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Anaplastic large-cell lymphoma

Anaplastic large-cell lymphoma (ALCL) refers to a group of non-Hodgkin lymphomas in which aberrant T cells proliferate uncontrollably. Considered as a single entity, ALCL is the most common type of peripheral lymphoma and represents ~10% of all peripheral lymphomas in children. The incidence of ALCL is estimated to be 0.25 cases per 100,000 people in the…

ALK-positive anaplastic large-cell lymphoma, Diagnosis & Gene and molecular abnormalities

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Other names
ACL
Specialty
Hematology, oncology
Types
ALK-positive ALCL, ALK-negative ALCL, primary cutaneous ALCL, breast implant-associated ALCL

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Overview

ALK-positive anaplastic large-cell lymphoma

Signs and symptoms

Diagnosis

Gene and molecular abnormalities

Treatment and prognosis

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Anaplastic large-cell lymphoma

Nodes144
Edges143
Triples18
Avg. degree1.99
Density0.013889
Components1

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Anaplastic large-cell lymphoma

Top relations

Other names · 1
Anaplastic large-cell lymphoma → ACL
Specialty · 1
Anaplastic large-cell lymphoma → Hematology, oncology
Types · 1
Anaplastic large-cell lymphoma → ALK-positive ALCL, ALK-negative ALCL, primary cutaneous ALCL, breast implant-associated ALCL

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Important terminology

alcl cells cases gene alk patients alk-positive disease alk-negative bia-alcl breast individuals pcalcl lymphomas may lymphoma lesions therapy proteins various

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Anaplastic large-cell lymphomaOther namesACL1.00infobox
Anaplastic large-cell lymphomaSpecialtyHematology, oncology1.00infobox
Anaplastic large-cell lymphomaTypesALK-positive ALCL, ALK-negative ALCL, primary cutaneous ALCL, breast implant-associated ALCL1.00infobox
feverinstance ofThey evidence systemic symptoms including B symptoms0.80text
night sweatsinstance ofThey evidence systemic symptoms including B symptoms0.80text
and weight loss in 75instance ofThey evidence systemic symptoms including B symptoms0.80text
GDPinstance ofpatients who fail or relapse on these treatments are given salvage therapy regimens that have been used for relapsed or refractory aggressive B cell malignancies0.80text
the skininstance ofof patients with ALK-ALCL present with extra-nodal disease in sites0.80text
boneinstance ofof patients with ALK-ALCL present with extra-nodal disease in sites0.80text
and soft tissuesinstance ofof patients with ALK-ALCL present with extra-nodal disease in sites0.80text
various carcinomasinstance ofT-cell lineage0.80text
small lymphocytesinstance ofa variety of non-malignant cells0.80text

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