Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

TP63

Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene.

Function, Clinical significance & Diagnostic utility

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around TP63. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein p63
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A9Z, 1RG6, 2RMN, 2Y9T, 2Y9U, 3QYM, 3QYN, 3US0, 3US1, 3US2, 3ZY0, 3ZY1
Band
3q28 · 16 B1|16 17.37 cM
Bgee
skin of thigh · skin of hip · skin of arm · human penis · hair follicle
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Molecular mechanism

Diagnostic utility

Interactions

Regulation

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

TP63

Nodes46
Edges45
Triples210
Avg. degree1.96
Density0.043478
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

TP63

Top relations

Gene ontology · 107
TP63 → ageing, anatomical structure formation involved in morphogenesis, animal organ morphogenesis, apoptotic process, cell differentiation, cell population proliferation, cellular response to DNA damage stimulus, cellular response to UV, chromatin binding, chromatin remodeling, cloacal septation, cranial skeletal system development, cytoplasm, cytosol, damaged DNA binding, dendrite, developmental process, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA-binding transcription activator activity, RNA polymerase II-specific
Bgee · 19
TP63 → conjunctival fornix, corneal stroma, genital tubercle, gingival epithelium, gums, hair follicle, human penis, lip, molar, nipple, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, superior surface of tongue, transitional epithelium of urinary bladder, vulva
RNA expression pattern · 19
TP63 → conjunctival fornix, corneal stroma, genital tubercle, gingival epithelium, gums, hair follicle, human penis, lip, molar, nipple, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, superior surface of tongue, transitional epithelium of urinary bladder, vulva
related to Clinical significance · 15
TP63 → Acro, ADULT, AEC, At, Both, EEC, EEC3, Hay, Mutations, Rap-Hodgkin, Recently, RHS, SHFM4, The, Wells
related to External links · 13
TP63 → AEC Syndrome, AECTP63, Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome, GeneReviews/NCBI/NIH/UW, Hay-Wells Syndrome, Hodgkin SyndromeOMIM, Includes, Medicine Medical Subject Headings, MeSH, National Library, Rapp, TP73L, UCSC Genome Browser
related to Function · 6
TP63 → In, PERP, Recently, TAp63, TP53, Tumor
related to Vulvar cancer · 5
TP63 → Indeed, Induced, IRF6, Vulvar, Vulvar Squamous Cell Carcinoma
related to Interactions · 3
TP63 → HNRPAB, IRF6, It
Band · 2
TP63 → 16 B1|16 17.37 cM, 3q28
Chr. · 2
TP63 → Chromosome 16 (mouse), Chromosome 3 (human)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

p63 gene human cell protein bp p53 also family tumor chr band transcription chromosome skin lip dna squamous cancer location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TP63AliasesTP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein p631.00infobox
TP63Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A9Z, 1RG6, 2RMN, 2Y9T, 2Y9U, 3QYM, 3QYN, 3US0, 3US1, 3US2, 3ZY0, 3ZY11.00infobox
TP63Band3q281.00infobox
TP63Band16 B1|16 17.37 cM1.00infobox
TP63Bgeeskin of thigh1.00infobox
TP63Bgeeskin of hip1.00infobox
TP63Bgeeskin of arm1.00infobox
TP63Bgeehuman penis1.00infobox
TP63Bgeehair follicle1.00infobox
TP63Bgeevulva1.00infobox
TP63Bgeegums1.00infobox
TP63Bgeenipple1.00infobox
TP63Bgeeskin of abdomen1.00infobox
TP63Bgeegingival epithelium1.00infobox
TP63Bgeemolar1.00infobox
TP63Bgeeskin of external ear1.00infobox
TP63Bgeeconjunctival fornix1.00infobox
TP63Bgeeskin of back1.00infobox
TP63Bgeetransitional epithelium of urinary bladder1.00infobox
TP63Bgeecorneal stroma1.00infobox
TP63Bgeelip1.00infobox
TP63Bgeesuperior surface of tongue1.00infobox
TP63Bgeegenital tubercle1.00infobox
TP63BioGPSMore reference expression data1.00infobox
TP63Chr.Chromosome 3 (human)1.00infobox
TP63Chr.Chromosome 16 (mouse)1.00infobox
TP63DatabasesNCBI: entry; OMA: entry1.00infobox
TP63End189,897,276 bp1.00infobox
TP63End25,710,852 bp1.00infobox
TP63EnsemblENSG000000732821.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.