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PDPN: Tissues distribution, Activation of CLEC-2 & Function and clinical significance

PDPN, i.e., podoplanin, is a small glycoprotein located on the surface membranes of various cell types. While termed PDPN in humans, it is often named: a) OTS-8, gp38, aggrus, antigen PA2.26, or RANDAM-2 (i.e., retinoic acid-induced neuronal differentiated-associated molecule-2) in mice; b) T1α protein or E11 antigen in rats; c) aggrus or gp40 in…

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PDPN topic overview

The analysis highlights Tissues distribution, Activation of CLEC-2 and Function and clinical significance as prominent areas in the source structure around PDPN.

Related topics
266
Source areas
5
Connected nodes
271
Extracted relationships
282
Related term clusters
55
Bridge connections
271

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function and clinical significance · 170 topics
Tissues distribution · 41 topics
Activation of CLEC-2 · 34 topics
Structure · 12 topics
Overview · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, D2-40
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WSR, 4YO0
Band
1p36.21 · 4|4 E1
Bgee
tibia · gonad · cartilage tissue · ventricular zone · germinal epithelium
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

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Explore different angles and find fresh ideas to shape your next piece of content.

PDPN
7Glycoprotein · Cell membrane · Gene
23Platelets · Megakaryocytes · Blood clot
11Mucin · O-linked glycosylation · Single-pass membrane protein
28Physiological · Pathological · Cerebellum
30CLEC1B · PDPN · Pattern recognition receptors

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Tissues distribution

Structure

Activation of CLEC-2

Function and clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How PDPN connects Entity context

The extracted context around PDPN shows recurring relationship patterns in the source. For example, PDPN → actin-mediated cell contraction, amino acid transmembrane transport, amino acid transmembrane transporter activity, amino acid transport, apical plasma membrane, basolateral plasma membrane, cell junction, cell morphogenesis, cell projection, chaperone binding, chemokine binding, cytoplasm, cytoplasmic vesicle, cytosol, filopodium, filopodium membrane, folic acid transmembrane transporter activity, folic acid transport, integral component of membrane, integral component of plasma membrane Another extracted example is PDPN → A13, C-type, Classification, CLEC-2, CLEC1B, CLEC2, CLEC2B, CLEC7A, HIV, Immunoreceptor, Immunoreceptor Tyrosine-based Activation Motif, ITAM, PLAG-3/PLAG-4, Polygonaceae, PRO1384, QDED721, S100, S100A13, Signal, SYK. Use these groups to spot repeated connection types before inspecting the individual relationships.

PDPN

Top relations

Gene ontology · 53
PDPN → actin-mediated cell contraction, amino acid transmembrane transport, amino acid transmembrane transporter activity, amino acid transport, apical plasma membrane, basolateral plasma membrane, cell junction, cell morphogenesis, cell projection, chaperone binding, chemokine binding, cytoplasm, cytoplasmic vesicle, cytosol, filopodium, filopodium membrane, folic acid transmembrane transporter activity, folic acid transport, integral component of membrane, integral component of plasma membrane
related to Activation of CLEC-2 · 22
PDPN → A13, C-type, Classification, CLEC-2, CLEC1B, CLEC2, CLEC2B, CLEC7A, HIV, Immunoreceptor, Immunoreceptor Tyrosine-based Activation Motif, ITAM, PLAG-3/PLAG-4, Polygonaceae, PRO1384, QDED721, S100, S100A13, Signal, SYK
related to Inhibitors · 19
PDPN → CAFs, CLEC-2, Following, IRDye700DX, IX, MOC, NIR-PIT, NZ-1, PDPN's, PDPN-expressing, PDPN-expressing CAFs, PDPN-expressing MOC, PDPN-induced, PDPN-positive, PDPN-promoted, SZ-168, This PDPN-targeted NIR-PIT, Three, Various
Bgee · 18
PDPN → blastocyst, cartilage tissue, gallbladder, ganglionic eminence, gastric mucosa, germinal epithelium, gonad, lens, lung, ovary, primary oocyte, retinal pigment epithelium, secondary oocyte, tibia, urinary bladder, ventricular zone, yolk sac, zygote
RNA expression pattern · 18
PDPN → blastocyst, cartilage tissue, gallbladder, ganglionic eminence, gastric mucosa, germinal epithelium, gonad, lens, lung, ovary, primary oocyte, retinal pigment epithelium, secondary oocyte, tibia, urinary bladder, ventricular zone, yolk sac, zygote
related to Development of blood vessels, lymphatic vessels, and the heart · 16
PDPN → CLEC-2, CLEC-2's, CLEC-2-deficient, Finally, Mouse, PDPN's, PDPN-bound CLEC-2, PDPN-deficient, Pericytes, PLCG2, PLCγ2, SLP-76, Studies, Syk, TGF-β, Treating
related to Cancer-associated venous thromboembolisms · 14
PDPN → Armand Trousseau, B16, B16F10, Cancer-associated, Cancers, Chinese, CLEC-2, Furthermore, Gioioso, PDPN-expressing, PDPN-expressing C8161, Preclinical, SZ-168, Trousseau
related to Development of the lung · 11
PDPN → ACTA2, AEV, Clec-2, Embryos, LECs, Mice, Mouse, PCM, SMA, Wilms, Wt1
related to Structure · 9
PDPN → C-terminal, Human PDPN, Human PDPN's, N-terminal, O-linked, PDPN-expressing, PDPNs, PLAG, Type
related to Function and clinical significance · 8
PDPN → CLEC-2, Finally, PDPN's, PDPN-expressing, PDPN-negative, PDPN-positive, Similar, The PLAG-3/PLAG-4

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

clec-2 cells studies levels cancer patients mice blood human lung expressed platelets cvtes cell gene activation lymphatic study cancers expression

PDPN relationships Subject–Predicate–Object triples

TTTA extracted 282 structured relationships around PDPN. Examples in this analysis include PDPN → Aliases → PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, D2-40 and PDPN → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WSR, 4YO0. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PDPNAliasesPDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, D2-401.00infobox
PDPNAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WSR, 4YO01.00infobox
PDPNBand1p36.211.00infobox
PDPNBand4|4 E11.00infobox
PDPNBgeetibia1.00infobox
PDPNBgeegonad1.00infobox
PDPNBgeecartilage tissue1.00infobox
PDPNBgeeventricular zone1.00infobox
PDPNBgeegerminal epithelium1.00infobox
PDPNBgeeretinal pigment epithelium1.00infobox
PDPNBgeesecondary oocyte1.00infobox
PDPNBgeeganglionic eminence1.00infobox
PDPNBgeegallbladder1.00infobox
PDPNBgeegastric mucosa1.00infobox
PDPNBgeeyolk sac1.00infobox
PDPNBgeelung1.00infobox
PDPNBgeeprimary oocyte1.00infobox
PDPNBgeezygote1.00infobox
PDPNBgeeblastocyst1.00infobox
PDPNBgeeurinary bladder1.00infobox
PDPNBgeeovary1.00infobox
PDPNBgeelens1.00infobox
PDPNBioGPSMore reference expression data1.00infobox
PDPNChr.Chromosome 1 (human)1.00infobox
PDPNChr.Chromosome 4 (mouse)1.00infobox
PDPNDatabasesNCBI: entry; OMA: entry1.00infobox
PDPNEnd13,617,957 bp1.00infobox
PDPNEnd143,026,134 bp1.00infobox
PDPNEnsemblENSG000001624931.00infobox
PDPNEntrez106301.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around PDPN bring nearby vocabulary together. In this analysis, examples include Cells, Clec-2 and Studies. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PDPN
    • Cells
    • Clec-2
    • Studies
    • Levels
    • Expressed
    • Expression
    • Cell
    • Cancer
    • Lymphatic
    • Blood
    • Patients
    • Activation
  • pdpn
    • Cells
    • Clec-2
    • Studies
    • Levels
    • Expressed
    • Expression
    • Cell
    • Cancer
    • Lymphatic
    • Blood
    • Patients
    • Activation
  • gene
    • Human
    • Expression
    • Platelet
    • Development
    • Lung
    • Glycoprotein
    • Activation
    • Study
    • Pdpn
    • Caused
    • Kidney
    • Protein
  • gene nomenclature
    • Human
    • Expression
    • Platelet
    • Development
    • Lung
    • Glycoprotein
    • Activation
    • Study
    • Pdpn
    • Caused
    • Kidney
    • Protein
  • type i alveolar cells
    • Pdpn
    • Expressed
    • Lymphatic
    • Vessels
    • Mouse
    • Mice
    • Clec-2
    • Studies
    • Skin
    • Levels
    • Developing
    • Protein
  • endothelial cells
    • Pdpn
    • Expressed
    • Lymphatic
    • Vessels
    • Mouse
    • Mice
    • Clec-2
    • Studies
    • Skin
    • Levels
    • Developing
    • Protein
  • reticular cells
    • Pdpn
    • Expressed
    • Lymphatic
    • Vessels
    • Mouse
    • Mice
    • Clec-2
    • Studies
    • Skin
    • Levels
    • Developing
    • Protein
  • ependymal cells
    • Pdpn
    • Expressed
    • Lymphatic
    • Vessels
    • Mouse
    • Mice
    • Clec-2
    • Studies
    • Skin
    • Levels
    • Developing
    • Protein

Connections between topic areas Semantic bridges

For PDPN, one of the stronger structural bridges in this analysis connects PDPN with Function and clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PDPN — Function and clinical significance · splits 101 ⟂ 171
PDPN — Tissues distribution · splits 230 ⟂ 42
PDPN — Activation of CLEC-2 · splits 237 ⟂ 35
PDPN — Structure · splits 259 ⟂ 13
PDPN — Overview · splits 262 ⟂ 10

Map overview Semantic statistics

PDPN

Nodes272
Edges271
Triples282
Avg. degree1.99
Density0.007353
Components1

Source & methodology

TTTA analyzes the structure around PDPN to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Tissues distribution, Activation of CLEC-2 & Function and clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PDPN · EN edition · Analysis: TopicsToTalkAbout

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