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CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal…

Disease, Function & Structure

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Aliases
CD4, CD4mut, CD4 molecule, OKT4D, IMD79
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT,…
Band
12p13.31 · 6 F2|6 59.17 cM
Bgee
granulocyte · monocyte · lymph node · spleen · appendix
BioGPS
n/a
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

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Disease

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Map overview Semantic statistics

CD4

Nodes67
Edges66
Triples206
Avg. degree1.97
Density0.029851
Components1

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CD4

Top relations

Gene ontology · 72
CD4 → adaptive immune response, cell adhesion, cell surface, cell surface receptor signaling pathway, cellular response to granulocyte macrophage colony-stimulating factor stimulus, clathrin-coated vesicle membrane, coreceptor activity, cytokine production, cytokine-mediated signaling pathway, defense response to Gram-negative bacterium, early endosome, endoplasmic reticulum lumen, endoplasmic reticulum membrane, enzyme binding, enzyme linked receptor protein signaling pathway, external side of plasma membrane, extracellular matrix structural constituent, fusion of virus membrane with host plasma membrane, helper T cell enhancement of adaptive immune response, identical protein binding
related to Function · 20
CD4 → AP-1, CD3, Cys-X-Cys/His, D1, II, ITAMs, ITIM-like, LAG-3, Lck, MHC, NF-κB, NFAT, Phosphorylated ITAMs, PTK, SH2, TCR, The, The TCR, These, ZAP70
Bgee · 17
CD4 → appendix, blood, external carotid artery, gallbladder, granulocyte, internal carotid artery, lymph node, mesenteric lymph nodes, molar, monocyte, right lobe of liver, right lung, spleen, superior frontal gyrus, thymus, upper lobe of left lung, zygote
RNA expression pattern · 17
CD4 → appendix, blood, external carotid artery, gallbladder, granulocyte, internal carotid artery, lymph node, mesenteric lymph nodes, molar, monocyte, right lobe of liver, right lung, spleen, superior frontal gyrus, thymus, upper lobe of left lung, zygote
related to External links · 16
CD4 → Antigen, CD Antigen Chart Archived, CD1, Glycoprotein, Medicine Medical Subject Headings, MeSH, Mouse CD Antigen ChartHuman, National Library, Overview, P01730, PDB, PDBe-KB, T-cell, UCSC Genome Browser, UniProt, Wayback MachineHuman Immunodeficiency Virus
related to HIV pathology · 12
CD4 → AIDS, DNA, Europe, Health, HIV, HIV-positive, Medical, National Institutes, Normal, Patients, US, While CD4
related to HIV infection · 8
CD4 → CCR5, CXCR4, Following, HIV, HIV-1, T-cells, The, These
related to Other diseases · 7
CD4 → CD3, CD8, It, T-cell, T-cells, The, When
related to Structure · 4
CD4 → D1, D4, It, Like
related to Other interactions · 3
CD4 → SPG21, Unc-119, Uncoordinated-119

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Important terminology

cells hiv immune helper human bp cell gene viral surface chr band counts immunoglobulin mhc class protein chromosome 12 infection

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD4AliasesCD4, CD4mut, CD4 molecule, OKT4D, IMD791.00infobox
CD4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1Q68, 1RZJ, 1RZK, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT,…1.00infobox
CD4Band12p13.311.00infobox
CD4Band6 F2|6 59.17 cM1.00infobox
CD4Bgeegranulocyte1.00infobox
CD4Bgeemonocyte1.00infobox
CD4Bgeelymph node1.00infobox
CD4Bgeespleen1.00infobox
CD4Bgeeappendix1.00infobox
CD4Bgeegallbladder1.00infobox
CD4Bgeethymus1.00infobox
CD4Bgeeupper lobe of left lung1.00infobox
CD4Bgeeright lung1.00infobox
CD4Bgeeright lobe of liver1.00infobox
CD4Bgeemesenteric lymph nodes1.00infobox
CD4Bgeeblood1.00infobox
CD4Bgeezygote1.00infobox
CD4Bgeeexternal carotid artery1.00infobox
CD4Bgeeinternal carotid artery1.00infobox
CD4Bgeesuperior frontal gyrus1.00infobox
CD4Bgeemolar1.00infobox
CD4BioGPSn/a1.00infobox
CD4Chr.Chromosome 12 (human)1.00infobox
CD4Chr.Chromosome 6 (mouse)1.00infobox
CD4DatabasesNCBI: entry; OMA: entry1.00infobox
CD4End6,820,799 bp1.00infobox
CD4End124,865,184 bp1.00infobox
CD4EnsemblENSG000000106101.00infobox
CD4Entrez9201.00infobox
CD4External IDsOMIM: 186940; MGI: 88335; GeneCards: CD41.00infobox

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