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Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.
The analysis highlights Research, Clinical significance and Function as prominent areas in the source structure around ROS1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around ROS1 shows recurring relationship patterns in the source. For example, ROS1 → ATP binding, cell differentiation, cell population proliferation, cell surface, columnar/cuboidal epithelial cell development, cytoplasm, integral component of membrane, integral component of plasma membrane, kinase activity, membrane, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of signal transduction, nucleotide binding, peptidyl-tyrosine autophosphorylation, perinuclear region of cytoplasm, phosphorylation, plasma membrane, positive regulation of ERK1 and ERK2 cascade, protein binding Another extracted example is ROS1 → ALK, An, Cabometyx, Cabozantinib, Ceritinib, Cometriq, Crizotinib, DS-6051b, Entrectinib, However, Ignyta, In, Inc, It, Lorlatinib, March, NSCLC, NTRK, NTRK1-3, PF-06463922. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
kinase patients tyrosine gene crizotinib cancer nsclc clinical cell receptor alk lung protein activity bp proto-oncogene cancers fusions chr human
TTTA extracted 180 structured relationships around ROS1. Examples in this analysis include ROS1 → 2.7.10.1 → ↗ and ROS1 → Aliases → ROS1, MCF3, ROS, c-ros-1, ROS proto-oncogene 1, receptor tyrosine kinase. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ROS1 | 2.7.10.1 | ↗ | 1.00 | infobox |
| ROS1 | Aliases | ROS1, MCF3, ROS, c-ros-1, ROS proto-oncogene 1, receptor tyrosine kinase | 1.00 | infobox |
| ROS1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ZBF, 4UXL | 1.00 | infobox |
| ROS1 | Band | 6q22.1 | 1.00 | infobox |
| ROS1 | Band | 10 B3|10 26.18 cM | 1.00 | infobox |
| ROS1 | Bgee | upper lobe of left lung | 1.00 | infobox |
| ROS1 | Bgee | corpus epididymis | 1.00 | infobox |
| ROS1 | Bgee | right lung | 1.00 | infobox |
| ROS1 | Bgee | lower lobe of lung | 1.00 | infobox |
| ROS1 | Bgee | testicle | 1.00 | infobox |
| ROS1 | Bgee | muscle of thigh | 1.00 | infobox |
| ROS1 | Bgee | visceral pleura | 1.00 | infobox |
| ROS1 | Bgee | decidua | 1.00 | infobox |
| ROS1 | Bgee | caput epididymis | 1.00 | infobox |
| ROS1 | Bgee | Brodmann area 9 | 1.00 | infobox |
| ROS1 | Bgee | semen | 1.00 | infobox |
| ROS1 | Bgee | epithelium of small intestine | 1.00 | infobox |
| ROS1 | Bgee | ileum | 1.00 | infobox |
| ROS1 | Bgee | duodenum | 1.00 | infobox |
| ROS1 | Bgee | precursor cell | 1.00 | infobox |
| ROS1 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| ROS1 | Bgee | migratory enteric neural crest cell | 1.00 | infobox |
| ROS1 | Bgee | spermatid | 1.00 | infobox |
| ROS1 | Bgee | submandibular gland | 1.00 | infobox |
| ROS1 | Bgee | central gray substance of midbrain | 1.00 | infobox |
| ROS1 | BioGPS | More reference expression data | 1.00 | infobox |
| ROS1 | Chr. | Chromosome 6 (human) | 1.00 | infobox |
| ROS1 | Chr. | Chromosome 10 (mouse) | 1.00 | infobox |
| ROS1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ROS1 | End | 117,425,942 bp | 1.00 | infobox |
The concept neighborhoods around ROS1 bring nearby vocabulary together. In this analysis, examples include Patients, Lung and Fusions. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ROS1, one of the stronger structural bridges in this analysis connects ROS1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ROS1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ROS1 · EN edition · Analysis: TopicsToTalkAbout