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CCL5

Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. The gene was discovered in 1990 by in situ hybridisation, and it is localised on the 17q11.2-q12 chromosome.

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Aliases
CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Band
17q12 · 11 C|11 50.66 cM
Bgee
granulocyte · monocyte · blood · lymph node · spleen
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Overview

Function

Interactions

Clinical significance

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Map overview Semantic statistics

CCL5

Nodes96
Edges95
Triples195
Avg. degree1.98
Density0.020833
Components1

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CCL5

Top relations

Gene ontology · 90
CCL5 → activation of phospholipase D activity, calcium ion transport, CCR chemokine receptor binding, CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, CCR5 chemokine receptor binding, cell-cell signaling, cellular calcium ion homeostasis, cellular response to fibroblast growth factor stimulus, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to organic cyclic compound, cellular response to tumor necrosis factor, chemoattractant activity, chemokine activity, chemokine receptor antagonist activity, chemokine receptor binding, chemokine-mediated signaling pathway, chemotaxis, cytokine activity
related to Function · 33
CCL5 → After, Akt, Akt/PKB, Although, An, B-cells, Bcl2, Beta-catenin, CC, CC-Chemokine-activated, CCL5/CCR5, CCR1, CCR3, CCR4, CCR5, CD8, CHAK, Cyclin, G-protein, GPCRs
Bgee · 17
CCL5 → appendix, blood, bone marrow, duodenum, epithelium of colon, gallbladder, granulocyte, jejunum, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, right lung, spleen, subcutaneous adipose tissue, superior surface of tongue, thymus
RNA expression pattern · 17
CCL5 → appendix, blood, bone marrow, duodenum, epithelium of colon, gallbladder, granulocyte, jejunum, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, right lung, spleen, subcutaneous adipose tissue, superior surface of tongue, thymus
related to External links · 8
CCL5 → C-C, Human CCL5, Overview, P13501, PDB, PDBe-KB, UCSC Genome Browser, UniProt
related to Interactions · 5
CCL5 → CCR1, CCR3, CCR5, G-protein, GPR75
Band · 2
CCL5 → 11 C|11 50.66 cM, 17q12
Chr. · 2
CCL5 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
CCL5 → 35,880,793 bp, 83,421,344 bp
related to Clinical significance · 2
CCL5 → COVID-19, For

Important terminology Word statistics

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Important terminology

chemokine protein also human gene ccr5 cells expressed bp cell rantes chromosome t-cells binding activation chr band surface receptor factor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CCL5AliasesCCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 51.00infobox
CCL5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY1.00infobox
CCL5Band17q121.00infobox
CCL5Band11 C|11 50.66 cM1.00infobox
CCL5Bgeegranulocyte1.00infobox
CCL5Bgeemonocyte1.00infobox
CCL5Bgeeblood1.00infobox
CCL5Bgeelymph node1.00infobox
CCL5Bgeespleen1.00infobox
CCL5Bgeegallbladder1.00infobox
CCL5Bgeeduodenum1.00infobox
CCL5Bgeeepithelium of colon1.00infobox
CCL5Bgeeappendix1.00infobox
CCL5Bgeebone marrow1.00infobox
CCL5Bgeemesenteric lymph nodes1.00infobox
CCL5Bgeesuperior surface of tongue1.00infobox
CCL5Bgeethymus1.00infobox
CCL5Bgeejejunum1.00infobox
CCL5Bgeesubcutaneous adipose tissue1.00infobox
CCL5BgeePaneth cell1.00infobox
CCL5Bgeeright lung1.00infobox
CCL5BioGPSMore reference expression data1.00infobox
CCL5Chr.Chromosome 17 (human)1.00infobox
CCL5Chr.Chromosome 11 (mouse)1.00infobox
CCL5DatabasesNCBI: entry; OMA: entry1.00infobox
CCL5End35,880,793 bp1.00infobox
CCL5End83,421,344 bp1.00infobox
CCL5EnsemblENSG00000271503 ENSG000002742331.00infobox
CCL5Entrez63521.00infobox
CCL5External IDsOMIM: 187011; MGI: 98262; GeneCards: CCL51.00infobox

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