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Janus kinase 1

Janus kinase 1 (JAK1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor…

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2.7.10.2
↗
Aliases
JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8,…
Band
1p31.3 · 4 C6|4 46.19 cM
Bgee
beta cell · skin of hip · Achilles tendon · epithelium of nasopharynx · lymph node
BioGPS
More reference expression data

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Janus kinase 1

Nodes42
Edges41
Triples127
Avg. degree1.95
Density0.047619
Components1

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Janus kinase 1

Top relations

Gene ontology · 52
Janus kinase 1 → ATP binding, CCR5 chemokine receptor binding, cell differentiation, cell migration, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, endomembrane system, endosome, extrinsic component of cytoplasmic side of plasma membrane, focal adhesion, growth hormone receptor binding, innate immune response, interferon-gamma-mediated signaling pathway, interleukin-12-mediated signaling pathway, interleukin-15-mediated signaling pathway, interleukin-2-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-27-mediated signaling pathway
Bgee · 19
Janus kinase 1 → Achilles tendon, ankle, beta cell, blood, cartilage tissue, epithelium of nasopharynx, gastrula, glutes, granulocyte, lymph node, mesenteric lymph nodes, parietal pleura, skin of hip, skin of thigh, sternocleidomastoid muscle, superficial temporal artery, temporal muscle, tibiofemoral joint, triceps brachii muscle
RNA expression pattern · 19
Janus kinase 1 → Achilles tendon, ankle, beta cell, blood, cartilage tissue, epithelium of nasopharynx, gastrula, glutes, granulocyte, lymph node, mesenteric lymph nodes, parietal pleura, skin of hip, skin of thigh, sternocleidomastoid muscle, superficial temporal artery, temporal muscle, tibiofemoral joint, triceps brachii muscle
related to Interactions · 12
Janus kinase 1 → ELP2, GNB2L1IL6ST, Grb2, IL10RA, IL2RB, IRS1, Janus, PTPN11, STAM2, STAT3, STAT5A, STAT5B
Band · 2
Janus kinase 1 → 1p31.3, 4 C6|4 46.19 cM
Chr. · 2
Janus kinase 1 → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
Janus kinase 1 → 101,265,282 bp, 65,067,754 bp
2.7.10.2 · 1
Janus kinase 1 → ↗
Aliases · 1
Janus kinase 1 → JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE
Available structures · 1
Janus kinase 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8,…

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Important terminology

jak1 receptor human bp family chr type band kinase chromosome cytokine janus gene location ii receptors also mouse tyrosine protein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Janus kinase 12.7.10.2↗1.00infobox
Janus kinase 1AliasesJAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE1.00infobox
Janus kinase 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8,…1.00infobox
Janus kinase 1Band1p31.31.00infobox
Janus kinase 1Band4 C6|4 46.19 cM1.00infobox
Janus kinase 1Bgeebeta cell1.00infobox
Janus kinase 1Bgeeskin of hip1.00infobox
Janus kinase 1BgeeAchilles tendon1.00infobox
Janus kinase 1Bgeeepithelium of nasopharynx1.00infobox
Janus kinase 1Bgeelymph node1.00infobox
Janus kinase 1Bgeecartilage tissue1.00infobox
Janus kinase 1Bgeesuperficial temporal artery1.00infobox
Janus kinase 1Bgeeskin of thigh1.00infobox
Janus kinase 1Bgeeparietal pleura1.00infobox
Janus kinase 1Bgeeglutes1.00infobox
Janus kinase 1Bgeetibiofemoral joint1.00infobox
Janus kinase 1Bgeegastrula1.00infobox
Janus kinase 1Bgeetriceps brachii muscle1.00infobox
Janus kinase 1Bgeegranulocyte1.00infobox
Janus kinase 1Bgeemesenteric lymph nodes1.00infobox
Janus kinase 1Bgeeankle1.00infobox
Janus kinase 1Bgeesternocleidomastoid muscle1.00infobox
Janus kinase 1Bgeeblood1.00infobox
Janus kinase 1Bgeetemporal muscle1.00infobox
Janus kinase 1BioGPSMore reference expression data1.00infobox
Janus kinase 1Chr.Chromosome 1 (human)1.00infobox
Janus kinase 1Chr.Chromosome 4 (mouse)1.00infobox
Janus kinase 1DatabasesNCBI: entry; OMA: entry1.00infobox
Janus kinase 1End65,067,754 bp1.00infobox
Janus kinase 1End101,265,282 bp1.00infobox

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