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ERBB3

Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.

Function, Role in cancer & Role in normal development

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Function

7 related topics

Role in cancer

2 related topics

Role in normal development

2 related topics

Overview

5 related topics

Key facts & relationships

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2.7.10.1
Aliases
ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK, VSCN1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS
Band
12q13.2 · 10 D3|10 77.1 cM
Bgee
trigeminal ganglion · jejunal mucosa · spinal ganglia · inferior ganglion of vagus nerve · corpus callosum
BioGPS
More reference expression data

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Overview

Function

Role in cancer

Role in normal development

Advanced semantic analysis

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Map overview Semantic statistics

ERBB3

Nodes21
Edges20
Triples176
Avg. degree1.9
Density0.095238
Components1

How this topic connects Entity context

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ERBB3

Top relations

Gene ontology · 66
ERBB3 → apical plasma membrane, ATP binding, basal plasma membrane, basolateral plasma membrane, cell differentiation, cranial nerve development, cytoplasm, development of the heart, endocardial cushion development, ERBB2 signaling pathway, extracellular region, extracellular space, extrinsic apoptotic signaling pathway in absence of ligand, growth factor binding, identical protein binding, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, kinase activity, lateral plasma membrane
Bgee · 20
ERBB3 → conjunctival fornix, corpus callosum, duodenum, epidermis, external globus pallidus, hair follicle, ileum, inferior ganglion of vagus nerve, intestinal villus, jejunal mucosa, jejunum, lacrimal gland, left colon, mucosa of colon, mucosa of ileum, mucosa of sigmoid colon, sciatic nerve, spinal ganglia, transitional epithelium of urinary bladder, trigeminal ganglion
RNA expression pattern · 20
ERBB3 → conjunctival fornix, corpus callosum, duodenum, epidermis, external globus pallidus, hair follicle, ileum, inferior ganglion of vagus nerve, intestinal villus, jejunal mucosa, jejunum, lacrimal gland, left colon, mucosa of colon, mucosa of ileum, mucosa of sigmoid colon, sciatic nerve, spinal ganglia, transitional epithelium of urinary bladder, trigeminal ganglion
related to Structure · 12
ERBB3 → Binding, C-terminal, ErbB, I-IV, II, III, IV, Subdomain II, Subdomains, Subdomains II, The, Unliganded
related to Interaction with ErbB2 · 10
ERBB3 → EGF-like, ErbB, ErbB2, ErbB2-ErbB3, MAPK, PI3K/Akt, PLCγ, The ErbB2-ErbB3, There, This
related to Function · 7
ERBB3 → EGFR, ErbB, Ligand, NRG-2, The, Therefore, Unlike
related to Activation of the PI3K/Akt pathway · 5
ERBB3 → EGFR, ErbB2, PI3K, SH2, The
related to Gene and expression · 3
ERBB3 → During, It, The
related to Role in normal development · 3
ERBB3 → Although, ErbB2, Schwann
Band · 2
ERBB3 → 10 D3|10 77.1 cM, 12q13.2

Important terminology Word statistics

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Important terminology

human receptor erbb2 family gene kinase erbb bp ligand binding protein growth chr band members tyrosine chromosome 12 also factor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ERBB32.7.10.11.00infobox
ERBB3AliasesERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK, VSCN11.00infobox
ERBB3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS1.00infobox
ERBB3Band12q13.21.00infobox
ERBB3Band10 D3|10 77.1 cM1.00infobox
ERBB3Bgeetrigeminal ganglion1.00infobox
ERBB3Bgeejejunal mucosa1.00infobox
ERBB3Bgeespinal ganglia1.00infobox
ERBB3Bgeeinferior ganglion of vagus nerve1.00infobox
ERBB3Bgeecorpus callosum1.00infobox
ERBB3Bgeemucosa of colon1.00infobox
ERBB3Bgeemucosa of ileum1.00infobox
ERBB3Bgeemucosa of sigmoid colon1.00infobox
ERBB3Bgeeduodenum1.00infobox
ERBB3Bgeeexternal globus pallidus1.00infobox
ERBB3Bgeeleft colon1.00infobox
ERBB3Bgeejejunum1.00infobox
ERBB3Bgeeileum1.00infobox
ERBB3Bgeeintestinal villus1.00infobox
ERBB3Bgeetransitional epithelium of urinary bladder1.00infobox
ERBB3Bgeelacrimal gland1.00infobox
ERBB3Bgeeepidermis1.00infobox
ERBB3Bgeehair follicle1.00infobox
ERBB3Bgeeconjunctival fornix1.00infobox
ERBB3Bgeesciatic nerve1.00infobox
ERBB3BioGPSMore reference expression data1.00infobox
ERBB3Chr.Chromosome 12 (human)1.00infobox
ERBB3Chr.Chromosome 10 (mouse)1.00infobox
ERBB3DatabasesNCBI: entry; OMA: entry1.00infobox
ERBB3End56,103,505 bp1.00infobox

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