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Neurotrophin-3: Mechanism of action, Function & Overview

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.

Language: English [EN]
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Neurotrophin-3 topic overview

The analysis highlights Mechanism of action, Function and Overview as prominent areas in the source structure around Neurotrophin-3.

Related topics
25
Source areas
3
Connected nodes
28
Extracted relationships
102
Concept neighborhoods
14
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 10 topics
Mechanism of action · 8 topics
Function · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B8K, 1BND, 1NT3, 3BUK
Band
12p13.31 · 6 F3|6 60.45 cM
Bgee
popliteal artery · tibial arteries · right coronary artery · ascending aorta · left coronary artery
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Mechanism of action

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Neurotrophin-3 connects Entity context

The extracted context around Neurotrophin-3 shows recurring relationship patterns in the source. For example, Neurotrophin-3 → activation of GTPase activity, activation of protein kinase B activity, axon, cell-cell signaling, chemoattractant activity, cytoplasmic vesicle, dendrite, extracellular region, extracellular space, growth factor activity, induction of positive chemotaxis, memory, modulation of chemical synaptic transmission, negative regulation of neuron apoptotic process, negative regulation of peptidyl-tyrosine phosphorylation, nerve development, nerve growth factor signaling pathway, nervous system development, neuron projection morphogenesis, neurotrophin p75 receptor binding Another extracted example is Neurotrophin-3 → ascending aorta, ciliary body, conjunctival fornix, corneal stroma, Descending thoracic aorta, external naris, iris, left coronary artery, left ovary, maxillary prominence, medullary collecting duct, pineal gland, popliteal artery, right coronary artery, right ovary, saphenous vein, substantia nigra, testicle, tibial arteries. Use these groups to spot repeated connection types before inspecting the individual relationships.

Neurotrophin-3

Top relations

Gene ontology · 40
Neurotrophin-3 → activation of GTPase activity, activation of protein kinase B activity, axon, cell-cell signaling, chemoattractant activity, cytoplasmic vesicle, dendrite, extracellular region, extracellular space, growth factor activity, induction of positive chemotaxis, memory, modulation of chemical synaptic transmission, negative regulation of neuron apoptotic process, negative regulation of peptidyl-tyrosine phosphorylation, nerve development, nerve growth factor signaling pathway, nervous system development, neuron projection morphogenesis, neurotrophin p75 receptor binding
Bgee · 19
Neurotrophin-3 → ascending aorta, ciliary body, conjunctival fornix, corneal stroma, Descending thoracic aorta, external naris, iris, left coronary artery, left ovary, maxillary prominence, medullary collecting duct, pineal gland, popliteal artery, right coronary artery, right ovary, saphenous vein, substantia nigra, testicle, tibial arteries
RNA expression pattern · 19
Neurotrophin-3 → ascending aorta, ciliary body, conjunctival fornix, corneal stroma, Descending thoracic aorta, external naris, iris, left coronary artery, left ovary, maxillary prominence, medullary collecting duct, pineal gland, popliteal artery, right coronary artery, right ovary, saphenous vein, substantia nigra, testicle, tibial arteries
Band · 2
Neurotrophin-3 → 12p13.31, 6 F3|6 60.45 cM
Chr. · 2
Neurotrophin-3 → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
Neurotrophin-3 → 126,143,873 bp, 5,521,536 bp
Aliases · 1
Neurotrophin-3 → NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3
Available structures · 1
Neurotrophin-3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B8K, 1BND, 1NT3, 3BUK
BioGPS · 1
Neurotrophin-3 → More reference expression data
Databases · 1
Neurotrophin-3 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nt-3 factor growth gene bp receptors protein lngfr receptor nerve chr human band neurotrophin chromosome 12 ngf ntf3 trk neurons

Neurotrophin-3 relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around Neurotrophin-3. Examples in this analysis include Neurotrophin-3 → Aliases → NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3 and Neurotrophin-3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B8K, 1BND, 1NT3, 3BUK. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Neurotrophin-3AliasesNTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 31.00infobox
Neurotrophin-3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B8K, 1BND, 1NT3, 3BUK1.00infobox
Neurotrophin-3Band12p13.311.00infobox
Neurotrophin-3Band6 F3|6 60.45 cM1.00infobox
Neurotrophin-3Bgeepopliteal artery1.00infobox
Neurotrophin-3Bgeetibial arteries1.00infobox
Neurotrophin-3Bgeeright coronary artery1.00infobox
Neurotrophin-3Bgeeascending aorta1.00infobox
Neurotrophin-3Bgeeleft coronary artery1.00infobox
Neurotrophin-3BgeeDescending thoracic aorta1.00infobox
Neurotrophin-3Bgeeright ovary1.00infobox
Neurotrophin-3Bgeeleft ovary1.00infobox
Neurotrophin-3Bgeetesticle1.00infobox
Neurotrophin-3Bgeesaphenous vein1.00infobox
Neurotrophin-3Bgeeexternal naris1.00infobox
Neurotrophin-3Bgeeciliary body1.00infobox
Neurotrophin-3Bgeeiris1.00infobox
Neurotrophin-3Bgeecorneal stroma1.00infobox
Neurotrophin-3Bgeeconjunctival fornix1.00infobox
Neurotrophin-3Bgeemaxillary prominence1.00infobox
Neurotrophin-3Bgeesubstantia nigra1.00infobox
Neurotrophin-3Bgeepineal gland1.00infobox
Neurotrophin-3Bgeemedullary collecting duct1.00infobox
Neurotrophin-3BioGPSMore reference expression data1.00infobox
Neurotrophin-3Chr.Chromosome 12 (human)1.00infobox
Neurotrophin-3Chr.Chromosome 6 (mouse)1.00infobox
Neurotrophin-3DatabasesNCBI: entry; OMA: entry1.00infobox
Neurotrophin-3End5,521,536 bp1.00infobox
Neurotrophin-3End126,143,873 bp1.00infobox
Neurotrophin-3EnsemblENSG000001856521.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Neurotrophin-3 bring nearby vocabulary together. In this analysis, examples include Signaling, Tyrosine and Trk. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Ntf3
    • Chromosome
    • Human
    • Protein
    • Bp
    • Chr
    • Mouse
    • Band
    • Nerve
    • Neurotrophin
    • Factor
  • neurotrophic factor
    • Growth
    • Ngf
    • Nerve
    • Bdnf
    • Brain
    • Factor
    • Neurotrophic
    • Binds
    • Protein
    • Nt-3
    • Peripheral
    • Receptor
  • growth factor
    • Growth
    • Nerve
    • Brain
    • Neurotrophic
    • Ngf
    • Binds
    • Protein
    • Nt-3
    • Bdnf
    • Peripheral
    • Receptor
    • Activity
  • neurons
    • Peripheral
    • Tyrosine
    • Kinase
    • Protein
    • Neurotrophin
    • Receptor
    • Mouse
    • Binding
    • Brain
    • Cell
    • Location
    • Ntf3
  • nerve growth factor
    • Growth
    • Nerve
    • Brain
    • Neurotrophic
    • Ngf
    • Bdnf
    • Binds
    • Protein
    • Nt-3
    • Also
    • Peripheral
    • Receptor
  • stem cells
    • Neurotrophin
    • Trk
    • Receptors
    • Lngfr
    • Factor
    • Growth
    • Receptor
    • Mouse
    • Peripheral
    • Location
    • Ntf3
    • Signaling
  • receptor tyrosine kinase
    • Kinase
    • Tyrosine
    • Receptor
    • Cell
    • Signaling
    • Neurons
    • Trkc
    • Neurotrophin
    • Mouse
    • Peripheral
    • Receptors
    • Binds
  • bdnf
    • Brain
    • Neurotrophic
    • Ngf
    • Nerve
    • Factor
    • Growth
    • Also
    • Binds
    • Trkb
    • Trkc
    • Nt-3

Connections between topic areas Semantic bridges

For Neurotrophin-3, one of the stronger structural bridges in this analysis connects Neurotrophin-3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Neurotrophin-3Overview · splits 18 ⟂ 11
Neurotrophin-3Mechanism of action · splits 20 ⟂ 9
Neurotrophin-3Function · splits 21 ⟂ 8

Map overview Semantic statistics

Neurotrophin-3

Nodes29
Edges28
Triples102
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around Neurotrophin-3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Mechanism of action, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Neurotrophin-3 · EN edition · Analysis: TopicsToTalkAbout

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