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Explore the main themes, entities and connections around Protein inhibitor of activated STAT. Start with the topic map, then use the sections below for research and deeper semantic analysis.
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Structure
Potential applications
Function
Overview
Key facts & relationships
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Topics to explore
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.Browse the full topic structure. Each item opens a new analysis centered on that subject.
Overview
- Protein
- Regulates transcription Transcriptional regulation
- Mammals
- Transcriptional co-regulators Transcription coregulator
- Activate Activator (genetics)
- Repress Repressor
- Transcription Transcription (genetics)
- Transcription factors
- STAT STAT protein
- NF-κB
- P73
- P53
- Family Protein family
- Genes
- PIAS1
- PIAS2
- PIAS3
- PIAS4
- Isoforms
- Homologues Homology (biology)
- Eukaryotes
- Drosophila melanogaster
- Zebrafish
- Yeast Saccharomyces cerevisiae
- Conserved Conserved sequence
- Domain Protein domain
- Motif Structural motif
- SUMO SUMO protein
- Ligases Ligase
- SUMOylation
Discovery
- Yeast two-hybrid assay Two-hybrid screening
Types of PIAS proteins
Function
- Transcription factor
- Protein–protein interaction
- Nucleus Cell nucleus
- Cell Cell (biology)
- DNA repair
- UV light
- Chemicals
- Ionizing radiation
- JAK/STAT signaling pathway JAK-STAT signaling pathway
- Tyrosine phosphorylation
- Methylated Methylation
- STAT1
- STAT3
- Cytokine
- IL-6 Interleukin 6
- TNF Tumor necrosis factor alpha
- LPS endotoxin Lipopolysaccharide
Structure
- X-ray crystallography
- Structural Genomics Consortium
- N-terminal
- Scaffold attachment factor Matrix attachment region
- Acinus
- Pro Proline
- Ile Isoleucine
- Asn Asparagine
- Threonine
- RING RING finger domain
- Finger Zinc finger
- Zinc
- Serine
- C-terminal region C-terminus
- Alpha helices
- Chromatin
- Adenine
- Thymine
- Matrix-attachment regions S/MAR
- Nuclear matrix
- Amino acid motif Amino acid motifs
- Leucine
- Nuclear receptors
- Ligand
- Cytosol
- Histidine
- Cysteine
Potential applications
Advanced semantic analysis
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Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.Protein inhibitor of activated STAT
How this topic connects Entity context
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Important terminology Word statistics
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Important terminology
pias proteins protein pias3 transcription pias1 motif family known domain stat piasy found cancer also e3 sumo-protein important pinit homologues
Entity relationships Subject–Predicate–Object triples
Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Drosophila | instance of | and PIAS4 survived for a longer period of time in a retrospective study of advanced gastric cancer patients.Continuous activation of the JAK-STAT pathway can cause cancer in hum… | 0.80 | text |
Related concept clusters Concept neighborhoods
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Connections between topic areas Semantic bridges
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