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PAX2: Regions, Function & Clinical significance

Paired box gene 2, also known as Pax-2, is a protein which in humans is encoded by the PAX2 gene.

Language: English [EN]
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PAX2 topic overview

The analysis highlights Regions, Function and Clinical significance as prominent areas in the source structure around PAX2.

Related topics
11
Source areas
4
Connected nodes
15
Extracted relationships
193
Concept neighborhoods
9
Bridge connections
15

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 4 topics
Clinical significance · 3 topics
Interactions · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PAX2, PAPRS, FSGS7, paired box 2, PAX-2
Band
10q24.31 · 19 C3|19 38.09 cM
Bgee
renal medulla · right uterine tube · human kidney · tail of epididymis · corpus epididymis
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PAX2 connects Entity context

The extracted context around PAX2 shows recurring relationship patterns in the source. For example, PAX2 → ageing, animal organ development, axonogenesis, brain morphogenesis, branching involved in ureteric bud morphogenesis, camera-type eye development, cell differentiation, cell fate determination, cellular response to epidermal growth factor stimulus, cellular response to glucose stimulus, cellular response to hydrogen peroxide, cellular response to retinoic acid, centriolar satellite, cis-regulatory region sequence-specific DNA binding, cochlea development, cochlea morphogenesis, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, glial cell differentiation Another extracted example is PAX2 → Concentration, DNA-binding, Drosophila, En, En1, Expression, Family, FGF8, In, It, Member, Mesencephalon, MHB, MHB-specific, Otx2-Gbx2, Paired-Box Containing Genes, Pax, Pax-2, Pax5, Pax8. Use these groups to spot repeated connection types before inspecting the individual relationships.

PAX2

Top relations

Gene ontology · 85
PAX2 → ageing, animal organ development, axonogenesis, brain morphogenesis, branching involved in ureteric bud morphogenesis, camera-type eye development, cell differentiation, cell fate determination, cellular response to epidermal growth factor stimulus, cellular response to glucose stimulus, cellular response to hydrogen peroxide, cellular response to retinoic acid, centriolar satellite, cis-regulatory region sequence-specific DNA binding, cochlea development, cochlea morphogenesis, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, glial cell differentiation
related to Function · 30
PAX2 → Concentration, DNA-binding, Drosophila, En, En1, Expression, Family, FGF8, In, It, Member, Mesencephalon, MHB, MHB-specific, Otx2-Gbx2, Paired-Box Containing Genes, Pax, Pax-2, Pax5, Pax8
Bgee · 20
PAX2 → corpus epididymis, endometrium, epithelium of epididymis, Gray matter of spinal cord, human kidney, kidney tubule, mesonephric duct, mesonephric tubules, mesonephros, neural ectoderm, optic recess, optic stalk, otic placode, paraflocculus of cerebellum, renal medulla, right uterine tube, seminal vesicula, tail of epididymis, testicle, ureteric bud
RNA expression pattern · 20
PAX2 → corpus epididymis, endometrium, epithelium of epididymis, Gray matter of spinal cord, human kidney, kidney tubule, mesonephric duct, mesonephric tubules, mesonephros, neural ectoderm, optic recess, optic stalk, otic placode, paraflocculus of cerebellum, renal medulla, right uterine tube, seminal vesicula, tail of epididymis, testicle, ureteric bud
related to External links · 8
PAX2 → GeneReviews/NCBI/NIH/UW, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Renal Coloboma SyndromePAX2, This, United States National Library
related to Clinical significance · 7
PAX2 → Alternative, Gata3, HGF, Mutations, Pathologically, Pax8, Without
Band · 2
PAX2 → 10q24.31, 19 C3|19 38.09 cM
Chr. · 2
PAX2 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
PAX2 → 100,829,944 bp, 44,837,871 bp
is a · 2
PAX2 → attractive therapeutic target and a number of methods for inhibiting its activity have been investigated, earliest known gene to be expressed across the Otx2-Gbx2 boundary

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp transcription factor chr band expression development chromosome 10 also kidney expressed system paired box protein renal region

PAX2 relationships Subject–Predicate–Object triples

TTTA extracted 193 structured relationships around PAX2. Examples in this analysis include PAX2 → Aliases → PAX2, PAPRS, FSGS7, paired box 2, PAX-2 and PAX2 → Band → 10q24.31. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PAX2AliasesPAX2, PAPRS, FSGS7, paired box 2, PAX-21.00infobox
PAX2Band10q24.311.00infobox
PAX2Band19 C3|19 38.09 cM1.00infobox
PAX2Bgeerenal medulla1.00infobox
PAX2Bgeeright uterine tube1.00infobox
PAX2Bgeehuman kidney1.00infobox
PAX2Bgeetail of epididymis1.00infobox
PAX2Bgeecorpus epididymis1.00infobox
PAX2Bgeeseminal vesicula1.00infobox
PAX2Bgeeendometrium1.00infobox
PAX2Bgeetesticle1.00infobox
PAX2Bgeeparaflocculus of cerebellum1.00infobox
PAX2Bgeekidney tubule1.00infobox
PAX2Bgeemesonephros1.00infobox
PAX2Bgeemesonephric tubules1.00infobox
PAX2Bgeemesonephric duct1.00infobox
PAX2Bgeeoptic stalk1.00infobox
PAX2Bgeeureteric bud1.00infobox
PAX2Bgeeotic placode1.00infobox
PAX2Bgeeneural ectoderm1.00infobox
PAX2Bgeeepithelium of epididymis1.00infobox
PAX2BgeeGray matter of spinal cord1.00infobox
PAX2Bgeeoptic recess1.00infobox
PAX2BioGPSMore reference expression data1.00infobox
PAX2Chr.Chromosome 10 (human)1.00infobox
PAX2Chr.Chromosome 19 (mouse)1.00infobox
PAX2DatabasesNCBI: entry; OMA: entry1.00infobox
PAX2End100,829,944 bp1.00infobox
PAX2End44,837,871 bp1.00infobox
PAX2EnsemblENSG000000758911.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PAX2 bring nearby vocabulary together. In this analysis, examples include Kidney, Expression and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PAX2
    • Kidney
    • Expression
    • Human
    • Transcription
    • Pax8
    • Renal
    • Expressed
    • Factor
    • Cell
    • Nerve
    • Protein
    • Region
  • pax2
    • Kidney
    • Expression
    • Human
    • Transcription
    • Pax8
    • Renal
    • Expressed
    • Factor
    • Cell
    • Nerve
    • Protein
    • Region
  • gene
    • Human
    • Paired
    • Pax2
    • Location
    • Factor
    • Central
    • Chromosome
    • Bp
    • Chr
    • Transcription
    • Function
    • Mouse
  • transcription factor
    • Growth
    • Factor
    • Transcription
    • Development
    • Nervous
    • Organization
    • Signaling
    • Central
    • System
    • Gene
    • Fgf8
    • Nerve
  • function
    • Location
    • Chromosome
    • Bp
    • Chr
    • Mouse
    • Human
    • Cell
    • Nerve
    • Nervous
    • Organization
    • Pax
    • Pax-2
  • paired box
    • Paired
    • Pax-2
    • Gene
    • Also
    • External
    • Human
    • Function
    • Location
    • Protein
    • Central
    • Chromosome
    • Bp
  • protein
    • Pax
    • Renal
    • Nerve
    • Nervous
    • Organization
    • Signaling
    • Region
    • System
    • Transcription
  • renal hypoplasia
    • Nerve
    • Pax
    • Protein
    • Nervous
    • Organization
    • Signaling
    • Region
    • System
    • Transcription

Connections between topic areas Semantic bridges

For PAX2, one of the stronger structural bridges in this analysis connects PAX2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PAX2Function · splits 11 ⟂ 5
PAX2Clinical significance · splits 12 ⟂ 4
PAX2Overview · splits 13 ⟂ 3
PAX2Interactions · splits 13 ⟂ 3

Map overview Semantic statistics

PAX2

Nodes16
Edges15
Triples193
Avg. degree1.88
Density0.125
Components1

Source & methodology

TTTA analyzes the structure around PAX2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PAX2 · EN edition · Analysis: TopicsToTalkAbout

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