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ROS1

Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.

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2.7.10.1
Aliases
ROS1, MCF3, ROS, c-ros-1, ROS proto-oncogene 1, receptor tyrosine kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ZBF, 4UXL
Band
6q22.1 · 10 B3|10 26.18 cM
Bgee
upper lobe of left lung · corpus epididymis · right lung · lower lobe of lung · testicle
BioGPS
More reference expression data

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Function

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Map overview Semantic statistics

ROS1

Nodes41
Edges40
Triples180
Avg. degree1.95
Density0.04878
Components1

How this topic connects Entity context

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ROS1

Top relations

Gene ontology · 36
ROS1 → ATP binding, cell differentiation, cell population proliferation, cell surface, columnar/cuboidal epithelial cell development, cytoplasm, integral component of membrane, integral component of plasma membrane, kinase activity, membrane, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of signal transduction, nucleotide binding, peptidyl-tyrosine autophosphorylation, perinuclear region of cytoplasm, phosphorylation, plasma membrane, positive regulation of ERK1 and ERK2 cascade, protein binding
related to As a drug target · 32
ROS1 → ALK, An, Cabometyx, Cabozantinib, Ceritinib, Cometriq, Crizotinib, DS-6051b, Entrectinib, However, Ignyta, In, Inc, It, Lorlatinib, March, NSCLC, NTRK, NTRK1-3, PF-06463922
Bgee · 20
ROS1 → Brodmann area 9, caput epididymis, central gray substance of midbrain, corpus epididymis, decidua, duodenum, epithelium of small intestine, ileum, lower lobe of lung, lumbar subsegment of spinal cord, migratory enteric neural crest cell, muscle of thigh, precursor cell, right lung, semen, spermatid, submandibular gland, testicle, upper lobe of left lung, visceral pleura
RNA expression pattern · 20
ROS1 → Brodmann area 9, caput epididymis, central gray substance of midbrain, corpus epididymis, decidua, duodenum, epithelium of small intestine, ileum, lower lobe of lung, lumbar subsegment of spinal cord, migratory enteric neural crest cell, muscle of thigh, precursor cell, right lung, semen, spermatid, submandibular gland, testicle, upper lobe of left lung, visceral pleura
related to Role in cancer · 14
ROS1 → ALK, Although, Clinical, Crizotinib, EGFR, Gene, In, Nonetheless, NSCLC, Preclinical, RAS, ROS1-positive, Since, The
related to Fusion prevalence · 11
ROS1 → ALK, ALK-rearranged, ALK-rearranged NSCLCs, ALK/ROS1, Asian, In, NSCLC, ROS1-rearranged NSCLC, Similar, Stage IV, There
related to Function · 6
ROS1 → Its, NELL2, Proto-oncogene, ROS, RTK, Upon
related to Research · 6
ROS1 → ALK, Among, From, In, NSCLC, These
related to Structure · 6
ROS1 → ATP-binding, Proto-oncogene, ROS, RTK, Structurally, The
related to The ROS1ders · 4
ROS1 → It, Partners, The ROS1ders, Their

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Important terminology

kinase patients tyrosine gene crizotinib cancer nsclc clinical cell receptor alk lung protein activity bp proto-oncogene cancers fusions chr human

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ROS12.7.10.11.00infobox
ROS1AliasesROS1, MCF3, ROS, c-ros-1, ROS proto-oncogene 1, receptor tyrosine kinase1.00infobox
ROS1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ZBF, 4UXL1.00infobox
ROS1Band6q22.11.00infobox
ROS1Band10 B3|10 26.18 cM1.00infobox
ROS1Bgeeupper lobe of left lung1.00infobox
ROS1Bgeecorpus epididymis1.00infobox
ROS1Bgeeright lung1.00infobox
ROS1Bgeelower lobe of lung1.00infobox
ROS1Bgeetesticle1.00infobox
ROS1Bgeemuscle of thigh1.00infobox
ROS1Bgeevisceral pleura1.00infobox
ROS1Bgeedecidua1.00infobox
ROS1Bgeecaput epididymis1.00infobox
ROS1BgeeBrodmann area 91.00infobox
ROS1Bgeesemen1.00infobox
ROS1Bgeeepithelium of small intestine1.00infobox
ROS1Bgeeileum1.00infobox
ROS1Bgeeduodenum1.00infobox
ROS1Bgeeprecursor cell1.00infobox
ROS1Bgeelumbar subsegment of spinal cord1.00infobox
ROS1Bgeemigratory enteric neural crest cell1.00infobox
ROS1Bgeespermatid1.00infobox
ROS1Bgeesubmandibular gland1.00infobox
ROS1Bgeecentral gray substance of midbrain1.00infobox
ROS1BioGPSMore reference expression data1.00infobox
ROS1Chr.Chromosome 6 (human)1.00infobox
ROS1Chr.Chromosome 10 (mouse)1.00infobox
ROS1DatabasesNCBI: entry; OMA: entry1.00infobox
ROS1End117,425,942 bp1.00infobox

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