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Actin

Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass is roughly 42 kDa, with a diameter of 4 to 7 nm.

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Key facts & relationships

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AlphaFold
IPR004000 · PF00022
Available protein structures:
IPR004000 · PF00022
InterPro
IPR004000
PDB
IPR004000 PF00022 (ECOD; PDBsum)
Pfam
PF00022
PROSITE
PDOC00340

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Function

Structure

Assembly dynamics

Genetics

Evolution

Molecular pathology

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Map overview Semantic statistics

Actin

Nodes385
Edges384
Triples266
Avg. degree1.99
Density0.005195
Components1

How this topic connects Entity context

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Actin

Top relations

related to Other pathological mechanisms · 21
Actin → ABPs, Arp2/3, Burkholderia, Different, DNA, Each, Ena/VASP, In, Listeria, Many, Mycobacterium, Other, Pseudomonas, Rickettsia, Shigella, Some, The, This, Through, Two
related to history · 19
Actin → Albert Szent-Györgyi's, ATP, Banga's, Brunó Ferenc Straub, Building, Following, Halliburton, However, Hungary, Ilona Banga, Institute, Medical Chemistry, Realizing, Since Straub's, Straub, Straub's, Szeged, Szent-Györgyi, University
related to ATPase's catalytic mechanism · 14
Actin → ADP, Although, ATP, ATP's, ATPase, ATPase's, Glu137, It, Its, Pi, QM/MM, The, Then, This
related to Equivalents in prokaryotes · 14
Actin → AlfA, Bacteria, DNA, F-actin, FtsA, FtsZ, Furthermore, G-actin, However, MamK, MreB, ParM, ParMs, The
related to Evolution · 13
Actin → Arp1, Arp11, Arps, Bacteria, Earth, FtsA, Humans, In, Many, MreB, ParM, Some, The
related to Structure · 13
Actin → ADP, ATP, ATPase, Binding, Da, G-actin, GTP-binding, Its, Kabsch, Monomeric, The, The G-actin, The X-ray
related to F-actin · 12
Actin → As F-actin, At, ATP-binding, Conversely, F-actin, G-actin, In F-actin, Some, The, These, These F-actin, Under
related to Molecular pathology · 11
Actin → ACTA1, ACTA2, ACTB, ACTC1, ACTG1, ACTG2, F-actin, HIV, Of, The, This
related to Actin binding proteins · 10
Actin → Arp2/3, ATP, Branches, Formins, G-actin, Nucleation, The, Then, These, They
related to Folding · 10
Actin → ATP-dependent, CCT, Eubacteria, GroEL, However, II, It, Nevertheless, Substrates, The

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Important terminology

cell proteins filaments protein also cells myosin muscle cytoskeleton two found different polymerization form mutations microfilaments filament structure processes molecules

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ActinAlphaFoldIPR0040001.00infobox
ActinAlphaFoldPF000221.00infobox
ActinAvailable protein structures:IPR0040001.00infobox
ActinAvailable protein structures:PF000221.00infobox
ActinInterProIPR0040001.00infobox
ActinPDBIPR004000 PF00022 (ECOD; PDBsum)1.00infobox
ActinPfamPF000221.00infobox
ActinPROSITEPDOC003401.00infobox
ActinSCOP22btf / SCOPe / SUPFAM1.00infobox
ActinSymbolActin1.00infobox
Actincausesdiseases0.90text
Actinis afamily of globular multi-functional proteins that form microfilaments in the cytoskeleton0.90text
Actinis amolecule that integrates cytoplasmic and nuclear signal transduction pathways0.90text
Actinis amost abundant protein found in human tissue0.90text
Actinlocated inthe smooth muscle0.90text

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