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Wilms tumor protein: Products, Clinical significance & Experimental models

Wilms tumor protein (WT33) is a protein that in humans is encoded by the WT1 gene on chromosome 11p.

Language: English [EN]
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Wilms tumor protein topic overview

The analysis highlights Products, Clinical significance and Experimental models as prominent areas in the source structure around Wilms tumor protein.

Related topics
86
Source areas
7
Connected nodes
93
Extracted relationships
141
Concept neighborhoods
24
Bridge connections
93

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 35 topics
Experimental models · 22 topics
Function · 9 topics
Interactions · 7 topics
RNA editing · 6 topics
Structure · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
WT1, AEWS-GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor 1, WT1 transcription factor, WT-1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XF7, 2JP9, 2JPA, 2PRT, 3HPJ, 3MYJ, 4R2E, 4R2P, 4R2Q, 4R2R, 4R2S, 4WUU
Band
11p13 · 2 E3|2 55.06 cM
Bgee
germinal epithelium · glomerulus · metanephric glomerulus · parietal pleura · right uterine tube
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Clinical significance

Interactions

RNA editing

Experimental models

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Wilms tumor protein connects Entity context

The extracted context around Wilms tumor protein shows recurring relationship patterns in the source. For example, Wilms tumor protein → adrenal cortex formation, adrenal gland development, branching involved in ureteric bud morphogenesis, C2H2 zinc finger domain binding, camera-type eye development, cardiac muscle cell fate commitment, cellular response to cAMP, cellular response to gonadotropin stimulus, cytoplasm, cytosol, development of the heart, diaphragm development, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded methylated DNA binding, epithelial cell differentiation, germ cell development, glomerular basement membrane development Another extracted example is Wilms tumor protein → adventitia of seminal vesicle, body of uterus, coelomic epithelium, decidua, dorsal mesentery, gastrula, germinal epithelium, glomerulus, Gonadal ridge, left ovary, left uterine tube, mesorchium, metanephric glomerulus, muscle layer of seminal vesicle, myometrium, parietal pleura, right uterine tube, vas deferens. Use these groups to spot repeated connection types before inspecting the individual relationships.

Wilms tumor protein

Top relations

Gene ontology · 71
Wilms tumor protein → adrenal cortex formation, adrenal gland development, branching involved in ureteric bud morphogenesis, C2H2 zinc finger domain binding, camera-type eye development, cardiac muscle cell fate commitment, cellular response to cAMP, cellular response to gonadotropin stimulus, cytoplasm, cytosol, development of the heart, diaphragm development, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded methylated DNA binding, epithelial cell differentiation, germ cell development, glomerular basement membrane development
Bgee · 18
Wilms tumor protein → adventitia of seminal vesicle, body of uterus, coelomic epithelium, decidua, dorsal mesentery, gastrula, germinal epithelium, glomerulus, Gonadal ridge, left ovary, left uterine tube, mesorchium, metanephric glomerulus, muscle layer of seminal vesicle, myometrium, parietal pleura, right uterine tube, vas deferens
RNA expression pattern · 18
Wilms tumor protein → adventitia of seminal vesicle, body of uterus, coelomic epithelium, decidua, dorsal mesentery, gastrula, germinal epithelium, glomerulus, Gonadal ridge, left ovary, left uterine tube, mesorchium, metanephric glomerulus, muscle layer of seminal vesicle, myometrium, parietal pleura, right uterine tube, vas deferens
related to External links · 9
Wilms tumor protein → AniridiaGeneReviews/NIH/NCBI/UW, AniridiaOMIM, GeneReviews/NCBI/NIH/UW, P19544, PDB, PDBe-KB, UniProt, Wilms, Wilms Tumor OverviewOverview
Band · 2
Wilms tumor protein → 11p13, 2 E3|2 55.06 cM
Chr. · 2
Wilms tumor protein → Chromosome 11 (human), Chromosome 2 (mouse)
End · 2
Wilms tumor protein → 105,003,961 bp, 32,435,564 bp
Aliases · 1
Wilms tumor protein → WT1, AEWS-GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor 1, WT1 transcription factor, WT-1
Available structures · 1
Wilms tumor protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XF7, 2JP9, 2JPA, 2PRT, 3HPJ, 3MYJ, 4R2E, 4R2P, 4R2Q, 4R2R, 4R2S, 4WUU
BioGPS · 1
Wilms tumor protein → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

wt1 editing gene protein human bp mouse tumor chromosome wilms chr band expression mice rna well transcription 11 development kidney

Wilms tumor protein relationships Subject–Predicate–Object triples

TTTA extracted 141 structured relationships around Wilms tumor protein. Examples in this analysis include Wilms tumor protein → Aliases → WT1, AEWS-GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor 1, WT1 transcription factor, WT-1 and Wilms tumor protein → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XF7, 2JP9, 2JPA, 2PRT, 3HPJ, 3MYJ, 4R2E, 4R2P, 4R2Q, 4R2R, 4R2S, 4WUU. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Wilms tumor proteinAliasesWT1, AEWS-GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor 1, WT1 transcription factor, WT-11.00infobox
Wilms tumor proteinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XF7, 2JP9, 2JPA, 2PRT, 3HPJ, 3MYJ, 4R2E, 4R2P, 4R2Q, 4R2R, 4R2S, 4WUU1.00infobox
Wilms tumor proteinBand11p131.00infobox
Wilms tumor proteinBand2 E3|2 55.06 cM1.00infobox
Wilms tumor proteinBgeegerminal epithelium1.00infobox
Wilms tumor proteinBgeeglomerulus1.00infobox
Wilms tumor proteinBgeemetanephric glomerulus1.00infobox
Wilms tumor proteinBgeeparietal pleura1.00infobox
Wilms tumor proteinBgeeright uterine tube1.00infobox
Wilms tumor proteinBgeeleft uterine tube1.00infobox
Wilms tumor proteinBgeebody of uterus1.00infobox
Wilms tumor proteinBgeedecidua1.00infobox
Wilms tumor proteinBgeemyometrium1.00infobox
Wilms tumor proteinBgeeleft ovary1.00infobox
Wilms tumor proteinBgeegastrula1.00infobox
Wilms tumor proteinBgeeGonadal ridge1.00infobox
Wilms tumor proteinBgeedorsal mesentery1.00infobox
Wilms tumor proteinBgeeadventitia of seminal vesicle1.00infobox
Wilms tumor proteinBgeemesorchium1.00infobox
Wilms tumor proteinBgeecoelomic epithelium1.00infobox
Wilms tumor proteinBgeevas deferens1.00infobox
Wilms tumor proteinBgeemuscle layer of seminal vesicle1.00infobox
Wilms tumor proteinBioGPSMore reference expression data1.00infobox
Wilms tumor proteinChr.Chromosome 11 (human)1.00infobox
Wilms tumor proteinChr.Chromosome 2 (mouse)1.00infobox
Wilms tumor proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Wilms tumor proteinEnd32,435,564 bp1.00infobox
Wilms tumor proteinEnd105,003,961 bp1.00infobox
Wilms tumor proteinEnsemblENSG000001849371.00infobox
Wilms tumor proteinEntrez74901.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Wilms tumor protein bring nearby vocabulary together. In this analysis, examples include Wilms, Growth and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Wilms tumor protein
    • Wilms
    • Growth
    • Chromosome
    • Protein
    • Tumor
    • Zinc
    • Cell
    • Expression
    • Gene
    • Mouse
    • Wt1
    • Clinical
  • wilms tumor protein
    • Wilms
    • Growth
    • Gene
    • Chromosome
    • Wt1
    • Protein
    • Tumor
    • Found
    • Zinc
    • Cell
    • Transcription
    • Rna
  • protein
    • Growth
    • Gene
    • Wt1
    • Tumor
    • Zinc
    • Cell
    • Transcription
    • Chromosome
    • Rna
    • Expression
    • Wilms
    • Mouse
  • gene
    • Chromosome
    • Location
    • Bp
    • Chr
    • Found
    • Protein
    • Rna
    • Human
    • Zinc
    • Editing
    • Factor
    • Function
  • transcription factor
    • Rna
    • Domain
    • Function
    • Human
    • Location
    • Mrna
    • Acid
    • Growth
    • Transcription
    • Bp
    • Chr
    • Zinc
  • steroidogenic factor 1
    • Rna
    • Function
    • Human
    • Location
    • Mrna
    • Transcription
    • Bp
    • Chr
    • Domain
    • Zinc
    • Acid
    • Cell
  • rna editing
    • Acid
    • Mrna
    • Transcription
    • Rna
    • Gene
    • Domain
    • Zinc
    • Cell
    • Growth
    • Band
    • Factor
    • Humans
  • function
    • Transcription
    • Domain
    • Acid
    • Factor
    • Location
    • Bp
    • Chr
    • Rna
    • Human
    • Zinc
    • Cell
    • Growth

Connections between topic areas Semantic bridges

For Wilms tumor protein, one of the stronger structural bridges in this analysis connects Wilms tumor protein with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Wilms tumor proteinClinical significance · splits 58 ⟂ 36
Wilms tumor proteinExperimental models · splits 71 ⟂ 23
Wilms tumor proteinFunction · splits 84 ⟂ 10
Wilms tumor proteinInteractions · splits 86 ⟂ 8
Wilms tumor proteinRNA editing · splits 87 ⟂ 7
Wilms tumor proteinStructure · splits 88 ⟂ 6
Wilms tumor proteinOverview · splits 91 ⟂ 3

Map overview Semantic statistics

Wilms tumor protein

Nodes94
Edges93
Triples141
Avg. degree1.98
Density0.021277
Components1

Source & methodology

TTTA analyzes the structure around Wilms tumor protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Clinical significance & Experimental models, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Wilms tumor protein · EN edition · Analysis: TopicsToTalkAbout

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