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Entrectinib: History, Community, Culture & Applications

Entrectinib, sold under the brand name Rozlytrek, is an anti-cancer medication used to treat ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. It is a selective tyrosine kinase inhibitor (TKI), of the tropomyosin receptor kinases (TRK) A, B and C, C-ros oncogene 1 (ROS1) and anaplastic lymphoma kinase (ALK).

Language: English [EN]
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Entrectinib topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Entrectinib.

Related topics
46
Source areas
6
Connected nodes
52
Extracted relationships
90
Concept neighborhoods
21
Bridge connections
52

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 14 topics
Clinical development · 13 topics
History · 11 topics
Mechanism of action · 5 topics
Society and culture · 2 topics
Medical uses · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EX14 (WHO)
CAS Number
1108743-60-7
ChEBI
CHEBI:195558
ChEMBL
ChEMBL1983268

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

History

Mechanism of action

Clinical development

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Entrectinib connects Entity context

The extracted context around Entrectinib shows recurring relationship patterns in the source. For example, Entrectinib → ALK-positive, Asia/Pacific, Drug Administration, EU, EudraCT, Europe, FDA, FDA-approved, Food, Health, In, In June, It, Japanese Ministry, Labour, MHLW, NCT02097810, NCT02568267, NCT02650401, NSCLC Another extracted example is Entrectinib → AACR American Association, April, Cancer Research Conference, Examples, II, Interim, NSCLC, NTRK, NTRK/ROS1/ALK, STARTRK-2, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Entrectinib

Top relations

related to history · 30
Entrectinib → ALK-positive, Asia/Pacific, Drug Administration, EU, EudraCT, Europe, FDA, FDA-approved, Food, Health, In, In June, It, Japanese Ministry, Labour, MHLW, NCT02097810, NCT02568267, NCT02650401, NSCLC
related to Clinical development · 11
Entrectinib → AACR American Association, April, Cancer Research Conference, Examples, II, Interim, NSCLC, NTRK, NTRK/ROS1/ALK, STARTRK-2, The
related to Economics · 6
Entrectinib → December, Ignyta, Ignyta Pharmaceuticals, Investigations, On, Roche
Legal status · 5
Entrectinib → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Medical uses · 5
Entrectinib → In, It, NTRK, ROS1-positive, US
related to External links · 3
Entrectinib → National Cancer Institute, NCI Drug Dictionary, September
has effect · 2
Entrectinib → QT, The
related to Names · 2
Entrectinib → INN, International
3D model (JSmol) · 1
Entrectinib → Interactive image
AHFS/Drugs.com · 1
Entrectinib → Monograph

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer ros1 kinase ntrk tyrosine solid cell drug tumors inhibitor alk approved treatment lung receptor side effects nsclc patients gene

Entrectinib relationships Subject–Predicate–Object triples

TTTA extracted 90 structured relationships around Entrectinib. Examples in this analysis include Entrectinib → 3D model (JSmol) → Interactive image and Entrectinib → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Entrectinib3D model (JSmol)Interactive image1.00infobox
EntrectinibAHFS/Drugs.comMonograph1.00infobox
EntrectinibATC codeL01EX14 (WHO)1.00infobox
EntrectinibCAS Number1108743-60-71.00infobox
EntrectinibChEBICHEBI:1955581.00infobox
EntrectinibChEMBLChEMBL19832681.00infobox
EntrectinibChemSpider248085891.00infobox
EntrectinibCompTox Dashboard (EPA)DTXSID1010264501.00infobox
EntrectinibDrug classAntineoplastic agent1.00infobox
EntrectinibDrugBankDB119861.00infobox
EntrectinibFormulaC31H34F2N6O21.00infobox
EntrectinibKEGGD109261.00infobox
EntrectinibLegal statusAU: S4 (Prescription only)1.00infobox
EntrectinibLegal statusCA: ℞-only1.00infobox
EntrectinibLegal statusUK: POM (Prescription only)1.00infobox
EntrectinibLegal statusUS: ℞-only1.00infobox
EntrectinibLegal statusEU: Rx-only1.00infobox
EntrectinibLicense dataUS DailyMed: Entrectinib1.00infobox
EntrectinibMedlinePlusa6190491.00infobox
EntrectinibMolar mass560.650 g·mol−11.00infobox
EntrectinibOther namesRXDX-101, NMS-E6281.00infobox
EntrectinibPregnancy categoryAU: D1.00infobox
EntrectinibPubChem CID251410921.00infobox
EntrectinibPubChem SID3478283071.00infobox
EntrectinibRoutes of administrationBy mouth1.00infobox
EntrectinibTrade namesRozlytrek1.00infobox
EntrectinibUNIIL5ORF0AN1I1.00infobox
Entrectinibis aselective tyrosine kinase inhibitor with specificity0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Entrectinib bring nearby vocabulary together. In this analysis, examples include Cancer, Solid and Ntrk. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Entrectinib
    • Cancer
    • Solid
    • Ntrk
    • Non-small
    • Lung
    • Cell
    • Inhibitor
    • Tumors
    • Drug
    • Clinical
    • Metastatic
    • Name
  • entrectinib
    • Cancer
    • Solid
    • Ntrk
    • Non-small
    • Lung
    • Cell
    • Inhibitor
    • Tumors
    • Drug
    • Clinical
    • Metastatic
    • Name
  • non-small cell lung cancer
    • Lung
    • Non-small
    • Nsclc
    • Cancer
    • Cell
    • Mcrc
    • Metastatic
    • Ros1-positive
    • Ntrk
    • Treatment
    • Gene
    • Entrectinib
  • anaplastic lymphoma kinase
    • Tyrosine
    • Receptor
    • Include
    • Inhibitor
    • Kinases
    • Alk
    • Fusion
    • Gene
    • Lymphoma
    • Mcrc
    • Medical
    • Ros1
  • metastatic colorectal cancer
    • Lung
    • Cell
    • Non-small
    • Nsclc
    • Ntrk
    • Treatment
    • Mcrc
    • Entrectinib
    • Use
    • Solid
    • Approved
    • Tumors
  • salivary gland cancer
    • Lung
    • Cell
    • Non-small
    • Nsclc
    • Ntrk
    • Treatment
    • Mcrc
    • Entrectinib
    • Use
    • Approved
    • Tumors
    • Solid
  • thyroid cancer
    • Lung
    • Cell
    • Non-small
    • Nsclc
    • Ntrk
    • Treatment
    • Mcrc
    • Entrectinib
    • Use
    • Approved
    • Tumors
    • Solid
  • tyrosine kinase inhibitor
    • Tyrosine
    • Receptor
    • Trk
    • Inhibitor
    • Kinase
    • Kinases
    • Fusion
    • Gene
    • Alk
    • Ros1
    • Lymphoma
    • Treatment

Connections between topic areas Semantic bridges

For Entrectinib, one of the stronger structural bridges in this analysis connects Entrectinib with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Entrectinib — Overview · splits 38 ⟂ 15
Entrectinib — Clinical development · splits 39 ⟂ 14
Entrectinib — History · splits 41 ⟂ 12
Entrectinib — Mechanism of action · splits 47 ⟂ 6
Entrectinib — Society and culture · splits 50 ⟂ 3

Map overview Semantic statistics

Entrectinib

Nodes53
Edges52
Triples90
Avg. degree1.96
Density0.037736
Components1

Source & methodology

TTTA analyzes the structure around Entrectinib to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Entrectinib · EN edition · Analysis: TopicsToTalkAbout

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