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Tropomyosin receptor kinase B: Members, Ligands & Function

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF).

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Tropomyosin receptor kinase B topic overview

The analysis highlights Members, Ligands and Function as prominent areas in the source structure around Tropomyosin receptor kinase B.

Related topics
82
Source areas
6
Connected nodes
88
Extracted relationships
166
Concept neighborhoods
22
Bridge connections
88

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Ligands · 34 topics
Function · 18 topics
Clinical Implications · 16 topics
Interactions · 6 topics
Family members · 5 topics
Overview · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
Aliases
NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4
Band
9q21.33 · 13 B1|13 31.2 cM
Bgee
optic nerve · external globus pallidus · Region I of hippocampus proper · internal globus pallidus · Epithelium of choroid plexus
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Family members

Clinical Implications

Ligands

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Tropomyosin receptor kinase B connects Entity context

The extracted context around Tropomyosin receptor kinase B shows recurring relationship patterns in the source. For example, Tropomyosin receptor kinase B → activation of phospholipase C activity, ATP binding, axon, axon terminus, brain-derived neurotrophic factor binding, brain-derived neurotrophic factor receptor signaling pathway, brain-derived neurotrophic factor-activated receptor activity, cell differentiation, cell projection, cellular response to amino acid stimulus, cellular response to brain-derived neurotrophic factor stimulus, cellular response to nerve growth factor stimulus, central nervous system neuron development, cerebral cortex development, circadian rhythm, cytoplasm, cytosol, dendrite, dendritic spine, early endosome Another extracted example is Tropomyosin receptor kinase B → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, Epithelium of choroid plexus, external globus pallidus, internal globus pallidus, lateral septal nucleus, median eminence, optic nerve, pars reticulata, postcentral gyrus, Region I of hippocampus proper, subiculum, substantia nigra, superior frontal gyrus, superior vestibular nucleus, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tropomyosin receptor kinase B

Top relations

Gene ontology · 89
Tropomyosin receptor kinase B → activation of phospholipase C activity, ATP binding, axon, axon terminus, brain-derived neurotrophic factor binding, brain-derived neurotrophic factor receptor signaling pathway, brain-derived neurotrophic factor-activated receptor activity, cell differentiation, cell projection, cellular response to amino acid stimulus, cellular response to brain-derived neurotrophic factor stimulus, cellular response to nerve growth factor stimulus, central nervous system neuron development, cerebral cortex development, circadian rhythm, cytoplasm, cytosol, dendrite, dendritic spine, early endosome
Bgee · 19
Tropomyosin receptor kinase B → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, Epithelium of choroid plexus, external globus pallidus, internal globus pallidus, lateral septal nucleus, median eminence, optic nerve, pars reticulata, postcentral gyrus, Region I of hippocampus proper, subiculum, substantia nigra, superior frontal gyrus, superior vestibular nucleus, ventral tegmental area
RNA expression pattern · 19
Tropomyosin receptor kinase B → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, Epithelium of choroid plexus, external globus pallidus, internal globus pallidus, lateral septal nucleus, median eminence, optic nerve, pars reticulata, postcentral gyrus, Region I of hippocampus proper, subiculum, substantia nigra, superior frontal gyrus, superior vestibular nucleus, ventral tegmental area
related to Function · 14
Tropomyosin receptor kinase B → As, BDNF, Brain Derived Neurotrophic Factor, IGF1, MuSK, NT-3, NT-4, Other, The, The TrkB, TrkB, Tropomyosin, Vascular Endothelial Growth Factor, VEGF
Band · 2
Tropomyosin receptor kinase B → 13 B1|13 31.2 cM, 9q21.33
Chr. · 2
Tropomyosin receptor kinase B → Chromosome 13 (mouse), Chromosome 9 (human)
End · 2
Tropomyosin receptor kinase B → 59,281,784 bp, 85,027,070 bp
2.7.10.1 · 1
Tropomyosin receptor kinase B → ↗
Aliases · 1
Tropomyosin receptor kinase B → NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
Available structures · 1
Tropomyosin receptor kinase B → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

trkb bdnf receptor kinase neurotrophic nt-3 tyrosine human bp protein gene factor ntrk2 chr band binding growth nt-4 trkc shown

Tropomyosin receptor kinase B relationships Subject–Predicate–Object triples

TTTA extracted 166 structured relationships around Tropomyosin receptor kinase B. Examples in this analysis include Tropomyosin receptor kinase B → 2.7.10.1 → ↗ and Tropomyosin receptor kinase B → Aliases → NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tropomyosin receptor kinase B2.7.10.11.00infobox
Tropomyosin receptor kinase BAliasesNTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE581.00infobox
Tropomyosin receptor kinase BAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT41.00infobox
Tropomyosin receptor kinase BBand9q21.331.00infobox
Tropomyosin receptor kinase BBand13 B1|13 31.2 cM1.00infobox
Tropomyosin receptor kinase BBgeeoptic nerve1.00infobox
Tropomyosin receptor kinase BBgeeexternal globus pallidus1.00infobox
Tropomyosin receptor kinase BBgeeRegion I of hippocampus proper1.00infobox
Tropomyosin receptor kinase BBgeeinternal globus pallidus1.00infobox
Tropomyosin receptor kinase BBgeeEpithelium of choroid plexus1.00infobox
Tropomyosin receptor kinase BBgeesuperior vestibular nucleus1.00infobox
Tropomyosin receptor kinase BBgeedorsal motor nucleus of vagus nerve1.00infobox
Tropomyosin receptor kinase BBgeeventral tegmental area1.00infobox
Tropomyosin receptor kinase BBgeepostcentral gyrus1.00infobox
Tropomyosin receptor kinase BBgeepars reticulata1.00infobox
Tropomyosin receptor kinase BBgeemedian eminence1.00infobox
Tropomyosin receptor kinase BBgeearcuate nucleus1.00infobox
Tropomyosin receptor kinase BBgeedorsomedial hypothalamic nucleus1.00infobox
Tropomyosin receptor kinase BBgeelateral septal nucleus1.00infobox
Tropomyosin receptor kinase BBgeesuperior frontal gyrus1.00infobox
Tropomyosin receptor kinase BBgeesubstantia nigra1.00infobox
Tropomyosin receptor kinase BBgeesubiculum1.00infobox
Tropomyosin receptor kinase BBgeeanterior amygdaloid area1.00infobox
Tropomyosin receptor kinase BBgeedorsal tegmental nucleus1.00infobox
Tropomyosin receptor kinase BBioGPSMore reference expression data1.00infobox
Tropomyosin receptor kinase BChr.Chromosome 9 (human)1.00infobox
Tropomyosin receptor kinase BChr.Chromosome 13 (mouse)1.00infobox
Tropomyosin receptor kinase BDatabasesNCBI: entry; OMA: entry1.00infobox
Tropomyosin receptor kinase BEnd85,027,070 bp1.00infobox
Tropomyosin receptor kinase BEnd59,281,784 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Tropomyosin receptor kinase B bring nearby vocabulary together. In this analysis, examples include Tyrosine, Receptor and Ntrk2. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Tropomyosin receptor kinase B
    • Tyrosine
    • Receptor
    • Ntrk2
    • Gene
    • Protein
    • Growth
    • Neurotrophic
    • Activity
    • Factor
    • External
    • Also
    • Trkb
  • tropomyosin receptor kinase b
    • Tyrosine
    • Receptor
    • Ntrk2
    • Gene
    • Protein
    • Growth
    • Neurotrophic
    • Activity
    • External
    • Also
    • Factor
    • Chromosome
  • protein
    • Receptor
    • Tyrosine
    • Activity
    • Neuronal
    • Ntrk2
    • Gene
    • Factor
    • External
    • Differentiation
    • Band
    • Brain-derived
    • Cell
  • gene
    • Ntrk2
    • Human
    • Chromosome
    • Bp
    • Chr
    • Kinase
    • Tyrosine
    • External
    • Receptor
    • Band
    • Growth
    • Mouse
  • brain-derived neurotrophic factor
    • Factor
    • Neurotrophic
    • Brain-derived
    • Growth
    • Nt-4
    • Nt-3
    • Ntrk2
    • Gene
    • Receptor
    • External
    • Factors
    • Trkb
  • catalytic receptor
    • Tyrosine
    • Ntrk2
    • Gene
    • Protein
    • Growth
    • Neurotrophic
    • Activity
    • Factor
    • External
    • Also
    • Trkb
    • Bdnf
  • bdnf
    • Trkb
    • Neurotrophic
    • Factor
    • Nt-3
    • Nt-4
    • Brain-derived
    • Pathway
    • Receptor
    • Factors
    • Growth
    • Mouse
    • Neurodegenerative
  • receptor tyrosine kinases
    • Kinase
    • Receptor
    • Tyrosine
    • Ntrk2
    • Gene
    • Protein
    • Growth
    • Neurotrophic
    • Activity
    • External
    • Also
    • Factor

Connections between topic areas Semantic bridges

For Tropomyosin receptor kinase B, one of the stronger structural bridges in this analysis connects Tropomyosin receptor kinase B with Ligands. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tropomyosin receptor kinase BLigands · splits 54 ⟂ 35
Tropomyosin receptor kinase BFunction · splits 70 ⟂ 19
Tropomyosin receptor kinase BClinical Implications · splits 72 ⟂ 17
Tropomyosin receptor kinase BInteractions · splits 82 ⟂ 7
Tropomyosin receptor kinase BFamily members · splits 83 ⟂ 6
Tropomyosin receptor kinase BOverview · splits 85 ⟂ 4

Map overview Semantic statistics

Tropomyosin receptor kinase B

Nodes89
Edges88
Triples166
Avg. degree1.98
Density0.022472
Components1

Source & methodology

TTTA analyzes the structure around Tropomyosin receptor kinase B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Members, Ligands & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tropomyosin receptor kinase B · EN edition · Analysis: TopicsToTalkAbout

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