CD4

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CD4 topic overview

The analysis highlights Disease, Function and Structure as prominent areas in the source structure around CD4.

Related topics: 62
Source areas: 4
Connected nodes: 66
Extracted relationships: 206
Concept neighborhoods: 27
Bridge connections: 66

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Disease · 21 topics

Function · 15 topics

Overview · 15 topics

Structure · 11 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CD4, CD4mut, CD4 molecule, OKT4D, IMD79
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT,…
Band: 12p13.31 · 6 F2|6 59.17 cM
Bgee: granulocyte · monocyte · lymph node · spleen · appendix
BioGPS: n/a
Chr.: Chromosome 12 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Molecular biology
Cluster of differentiation
Glycoprotein
Co-receptor
T-cell receptor
Helper T cells Helper T cell
Monocytes
Macrophages
Dendritic cells
Monoclonal antibody Monoclonal antibodies
Gene
CD4+ T helper cells T helper cell
White blood cells Leukocytes
CD8
Killer cells Cytotoxic t cell

Structure

Function

Antigen-presenting cells Antigen-presenting cell
Extracellular
Immunoreceptor tyrosine activation motifs Immunoreceptor tyrosine activation motif
CD3 CD3 (immunology)
SH2 domain
ZAP70
Transcription factors Transcription factor
NF-κB
NFAT
AP-1 AP-1 transcription factor
LAG-3
Negative feedback
Interact Protein-protein interaction
SPG21
Uncoordinated-119 (Unc-119)

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD4 connects Entity context

The extracted context around CD4 shows recurring relationship patterns in the source. For example, CD4 → adaptive immune response, cell adhesion, cell surface, cell surface receptor signaling pathway, cellular response to granulocyte macrophage colony-stimulating factor stimulus, clathrin-coated vesicle membrane, coreceptor activity, cytokine production, cytokine-mediated signaling pathway, defense response to Gram-negative bacterium, early endosome, endoplasmic reticulum lumen, endoplasmic reticulum membrane, enzyme binding, enzyme linked receptor protein signaling pathway, external side of plasma membrane, extracellular matrix structural constituent, fusion of virus membrane with host plasma membrane, helper T cell enhancement of adaptive immune response, identical protein binding Another extracted example is CD4 → AP-1, CD3, Cys-X-Cys/His, D1, II, ITAMs, ITIM-like, LAG-3, Lck, MHC, NF-κB, NFAT, Phosphorylated ITAMs, PTK, SH2, TCR, The, The TCR, These, ZAP70. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 72

CD4 → adaptive immune response, cell adhesion, cell surface, cell surface receptor signaling pathway, cellular response to granulocyte macrophage colony-stimulating factor stimulus, clathrin-coated vesicle membrane, coreceptor activity, cytokine production, cytokine-mediated signaling pathway, defense response to Gram-negative bacterium, early endosome, endoplasmic reticulum lumen, endoplasmic reticulum membrane, enzyme binding, enzyme linked receptor protein signaling pathway, external side of plasma membrane, extracellular matrix structural constituent, fusion of virus membrane with host plasma membrane, helper T cell enhancement of adaptive immune response, identical protein binding

related to Function · 20

CD4 → AP-1, CD3, Cys-X-Cys/His, D1, II, ITAMs, ITIM-like, LAG-3, Lck, MHC, NF-κB, NFAT, Phosphorylated ITAMs, PTK, SH2, TCR, The, The TCR, These, ZAP70

Bgee · 17

CD4 → appendix, blood, external carotid artery, gallbladder, granulocyte, internal carotid artery, lymph node, mesenteric lymph nodes, molar, monocyte, right lobe of liver, right lung, spleen, superior frontal gyrus, thymus, upper lobe of left lung, zygote

RNA expression pattern · 17

related to External links · 16

CD4 → Antigen, CD Antigen Chart Archived, CD1, Glycoprotein, Medicine Medical Subject Headings, MeSH, Mouse CD Antigen ChartHuman, National Library, Overview, P01730, PDB, PDBe-KB, T-cell, UCSC Genome Browser, UniProt, Wayback MachineHuman Immunodeficiency Virus

related to HIV pathology · 12

CD4 → AIDS, DNA, Europe, Health, HIV, HIV-positive, Medical, National Institutes, Normal, Patients, US, While CD4

related to HIV infection · 8

CD4 → CCR5, CXCR4, Following, HIV, HIV-1, T-cells, The, These

related to Other diseases · 7

CD4 → CD3, CD8, It, T-cell, T-cells, The, When

related to Structure · 4

CD4 → D1, D4, It, Like

related to Other interactions · 3

CD4 → SPG21, Unc-119, Uncoordinated-119

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells hiv immune helper human bp cell gene viral surface chr band counts immunoglobulin mhc class protein chromosome 12 infection

CD4 relationships Subject–Predicate–Object triples

TTTA extracted 206 structured relationships around CD4. Examples in this analysis include CD4 → Aliases → CD4, CD4mut, CD4 molecule, OKT4D, IMD79 and CD4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT,…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CD4	Aliases	CD4, CD4mut, CD4 molecule, OKT4D, IMD79	1.00	infobox
CD4	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT,…	1.00	infobox
CD4	Band	12p13.31	1.00	infobox
CD4	Band	6 F2\|6 59.17 cM	1.00	infobox
CD4	Bgee	granulocyte	1.00	infobox
CD4	Bgee	monocyte	1.00	infobox
CD4	Bgee	lymph node	1.00	infobox
CD4	Bgee	spleen	1.00	infobox
CD4	Bgee	appendix	1.00	infobox
CD4	Bgee	gallbladder	1.00	infobox
CD4	Bgee	thymus	1.00	infobox
CD4	Bgee	upper lobe of left lung	1.00	infobox
CD4	Bgee	right lung	1.00	infobox
CD4	Bgee	right lobe of liver	1.00	infobox
CD4	Bgee	mesenteric lymph nodes	1.00	infobox
CD4	Bgee	blood	1.00	infobox
CD4	Bgee	zygote	1.00	infobox
CD4	Bgee	external carotid artery	1.00	infobox
CD4	Bgee	internal carotid artery	1.00	infobox
CD4	Bgee	superior frontal gyrus	1.00	infobox
CD4	Bgee	molar	1.00	infobox
CD4	BioGPS	n/a	1.00	infobox
CD4	Chr.	Chromosome 12 (human)	1.00	infobox
CD4	Chr.	Chromosome 6 (mouse)	1.00	infobox
CD4	Databases	NCBI: entry; OMA: entry	1.00	infobox
CD4	End	6,820,799 bp	1.00	infobox
CD4	End	124,865,184 bp	1.00	infobox
CD4	Ensembl	ENSG00000010610	1.00	infobox
CD4	Entrez	920	1.00	infobox
CD4	External IDs	OMIM: 186940; MGI: 88335; GeneCards: CD4	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD4 bring nearby vocabulary together. In this analysis, examples include Cells, Counts and Class. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CD4
- Cells
- Counts
- Class
- Mhc
- Hiv
- Viral
- Ii
- Helper
- Immune
- Expressed
- Infection
- Needed
cd4
- Cells
- Counts
- Class
- Mhc
- Hiv
- Viral
- Ii
- Helper
- Immune
- Expressed
- Infection
- Needed
t-cell receptor
- Tcr
- Tyrosine
- Class
- Mhc
- Cell
- External
- Blood
- Extracellular
- Mouse
- Band
- Chromosome
- Expressed
helper t cells
- Immune
- Helper
- Blood
- Expressed
- System
- Surface
- Human
- Hiv
- External
- Cd8
- Extracellular
- Infection
gene
- Location
- Mouse
- Human
- Chromosome
- Bp
- Chr
- External
- Band
- Protein
- Blood
- Extracellular
- Glycoprotein
cd4+ t helper cells
- Immune
- Cells
- Helper
- Blood
- Expressed
- System
- Surface
- Counts
- Human
- Class
- Mhc
- Hiv
white blood cells
- System
- Immune
- Expressed
- Helper
- Human
- External
- Viral
- Extracellular
- Mouse
- Band
- Chromosome
- Hiv
mhc class ii
- Class
- Mhc
- Ii
- D1
- Extracellular
- Receptor
- Surface
- Tcr
- Tyrosine
- External
- Mouse
- Co-receptor

Connections between topic areas Semantic bridges

For CD4, one of the stronger structural bridges in this analysis connects CD4 with Disease. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CD4 — Disease · splits 45 ⟂ 22

CD4 — Overview · splits 51 ⟂ 16

CD4 — Function · splits 51 ⟂ 16

CD4 — Structure · splits 55 ⟂ 12

Map overview Semantic statistics

CD4

Nodes67

Edges66

Triples206

Avg. degree1.97

Density0.029851

Components1

Source & methodology

TTTA analyzes the structure around CD4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Disease, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD4 · EN edition · Analysis: TopicsToTalkAbout