Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Entrectinib

Entrectinib, sold under the brand name Rozlytrek, is an anti-cancer medication used to treat ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. It is a selective tyrosine kinase inhibitor (TKI), of the tropomyosin receptor kinases (TRK) A, B and C, C-ros oncogene 1 (ROS1) and anaplastic lymphoma kinase (ALK).

History, Community, Culture & Applications

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Entrectinib. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EX14 (WHO)
CAS Number
1108743-60-7
ChEBI
CHEBI:195558
ChEMBL
ChEMBL1983268

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Medical uses

History

Mechanism of action

Clinical development

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Entrectinib

Nodes53
Edges52
Triples90
Avg. degree1.96
Density0.037736
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Entrectinib

Top relations

related to history · 30
Entrectinib → ALK-positive, Asia/Pacific, Drug Administration, EU, EudraCT, Europe, FDA, FDA-approved, Food, Health, In, In June, It, Japanese Ministry, Labour, MHLW, NCT02097810, NCT02568267, NCT02650401, NSCLC
related to Clinical development · 11
Entrectinib → AACR American Association, April, Cancer Research Conference, Examples, II, Interim, NSCLC, NTRK, NTRK/ROS1/ALK, STARTRK-2, The
related to Economics · 6
Entrectinib → December, Ignyta, Ignyta Pharmaceuticals, Investigations, On, Roche
Legal status · 5
Entrectinib → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Medical uses · 5
Entrectinib → In, It, NTRK, ROS1-positive, US
related to External links · 3
Entrectinib → National Cancer Institute, NCI Drug Dictionary, September
has effect · 2
Entrectinib → QT, The
related to Names · 2
Entrectinib → INN, International
3D model (JSmol) · 1
Entrectinib → Interactive image
AHFS/Drugs.com · 1
Entrectinib → Monograph

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer ros1 kinase ntrk tyrosine solid cell drug tumors inhibitor alk approved treatment lung receptor side effects nsclc patients gene

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Entrectinib3D model (JSmol)Interactive image1.00infobox
EntrectinibAHFS/Drugs.comMonograph1.00infobox
EntrectinibATC codeL01EX14 (WHO)1.00infobox
EntrectinibCAS Number1108743-60-71.00infobox
EntrectinibChEBICHEBI:1955581.00infobox
EntrectinibChEMBLChEMBL19832681.00infobox
EntrectinibChemSpider248085891.00infobox
EntrectinibCompTox Dashboard (EPA)DTXSID1010264501.00infobox
EntrectinibDrug classAntineoplastic agent1.00infobox
EntrectinibDrugBankDB119861.00infobox
EntrectinibFormulaC31H34F2N6O21.00infobox
EntrectinibKEGGD109261.00infobox
EntrectinibLegal statusAU: S4 (Prescription only)1.00infobox
EntrectinibLegal statusCA: ℞-only1.00infobox
EntrectinibLegal statusUK: POM (Prescription only)1.00infobox
EntrectinibLegal statusUS: ℞-only1.00infobox
EntrectinibLegal statusEU: Rx-only1.00infobox
EntrectinibLicense dataUS DailyMed: Entrectinib1.00infobox
EntrectinibMedlinePlusa6190491.00infobox
EntrectinibMolar mass560.650 g·mol−11.00infobox
EntrectinibOther namesRXDX-101, NMS-E6281.00infobox
EntrectinibPregnancy categoryAU: D1.00infobox
EntrectinibPubChem CID251410921.00infobox
EntrectinibPubChem SID3478283071.00infobox
EntrectinibRoutes of administrationBy mouth1.00infobox
EntrectinibTrade namesRozlytrek1.00infobox
EntrectinibUNIIL5ORF0AN1I1.00infobox
Entrectinibis aselective tyrosine kinase inhibitor with specificity0.90text

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.