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Neratinib

Neratinib (INN), sold under the brand name Nerlynx, is a tyrosine kinase inhibitor anti-cancer medication used for the treatment of breast cancer.

History & Applications

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Explore the main themes, entities and connections around Neratinib. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EH02 (WHO)
CAS Number
698387-09-6 N
ChEMBL
ChEMBL180022 Y
ChemSpider
8091392 Y

Topics to explore

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Overview

Medical uses

Adverse effects

Interactions

Pharmacology

History

Advanced semantic analysis

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Map overview Semantic statistics

Neratinib

Nodes33
Edges32
Triples89
Avg. degree1.94
Density0.060606
Components1

How this topic connects Entity context

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Neratinib

Top relations

related to External links · 17
Neratinib → Archived, Clinical, ClinicalTrials, Drug Information Portal, Early Stage Breast Cancer, ExteNET, July, Medicine, National Cancer Institute, National Library, NCI Drug Dictionary, NCT00878709, November, October, Of Neratinib After Adjuvant, Study Evaluating The Effects, Trastuzumab In Women With
related to Pharmacology · 14
Neratinib → A431, D1, EGFR, Her2, IC50, In, In BT474, It, KDR, Like, Scr, SK-OV-3, T790M, Unlike
related to history · 11
Neratinib → Approval, ExteNET, HER2-overexpressed/amplified, It, July, NCT00878709, Pfizer, Phase III, Puma Biotechnology, United States, Wyeth
related to Medical uses · 6
Neratinib → European Union, HER2, HER2-overexpressed/amplified, HER2-positive, In, United States
Legal status · 5
Neratinib → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Interactions · 5
Neratinib → Antacids, CYP3A4, Drugs, H2-receptor, People
related to Cell biology · 4
Neratinib → HER2, However, IC50, SKBR3
License data · 3
Neratinib → EU EMA: by INN, US DailyMed: Neratinib, US FDA: Nerlynx
KEGG · 2
Neratinib → as salt: D10898 Y, D08950 Y
has effect · 2
Neratinib → In, Similarly

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer breast her2 treatment effects side drug name adjuvant use national nausea vomiting pain common inn nerlynx medical brand drugs

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Neratinib3D model (JSmol)Interactive image1.00infobox
NeratinibAHFS/Drugs.comMonograph1.00infobox
NeratinibATC codeL01EH02 (WHO)1.00infobox
NeratinibCAS Number698387-09-6 N1.00infobox
NeratinibChEMBLChEMBL180022 Y1.00infobox
NeratinibChemSpider8091392 Y1.00infobox
NeratinibCompTox Dashboard (EPA)DTXSID702201321.00infobox
NeratinibDrug classAntineoplastic agent1.00infobox
NeratinibDrugBankDB11828 N1.00infobox
NeratinibECHA InfoCard100.241.5121.00infobox
NeratinibFormulaC30H29ClN6O31.00infobox
NeratinibIUPHAR/BPS56861.00infobox
NeratinibKEGGD08950 Y1.00infobox
NeratinibKEGGas salt: D10898 Y1.00infobox
NeratinibLegal statusAU: S4 (Prescription only)1.00infobox
NeratinibLegal statusCA: ℞-only1.00infobox
NeratinibLegal statusUK: POM (Prescription only)1.00infobox
NeratinibLegal statusUS: ℞-only1.00infobox
NeratinibLegal statusEU: Rx-only1.00infobox
NeratinibLicense dataEU EMA: by INN1.00infobox
NeratinibLicense dataUS DailyMed: Neratinib1.00infobox
NeratinibLicense dataUS FDA: Nerlynx1.00infobox
NeratinibMedlinePlusa6170341.00infobox
NeratinibMolar mass557.05 g·mol−11.00infobox
NeratinibOther namesHKI-2721.00infobox
NeratinibPregnancy categoryAU: D1.00infobox
NeratinibPubChem CID99157431.00infobox
NeratinibRoutes of administrationBy mouth1.00infobox
NeratinibTrade namesNerlynx, Hernix1.00infobox
NeratinibUNIIJJH94R3PWB1.00infobox

Related concept clusters Concept neighborhoods

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