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Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.
The analysis highlights Function, Role in cancer and Role in normal development as prominent areas in the source structure around ERBB3.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around ERBB3 shows recurring relationship patterns in the source. For example, ERBB3 → apical plasma membrane, ATP binding, basal plasma membrane, basolateral plasma membrane, cell differentiation, cranial nerve development, cytoplasm, development of the heart, endocardial cushion development, ERBB2 signaling pathway, extracellular region, extracellular space, extrinsic apoptotic signaling pathway in absence of ligand, growth factor binding, identical protein binding, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, kinase activity, lateral plasma membrane Another extracted example is ERBB3 → conjunctival fornix, corpus callosum, duodenum, epidermis, external globus pallidus, hair follicle, ileum, inferior ganglion of vagus nerve, intestinal villus, jejunal mucosa, jejunum, lacrimal gland, left colon, mucosa of colon, mucosa of ileum, mucosa of sigmoid colon, sciatic nerve, spinal ganglia, transitional epithelium of urinary bladder, trigeminal ganglion. Use these groups to spot repeated connection types before inspecting the individual relationships.
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human receptor erbb2 family gene kinase erbb bp ligand binding protein growth chr band members tyrosine chromosome 12 also factor
TTTA extracted 167 structured relationships around ERBB3. Examples in this analysis include ERBB3 → 2.7.10.1 → ↗ and ERBB3 → Aliases → ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK, VSCN1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ERBB3 | 2.7.10.1 | ↗ | 1.00 | infobox |
| ERBB3 | Aliases | ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK, VSCN1 | 1.00 | infobox |
| ERBB3 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS | 1.00 | infobox |
| ERBB3 | Band | 12q13.2 | 1.00 | infobox |
| ERBB3 | Band | 10 D3|10 77.1 cM | 1.00 | infobox |
| ERBB3 | Bgee | trigeminal ganglion | 1.00 | infobox |
| ERBB3 | Bgee | jejunal mucosa | 1.00 | infobox |
| ERBB3 | Bgee | spinal ganglia | 1.00 | infobox |
| ERBB3 | Bgee | inferior ganglion of vagus nerve | 1.00 | infobox |
| ERBB3 | Bgee | corpus callosum | 1.00 | infobox |
| ERBB3 | Bgee | mucosa of colon | 1.00 | infobox |
| ERBB3 | Bgee | mucosa of ileum | 1.00 | infobox |
| ERBB3 | Bgee | mucosa of sigmoid colon | 1.00 | infobox |
| ERBB3 | Bgee | duodenum | 1.00 | infobox |
| ERBB3 | Bgee | external globus pallidus | 1.00 | infobox |
| ERBB3 | Bgee | left colon | 1.00 | infobox |
| ERBB3 | Bgee | jejunum | 1.00 | infobox |
| ERBB3 | Bgee | ileum | 1.00 | infobox |
| ERBB3 | Bgee | intestinal villus | 1.00 | infobox |
| ERBB3 | Bgee | transitional epithelium of urinary bladder | 1.00 | infobox |
| ERBB3 | Bgee | lacrimal gland | 1.00 | infobox |
| ERBB3 | Bgee | epidermis | 1.00 | infobox |
| ERBB3 | Bgee | hair follicle | 1.00 | infobox |
| ERBB3 | Bgee | conjunctival fornix | 1.00 | infobox |
| ERBB3 | Bgee | sciatic nerve | 1.00 | infobox |
| ERBB3 | BioGPS | More reference expression data | 1.00 | infobox |
| ERBB3 | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| ERBB3 | Chr. | Chromosome 10 (mouse) | 1.00 | infobox |
| ERBB3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ERBB3 | End | 56,103,505 bp | 1.00 | infobox |
The concept neighborhoods around ERBB3 bring nearby vocabulary together. In this analysis, examples include Erbb2, Erbb and Family. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ERBB3, one of the stronger structural bridges in this analysis connects ERBB3 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ERBB3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Role in cancer & Role in normal development, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ERBB3 · EN edition · Analysis: TopicsToTalkAbout
