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CD2: Function, Interactions & Classification

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.

Language: English [EN]
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CD2 topic overview

The analysis highlights Function, Interactions and Classification as prominent areas in the source structure around CD2.

Related topics
16
Source areas
4
Connected nodes
20
Extracted relationships
104
Concept neighborhoods
7
Bridge connections
20

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 7 topics
Interactions · 4 topics
Overview · 3 topics
Classification · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD2, LFA-2, SRBC, T11, CD2 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I
Band
1p13.1 · 3 F2.2|3 44.17 cM
Bgee
granulocyte · thymus · lymph node · testicle · appendix
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Classification

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD2 connects Entity context

The extracted context around CD2 shows recurring relationship patterns in the source. For example, CD2 → anchored component of plasma membrane, antigen binding, apoptotic process, cell adhesion, cell surface, cell surface receptor signaling pathway, cell-cell adhesion, cell-cell junction, cytoplasmic side of plasma membrane, external side of plasma membrane, extracellular region, heterotypic cell-cell adhesion, integral component of membrane, integral component of plasma membrane, leukocyte migration, membrane, membrane raft, membrane raft polarization, natural killer cell activation, plasma membrane Another extracted example is CD2 → ankle joint, appendix, blood, embryo, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, mucosa of ileum, right lung lobe, spleen, subcutaneous adipose tissue, superficial temporal artery, testicle, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD2

Top relations

Gene ontology · 32
CD2 → anchored component of plasma membrane, antigen binding, apoptotic process, cell adhesion, cell surface, cell surface receptor signaling pathway, cell-cell adhesion, cell-cell junction, cytoplasmic side of plasma membrane, external side of plasma membrane, extracellular region, heterotypic cell-cell adhesion, integral component of membrane, integral component of plasma membrane, leukocyte migration, membrane, membrane raft, membrane raft polarization, natural killer cell activation, plasma membrane
Bgee · 15
CD2 → ankle joint, appendix, blood, embryo, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, mucosa of ileum, right lung lobe, spleen, subcutaneous adipose tissue, superficial temporal artery, testicle, thymus
RNA expression pattern · 15
CD2 → ankle joint, appendix, blood, embryo, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, mucosa of ileum, right lung lobe, spleen, subcutaneous adipose tissue, superficial temporal artery, testicle, thymus
related to External links · 7
CD2 → Antigen, CD Antigen ChartHuman CD2, Medicine Medical Subject Headings, MeSH, Mouse CD Antigen ChartHuman, National Library, UCSC Genome Browser
related to Function · 5
CD2 → CD48, In, It, LFA-3/CD58, NK
related to Interactions · 3
CD2 → CD2BP2, Lck, PSTPIP1
Band · 2
CD2 → 1p13.1, 3 F2.2|3 44.17 cM
Chr. · 2
CD2 → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
CD2 → 101,195,255 bp, 116,769,229 bp
related to Diagnostic relevance · 2
CD2 → NK, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp human chr band antigen chromosome gene location surface cells external mouse cell adhesion molecule nk also differentiation natural killer

CD2 relationships Subject–Predicate–Object triples

TTTA extracted 104 structured relationships around CD2. Examples in this analysis include CD2 → Aliases → CD2, LFA-2, SRBC, T11, CD2 molecule and CD2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD2AliasesCD2, LFA-2, SRBC, T11, CD2 molecule1.00infobox
CD2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I1.00infobox
CD2Band1p13.11.00infobox
CD2Band3 F2.2|3 44.17 cM1.00infobox
CD2Bgeegranulocyte1.00infobox
CD2Bgeethymus1.00infobox
CD2Bgeelymph node1.00infobox
CD2Bgeetesticle1.00infobox
CD2Bgeeappendix1.00infobox
CD2Bgeeblood1.00infobox
CD2Bgeeepithelium of nasopharynx1.00infobox
CD2Bgeesuperficial temporal artery1.00infobox
CD2Bgeespleen1.00infobox
CD2Bgeemucosa of ileum1.00infobox
CD2Bgeemesenteric lymph nodes1.00infobox
CD2Bgeeright lung lobe1.00infobox
CD2Bgeesubcutaneous adipose tissue1.00infobox
CD2Bgeeembryo1.00infobox
CD2Bgeeankle joint1.00infobox
CD2BioGPSMore reference expression data1.00infobox
CD2Chr.Chromosome 1 (human)1.00infobox
CD2Chr.Chromosome 3 (mouse)1.00infobox
CD2DatabasesNCBI: entry; OMA: entry1.00infobox
CD2End116,769,229 bp1.00infobox
CD2End101,195,255 bp1.00infobox
CD2EnsemblENSG000001168241.00infobox
CD2Entrez9141.00infobox
CD2External IDsOMIM: 186990; MGI: 88320; GeneCards: CD21.00infobox
CD2Gene location (Human)Gene location (Human)Chr.Chromosome 1 (human)Band1p13.1Start116,754,430 bpEnd116,769,229 bp1.00infobox
CD2Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 3 (mouse)Band3 F2.2|3 44.17 cMStart101,183,215 bpEnd101,195,255 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD2 bring nearby vocabulary together. In this analysis, examples include Cells, Antigen and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD2
    • Cells
    • Antigen
    • Cell
    • Molecule
    • Nk
    • Gene
    • Location
    • Human
    • Adhesion
    • Differentiation
    • External
    • Extracellular
  • cd2
    • Cells
    • Antigen
    • Cell
    • Molecule
    • Nk
    • Gene
    • Location
    • Human
    • Adhesion
    • Differentiation
    • External
    • Extracellular
  • cell adhesion molecule
    • Differentiation
    • Killer
    • Natural
    • Cell
    • Surface
    • Cells
    • Expressed
    • Nk
    • Antigen
    • End
    • External
    • Extracellular
  • t cells
    • Nk
    • Differentiation
    • Killer
    • Natural
    • Tissue
    • Molecule
    • Surface
    • Expressed
    • End
    • External
    • Extracellular
    • F2
  • natural killer (nk) cells
    • Natural
    • Nk
    • Surface
    • Differentiation
    • Expressed
    • Killer
    • Tissue
    • Molecule
    • End
    • External
    • Extracellular
    • F2
  • function
    • Search
    • Chromosome
    • Expressed
    • Gene
    • Location
    • Bp
    • Chr
    • Human
    • End
    • Extracellular
    • F2
    • Killer
  • extracellular
    • F2
    • Function
    • Killer
    • Lfa-3
    • Natural
    • Receptor
    • Search
    • Tissue
    • Ucsc
    • Mouse
    • Surface
    • Gene

Connections between topic areas Semantic bridges

For CD2, one of the stronger structural bridges in this analysis connects CD2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD2Function · splits 13 ⟂ 8
CD2Interactions · splits 16 ⟂ 5
CD2Overview · splits 17 ⟂ 4
CD2Classification · splits 18 ⟂ 3

Map overview Semantic statistics

CD2

Nodes21
Edges20
Triples104
Avg. degree1.9
Density0.095238
Components1

Source & methodology

TTTA analyzes the structure around CD2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Classification, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD2 · EN edition · Analysis: TopicsToTalkAbout

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