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Protein inhibitor of activated STAT

Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates transcription in mammals. PIAS proteins act as transcriptional co-regulators with at least 60 different proteins in order to either activate or repress transcription. The transcription factors STAT, NF-κB, p73, and p53 are among the many…

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Protein inhibitor of activated STAT

Nodes101
Edges100
Triples1
Avg. degree1.98
Density0.019802
Components1

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pias proteins protein pias3 transcription pias1 motif family known domain stat piasy found cancer also e3 sumo-protein important pinit homologues

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SubjectPredicateObjectConfidenceSrc
Drosophilainstance ofand PIAS4 survived for a longer period of time in a retrospective study of advanced gastric cancer patients.Continuous activation of the JAK-STAT pathway can cause cancer in hum…0.80text

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