox
Tropomyosin receptor kinase A	Bgee	right auricle of heart	1.00	infobox
Tropomyosin receptor kinase A	Bgee	left uterine tube	1.00	infobox
Tropomyosin receptor kinase A	Bgee	pons	1.00	infobox
Tropomyosin receptor kinase A	Bgee	muscle layer of sigmoid colon	1.00	infobox
Tropomyosin receptor kinase A	Bgee	left ventricle	1.00	infobox
Tropomyosin receptor kinase A	Bgee	body of uterus	1.00	infobox
Tropomyosin receptor kinase A	Bgee	lumbar spinal ganglion	1.00	infobox
Tropomyosin receptor kinase A	Bgee	superior cervical ganglion	1.00	infobox
Tropomyosin receptor kinase A	Bgee	neural tube	1.00	infobox
Tropomyosin receptor kinase A	Bgee	trigeminal ganglion	1.00	infobox
Tropomyosin receptor kinase A	Bgee	glossopharyngeal ganglion	1.00	infobox
Tropomyosin receptor kinase A	Bgee	embryo	1.00	infobox
Tropomyosin receptor kinase A	Bgee	ganglion of vagus nerve	1.00	infobox
Tropomyosin receptor kinase A	Bgee	superior ganglion of vagus nerve	1.00	infobox
Tropomyosin receptor kinase A	Bgee	superior frontal gyrus	1.00	infobox
Tropomyosin receptor kinase A	BioGPS	More reference expression data	1.00	infobox
Tropomyosin receptor kinase A	Chr.	Chromosome 1 (human)	1.00	infobox
Tropomyosin receptor kinase A	Chr.	Chromosome 3 (mouse)	1.00	infobox
Tropomyosin receptor kinase A	Databases	NCBI: entry; OMA: entry	1.00	infobox
Tropomyosin receptor kinase A	End	156,881,850 bp	1.00	infobox
Tropomyosin receptor kinase A	End	87,702,469 bp	1.00	infobox

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