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PDPN

PDPN, i.e., podoplanin, is a small glycoprotein located on the surface membranes of various cell types. While termed PDPN in humans, it is often named: a) OTS-8, gp38, aggrus, antigen PA2.26, or RANDAM-2 (i.e., retinoic acid-induced neuronal differentiated-associated molecule-2) in mice; b) T1α protein or E11 antigen in rats; c) aggrus or gp40 in…

Tissues distribution, Activation of CLEC-2 & Function and clinical significance

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Aliases
PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, D2-40
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WSR, 4YO0
Band
1p36.21 · 4|4 E1
Bgee
tibia · gonad · cartilage tissue · ventricular zone · germinal epithelium
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

Topics to explore

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Overview

Tissues distribution

Structure

Activation of CLEC-2

Function and clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

PDPN

Nodes275
Edges274
Triples334
Avg. degree1.99
Density0.007273
Components1

How this topic connects Entity context

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PDPN

Top relations

Gene ontology · 53
PDPN → actin-mediated cell contraction, amino acid transmembrane transport, amino acid transmembrane transporter activity, amino acid transport, apical plasma membrane, basolateral plasma membrane, cell junction, cell morphogenesis, cell projection, chaperone binding, chemokine binding, cytoplasm, cytoplasmic vesicle, cytosol, filopodium, filopodium membrane, folic acid transmembrane transporter activity, folic acid transport, integral component of membrane, integral component of plasma membrane
related to Activation of CLEC-2 · 24
PDPN → A13, C-type, Classification, CLEC-2, CLEC1B, CLEC2, CLEC2B, CLEC7A, HIV, Immunoreceptor, Immunoreceptor Tyrosine-based Activation Motif, It, ITAM, PLAG-3/PLAG-4, Polygonaceae, PRO1384, QDED721, S100, S100A13, Signal
related to Inhibitors · 23
PDPN → CAFs, CLEC-2, Following, IRDye700DX, It, IX, MOC, NIR-PIT, NZ-1, PDPN's, PDPN-expressing, PDPN-expressing CAFs, PDPN-expressing MOC, PDPN-induced, PDPN-positive, PDPN-promoted, SZ-168, The, These, This
related to Development of blood vessels, lymphatic vessels, and the heart · 21
PDPN → CLEC-2, CLEC-2's, CLEC-2-deficient, Finally, It, Mouse, Other, PDPN's, PDPN-bound CLEC-2, PDPN-deficient, Pericytes, PLCG2, PLCγ2, SLP-76, Studies, Syk, TGF-β, The, These, This
Bgee · 18
PDPN → blastocyst, cartilage tissue, gallbladder, ganglionic eminence, gastric mucosa, germinal epithelium, gonad, lens, lung, ovary, primary oocyte, retinal pigment epithelium, secondary oocyte, tibia, urinary bladder, ventricular zone, yolk sac, zygote
RNA expression pattern · 18
PDPN → blastocyst, cartilage tissue, gallbladder, ganglionic eminence, gastric mucosa, germinal epithelium, gonad, lens, lung, ovary, primary oocyte, retinal pigment epithelium, secondary oocyte, tibia, urinary bladder, ventricular zone, yolk sac, zygote
related to Cancer-associated venous thromboembolisms · 18
PDPN → Armand Trousseau, As, B16, B16F10, Cancer-associated, Cancers, Chinese, CLEC-2, For, Furthermore, Gioioso, Other, PDPN-expressing, PDPN-expressing C8161, Preclinical, SZ-168, These, Trousseau
related to Development of the lung · 13
PDPN → ACTA2, AEV, Clec-2, Embryos, LECs, Mice, Mouse, PCM, SMA, The, Their, Wilms, Wt1
related to Function and clinical significance · 12
PDPN → CLEC-2, Finally, However, PDPN's, PDPN-expressing, PDPN-negative, PDPN-positive, Similar, The, The PLAG-3/PLAG-4, These, While
related to Kidney function · 11
PDPN → As, CLEC-2, Dahl, Dahl/SS, Munich-Wistar-Frömter, MWF, Studies, The, These, This, Two

Important terminology Word statistics

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Important terminology

clec-2 cells studies levels cancer patients mice blood human lung expressed platelets cvtes cell gene activation lymphatic study cancers expression

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PDPNAliasesPDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, D2-401.00infobox
PDPNAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WSR, 4YO01.00infobox
PDPNBand1p36.211.00infobox
PDPNBand4|4 E11.00infobox
PDPNBgeetibia1.00infobox
PDPNBgeegonad1.00infobox
PDPNBgeecartilage tissue1.00infobox
PDPNBgeeventricular zone1.00infobox
PDPNBgeegerminal epithelium1.00infobox
PDPNBgeeretinal pigment epithelium1.00infobox
PDPNBgeesecondary oocyte1.00infobox
PDPNBgeeganglionic eminence1.00infobox
PDPNBgeegallbladder1.00infobox
PDPNBgeegastric mucosa1.00infobox
PDPNBgeeyolk sac1.00infobox
PDPNBgeelung1.00infobox
PDPNBgeeprimary oocyte1.00infobox
PDPNBgeezygote1.00infobox
PDPNBgeeblastocyst1.00infobox
PDPNBgeeurinary bladder1.00infobox
PDPNBgeeovary1.00infobox
PDPNBgeelens1.00infobox
PDPNBioGPSMore reference expression data1.00infobox
PDPNChr.Chromosome 1 (human)1.00infobox
PDPNChr.Chromosome 4 (mouse)1.00infobox
PDPNDatabasesNCBI: entry; OMA: entry1.00infobox
PDPNEnd13,617,957 bp1.00infobox
PDPNEnd143,026,134 bp1.00infobox
PDPNEnsemblENSG000001624931.00infobox
PDPNEntrez106301.00infobox

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