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Tropomyosin receptor kinase A: Members, Interactions & Function

Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein, is a protein that in humans is encoded by the NTRK1 gene.

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Tropomyosin receptor kinase A topic overview

The analysis highlights Members, Interactions and Function as prominent areas in the source structure around Tropomyosin receptor kinase A. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
59
Source areas
8
Connected nodes
68
Extracted relationships
161
Concept neighborhoods
21
Bridge connections
68

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 12 topics
Function · 8 topics
Ligands · 8 topics
Overview · 8 topics
Role in disease · 8 topics
Role in cancer · 6 topics
Family members · 5 topics
Regulation · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
Aliases
NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS
Band
1q23.1 · 3 F1|3 38.62 cM
Bgee
spinal ganglia · apex of heart · testicle · gonad · right auricle of heart
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Family members

Role in disease

Regulation

Interactions

Ligands

Role in cancer

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Tropomyosin receptor kinase A connects Entity context

The extracted context around Tropomyosin receptor kinase A shows recurring relationship patterns in the source. For example, Tropomyosin receptor kinase A → ageing, ATP binding, axon, axon guidance, axonogenesis involved in innervation, B cell differentiation, behavioral response to formalin induced pain, cell differentiation, cell surface, cellular response to amyloid-beta, cellular response to growth factor stimulus, cellular response to nerve growth factor stimulus, cellular response to nicotine, circadian rhythm, cytoplasm, cytoplasmic vesicle, dendrite, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, early endosome Another extracted example is Tropomyosin receptor kinase A → apex of heart, body of uterus, embryo, ganglion of vagus nerve, glossopharyngeal ganglion, gonad, left uterine tube, left ventricle, lumbar spinal ganglion, muscle layer of sigmoid colon, neural tube, pons, right auricle of heart, spinal ganglia, superior cervical ganglion, superior frontal gyrus, superior ganglion of vagus nerve, testicle, trigeminal ganglion. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tropomyosin receptor kinase A

Top relations

Gene ontology · 96
Tropomyosin receptor kinase A → ageing, ATP binding, axon, axon guidance, axonogenesis involved in innervation, B cell differentiation, behavioral response to formalin induced pain, cell differentiation, cell surface, cellular response to amyloid-beta, cellular response to growth factor stimulus, cellular response to nerve growth factor stimulus, cellular response to nicotine, circadian rhythm, cytoplasm, cytoplasmic vesicle, dendrite, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, early endosome
Bgee · 19
Tropomyosin receptor kinase A → apex of heart, body of uterus, embryo, ganglion of vagus nerve, glossopharyngeal ganglion, gonad, left uterine tube, left ventricle, lumbar spinal ganglion, muscle layer of sigmoid colon, neural tube, pons, right auricle of heart, spinal ganglia, superior cervical ganglion, superior frontal gyrus, superior ganglion of vagus nerve, testicle, trigeminal ganglion
RNA expression pattern · 19
Tropomyosin receptor kinase A → apex of heart, body of uterus, embryo, ganglion of vagus nerve, glossopharyngeal ganglion, gonad, left uterine tube, left ventricle, lumbar spinal ganglion, muscle layer of sigmoid colon, neural tube, pons, right auricle of heart, spinal ganglia, superior cervical ganglion, superior frontal gyrus, superior ganglion of vagus nerve, testicle, trigeminal ganglion
Band · 2
Tropomyosin receptor kinase A → 1q23.1, 3 F1|3 38.62 cM
Chr. · 2
Tropomyosin receptor kinase A → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
Tropomyosin receptor kinase A → 156,881,850 bp, 87,702,469 bp
2.7.10.1 · 1
Tropomyosin receptor kinase A → ↗
Aliases · 1
Tropomyosin receptor kinase A → NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1
Available structures · 1
Tropomyosin receptor kinase A → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS
BioGPS · 1
Tropomyosin receptor kinase A → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

trka gene receptor trk kinase ngf ntrk1 growth trkb human factor tyrosine differentiation bp role nerve cancer trkc neurotrophin binding

Tropomyosin receptor kinase A relationships Subject–Predicate–Object triples

TTTA extracted 161 structured relationships around Tropomyosin receptor kinase A. Examples in this analysis include Tropomyosin receptor kinase A → 2.7.10.1 → ↗ and Tropomyosin receptor kinase A → Aliases → NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tropomyosin receptor kinase A2.7.10.11.00infobox
Tropomyosin receptor kinase AAliasesNTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 11.00infobox
Tropomyosin receptor kinase AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS1.00infobox
Tropomyosin receptor kinase ABand1q23.11.00infobox
Tropomyosin receptor kinase ABand3 F1|3 38.62 cM1.00infobox
Tropomyosin receptor kinase ABgeespinal ganglia1.00infobox
Tropomyosin receptor kinase ABgeeapex of heart1.00infobox
Tropomyosin receptor kinase ABgeetesticle1.00infobox
Tropomyosin receptor kinase ABgeegonad1.00infobox
Tropomyosin receptor kinase ABgeeright auricle of heart1.00infobox
Tropomyosin receptor kinase ABgeeleft uterine tube1.00infobox
Tropomyosin receptor kinase ABgeepons1.00infobox
Tropomyosin receptor kinase ABgeemuscle layer of sigmoid colon1.00infobox
Tropomyosin receptor kinase ABgeeleft ventricle1.00infobox
Tropomyosin receptor kinase ABgeebody of uterus1.00infobox
Tropomyosin receptor kinase ABgeelumbar spinal ganglion1.00infobox
Tropomyosin receptor kinase ABgeesuperior cervical ganglion1.00infobox
Tropomyosin receptor kinase ABgeeneural tube1.00infobox
Tropomyosin receptor kinase ABgeetrigeminal ganglion1.00infobox
Tropomyosin receptor kinase ABgeeglossopharyngeal ganglion1.00infobox
Tropomyosin receptor kinase ABgeeembryo1.00infobox
Tropomyosin receptor kinase ABgeeganglion of vagus nerve1.00infobox
Tropomyosin receptor kinase ABgeesuperior ganglion of vagus nerve1.00infobox
Tropomyosin receptor kinase ABgeesuperior frontal gyrus1.00infobox
Tropomyosin receptor kinase ABioGPSMore reference expression data1.00infobox
Tropomyosin receptor kinase AChr.Chromosome 1 (human)1.00infobox
Tropomyosin receptor kinase AChr.Chromosome 3 (mouse)1.00infobox
Tropomyosin receptor kinase ADatabasesNCBI: entry; OMA: entry1.00infobox
Tropomyosin receptor kinase AEnd156,881,850 bp1.00infobox
Tropomyosin receptor kinase AEnd87,702,469 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Tropomyosin receptor kinase A bring nearby vocabulary together. In this analysis, examples include Receptor, Tyrosine and Ntrk1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Tropomyosin receptor kinase A
    • Receptor
    • Tyrosine
    • Ntrk1
    • Binding
    • Trka
    • Cell
    • Factor
    • Gene
    • Differentiation
    • Ngf
    • Family
    • Neurotrophic
  • tropomyosin receptor kinase a
    • Tyrosine
    • Receptor
    • Ntrk1
    • Gene
    • Binding
    • Trka
    • Cell
    • Factor
    • Neurotrophic
    • Differentiation
    • Ngf
    • Human
  • gene
    • Ntrk1
    • Tyrosine
    • Kinase
    • Human
    • Receptor
    • Chromosome
    • Bp
    • Chr
    • Family
    • Neurotrophic
    • Fusions
    • Trk
  • neurotrophic tyrosine kinase receptor (ntkr) family
    • Kinase
    • Tyrosine
    • Receptor
    • Ntrk1
    • Gene
    • Neurotrophic
    • Binding
    • Trka
    • Activity
    • Cell
    • Chromosome
    • Development
  • catalytic receptor
    • Tyrosine
    • Ntrk1
    • Binding
    • Trka
    • Factor
    • Gene
    • Ngf
    • Family
    • Neurotrophic
    • Nerve
    • Human
    • Trk
  • nerve growth factor
    • Growth
    • Nerve
    • Factor
    • Protein
    • Development
    • One
    • Receptor
    • Found
    • Neurotrophic
    • Tyrosine
    • Study
    • Ngf
  • differentiation
    • Kinase
    • Cancer
    • Tyrosine
    • Trk
    • Mouse
    • Band
    • Chromosome
    • Development
    • May
    • Neurotrophin
    • Ngf
    • Protein
  • programmed cell death
    • Differentiation
    • May
    • Neurotrophin
    • Kinase
    • Ngf
    • Mouse
    • Band
    • Chromosome
    • Development
    • Protein
    • Trk
    • Activity

Connections between topic areas Semantic bridges

For Tropomyosin receptor kinase A, one of the stronger structural bridges in this analysis connects Tropomyosin receptor kinase A with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tropomyosin receptor kinase AInteractions · splits 56 ⟂ 13
Tropomyosin receptor kinase AOverview · splits 60 ⟂ 9
Tropomyosin receptor kinase AFunction · splits 60 ⟂ 9
Tropomyosin receptor kinase ARole in disease · splits 60 ⟂ 9
Tropomyosin receptor kinase ALigands · splits 60 ⟂ 9
Tropomyosin receptor kinase ARole in cancer · splits 62 ⟂ 7
Tropomyosin receptor kinase AFamily members · splits 63 ⟂ 6
Tropomyosin receptor kinase ARegulation · splits 63 ⟂ 6

Map overview Semantic statistics

Tropomyosin receptor kinase A

Nodes69
Edges68
Triples161
Avg. degree1.97
Density0.028986
Components1

Source & methodology

TTTA analyzes the structure around Tropomyosin receptor kinase A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Members, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tropomyosin receptor kinase A · EN edition · Analysis: TopicsToTalkAbout

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