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Janus kinase 2

Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain…

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2.7.10.2
Aliases
JAK2, JTK10, THCYT3, Janus kinase 2, MAX2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD,…
Band
9p24.1 · 19 C1|19 23.73 cM
Bgee
Achilles tendon · monocyte · popliteal artery · tibial arteries · glutes
BioGPS
n/a

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Janus kinase 2

Nodes64
Edges63
Triples201
Avg. degree1.97
Density0.03125
Components1

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Janus kinase 2

Top relations

Gene ontology · 131
Janus kinase 2 → acetylcholine receptor binding, actin filament polymerization, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, activation of Janus kinase activity, adaptive immune response, apoptotic process, ATP binding, axon regeneration, blood coagulation, caveola, cell differentiation, cell migration, chromatin organization, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, endomembrane system, endosome lumen
Bgee · 20
Janus kinase 2 → Achilles tendon, ascending aorta, blood, Descending thoracic aorta, fossa, glutes, jejunum, left coronary artery, mesenteric lymph nodes, monocyte, Paneth cell, popliteal artery, primary oocyte, Rostral migratory stream, secondary oocyte, sural nerve, tibia, tibial arteries, uterus, zygote
RNA expression pattern · 20
Janus kinase 2 → Achilles tendon, ascending aorta, blood, Descending thoracic aorta, fossa, glutes, jejunum, left coronary artery, mesenteric lymph nodes, monocyte, Paneth cell, popliteal artery, primary oocyte, Rostral migratory stream, secondary oocyte, sural nerve, tibia, tibial arteries, uterus, zygote
Band · 2
Janus kinase 2 → 19 C1|19 23.73 cM, 9p24.1
Chr. · 2
Janus kinase 2 → Chromosome 19 (mouse), Chromosome 9 (human)
End · 2
Janus kinase 2 → 29,290,480 bp, 5,129,948 bp
related to Interactions · 2
Janus kinase 2 → DNAJA3EGFREPORFYNGrb2GHRIRS1IL12RB2IL5RAPIK3R1PPP2R4PTK2PTPN11PTPN6PRMT5SH2B1SHC1SOCS3STAT5ASTAT5BSTAMSOCS1TECTNFRSF1AVAV1YES1, Janus
2.7.10.2 · 1
Janus kinase 2 → ↗
Aliases · 1
Janus kinase 2 → JAK2, JTK10, THCYT3, Janus kinase 2, MAX2
Available structures · 1
Janus kinase 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD,…

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Important terminology

kinase jak2 janus bp chr human band chromosome domains gene tyrosine receptor location orthologs family homology jh sh2 mouse signaling

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Janus kinase 22.7.10.21.00infobox
Janus kinase 2AliasesJAK2, JTK10, THCYT3, Janus kinase 2, MAX21.00infobox
Janus kinase 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD,…1.00infobox
Janus kinase 2Band9p24.11.00infobox
Janus kinase 2Band19 C1|19 23.73 cM1.00infobox
Janus kinase 2BgeeAchilles tendon1.00infobox
Janus kinase 2Bgeemonocyte1.00infobox
Janus kinase 2Bgeepopliteal artery1.00infobox
Janus kinase 2Bgeetibial arteries1.00infobox
Janus kinase 2Bgeeglutes1.00infobox
Janus kinase 2BgeeDescending thoracic aorta1.00infobox
Janus kinase 2Bgeeascending aorta1.00infobox
Janus kinase 2Bgeesural nerve1.00infobox
Janus kinase 2Bgeetibia1.00infobox
Janus kinase 2Bgeeleft coronary artery1.00infobox
Janus kinase 2Bgeezygote1.00infobox
Janus kinase 2Bgeesecondary oocyte1.00infobox
Janus kinase 2Bgeeprimary oocyte1.00infobox
Janus kinase 2Bgeeblood1.00infobox
Janus kinase 2BgeePaneth cell1.00infobox
Janus kinase 2Bgeejejunum1.00infobox
Janus kinase 2Bgeeuterus1.00infobox
Janus kinase 2BgeeRostral migratory stream1.00infobox
Janus kinase 2Bgeefossa1.00infobox
Janus kinase 2Bgeemesenteric lymph nodes1.00infobox
Janus kinase 2BioGPSn/a1.00infobox
Janus kinase 2Chr.Chromosome 9 (human)1.00infobox
Janus kinase 2Chr.Chromosome 19 (mouse)1.00infobox
Janus kinase 2DatabasesNCBI: entry; OMA: entry1.00infobox
Janus kinase 2End5,129,948 bp1.00infobox

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