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Lapatinib: Art, Mode of action & Overview

Lapatinib (INN), used in the form of lapatinib ditosylate (USAN) (trade names Tykerb and Tyverb marketed by Novartis) is an orally active drug for breast cancer and other solid tumours. It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. It is used in combination therapy for…

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Lapatinib topic overview

The analysis highlights Art, Mode of action and Overview as prominent areas in the source structure around Lapatinib.

Related topics
40
Source areas
4
Connected nodes
44
Extracted relationships
92
Concept neighborhoods
23
Bridge connections
44

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 18 topics
Mode of action · 10 topics
Adverse effects · 8 topics
Status · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EH01 (WHO)
Bioavailability
Variable, increased with food
CAS Number
231277-92-2 N · as salt: 388082-78-8 N
ChEBI
CHEBI:49603 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Status

Mode of action

Adverse effects

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Lapatinib connects Entity context

The extracted context around Lapatinib shows recurring relationship patterns in the source. For example, Lapatinib → Australia, Bahrain, Brazil, Drug Administration, Europe, European Union, FDA, Food, GlaxoSmithKline, GSK, HER2, In January, In March, India, Japan, Jordan, Kuwait, Lebanon, New Zealand, Pakistan Another extracted example is Lapatinib → Diarrhoea, HER2-positive, Median PFS, OS, PFS, Phase III, SAE, Secondary, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Lapatinib

Top relations

related to Status · 30
Lapatinib → Australia, Bahrain, Brazil, Drug Administration, Europe, European Union, FDA, Food, GlaxoSmithKline, GSK, HER2, In January, In March, India, Japan, Jordan, Kuwait, Lebanon, New Zealand, Pakistan
related to Ongoing trials in gastric cancer · 9
Lapatinib → Diarrhoea, HER2-positive, Median PFS, OS, PFS, Phase III, SAE, Secondary, The
Legal status · 6
Lapatinib → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
has effect · 6
Lapatinib → Caution, In, Like, Of, QT, The
related to Biochemistry · 4
Lapatinib → EGFR, HER2/neu, Like, Over
related to External links · 4
Lapatinib → Lapatinib Ditosylate, March, National Cancer Institute, NCI Drug Dictionary
CAS Number · 2
Lapatinib → 231277-92-2 N, as salt: 388082-78-8 N
ChEMBL · 2
Lapatinib → as salt: ChEMBL1201179 Y, ChEMBL554 Y
ChemSpider · 2
Lapatinib → 181006 Y, as salt: 9731817 Y
DrugBank · 2
Lapatinib → as salt: DBSALT001785 Y, DB01259 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer breast combination her2 patients kinase drug used tykerb ditosylate egfr clinical capecitabine chemotherapy tyrosine receptor therapy her2-positive treatment names

Lapatinib relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around Lapatinib. Examples in this analysis include Lapatinib → 3D model (JSmol) → Interactive image and Lapatinib → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Lapatinib3D model (JSmol)Interactive image1.00infobox
LapatinibAHFS/Drugs.comMonograph1.00infobox
LapatinibATC codeL01EH01 (WHO)1.00infobox
LapatinibBioavailabilityVariable, increased with food1.00infobox
LapatinibCAS Number231277-92-2 N1.00infobox
LapatinibCAS Numberas salt: 388082-78-8 N1.00infobox
LapatinibChEBICHEBI:49603 Y1.00infobox
LapatinibChEMBLChEMBL554 Y1.00infobox
LapatinibChEMBLas salt: ChEMBL1201179 Y1.00infobox
LapatinibChemSpider181006 Y1.00infobox
LapatinibChemSpideras salt: 9731817 Y1.00infobox
LapatinibCompTox Dashboard (EPA)DTXSID70466751.00infobox
LapatinibDrugBankDB01259 Y1.00infobox
LapatinibDrugBankas salt: DBSALT001785 Y1.00infobox
LapatinibElimination half-life24 hours (repeated dosing), 14.2 hours (single dose)1.00infobox
LapatinibExcretionMostly Feces1.00infobox
LapatinibFormulaC29H26ClFN4O4S1.00infobox
LapatinibIUPHAR/BPS56921.00infobox
LapatinibKEGGD08108 N1.00infobox
LapatinibKEGGas salt: D04024 N1.00infobox
LapatinibLegal statusAU: S4 (Prescription only)1.00infobox
LapatinibLegal statusCA: ℞-only1.00infobox
LapatinibLegal statusUK: POM (Prescription only)1.00infobox
LapatinibLegal statusUS: ℞-only1.00infobox
LapatinibLegal statusEU: Rx-only1.00infobox
LapatinibLegal statusIn general: ℞ (Prescription only)1.00infobox
LapatinibLicense dataUS DailyMed: Lapatinib1.00infobox
LapatinibMedlinePlusa6070551.00infobox
LapatinibMetabolismLiver, mostly CYP3A-mediated (minor 2C19 and 2C8 involvement)1.00infobox
LapatinibMolar mass581.06 g·mol−11.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Lapatinib bring nearby vocabulary together. In this analysis, examples include Cancer, Breast and Ditosylate. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Lapatinib
    • Cancer
    • Breast
    • Ditosylate
    • Combination
    • Chemotherapy
    • Kinase
    • Patients
    • Anthracycline
    • Protein
    • Trastuzumab
    • Capecitabine
    • Egfr
  • lapatinib
    • Cancer
    • Breast
    • Ditosylate
    • Combination
    • Chemotherapy
    • Kinase
    • Patients
    • Anthracycline
    • Protein
    • Trastuzumab
    • Capecitabine
    • Egfr
  • breast cancer
    • Cancer
    • Lapatinib
    • Combination
    • Treatment
    • Used
    • Her2-positive
    • Her2
    • Anthracycline
    • Trastuzumab
    • Women
    • Advanced
    • Capecitabine
  • combination
    • Capecitabine
    • Therapy
    • Chemotherapy
    • Alone
    • Her2-positive
    • Study
    • Patients
    • Lapatinib
    • Anthracycline
    • Common
    • Group
    • Trastuzumab
  • metastatic breast cancer
    • Cancer
    • Lapatinib
    • Combination
    • Treatment
    • Used
    • Her2-positive
    • Her2
    • Anthracycline
    • Trastuzumab
    • Women
    • Advanced
    • Capecitabine
  • cancer stem cells
    • Lapatinib
    • Combination
    • Her2-positive
    • Used
    • Advanced
    • Anthracycline
    • Trastuzumab
    • Capecitabine
    • Therapy
    • Treatment
    • Tykerb
    • Her2
  • her2/neu
    • Egfr
    • Receptor
    • Growth
    • Neu
    • Tyrosine
    • Treatment
    • Kinase
    • Advanced
    • Women
    • Used
    • Associated
    • Patients
  • epidermal growth factor receptor
    • Egfr
    • Tyrosine
    • Neu
    • Receptor
    • Kinase
    • Her2
    • Inhibitor
    • Alone
    • Anthracycline
    • Associated
    • Trastuzumab
    • Capecitabine

Connections between topic areas Semantic bridges

For Lapatinib, one of the stronger structural bridges in this analysis connects Lapatinib with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Lapatinib — Overview · splits 26 ⟂ 19
Lapatinib — Mode of action · splits 34 ⟂ 11
Lapatinib — Adverse effects · splits 36 ⟂ 9
Lapatinib — Status · splits 40 ⟂ 5

Map overview Semantic statistics

Lapatinib

Nodes45
Edges44
Triples92
Avg. degree1.96
Density0.044444
Components1

Source & methodology

TTTA analyzes the structure around Lapatinib to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Mode of action & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Lapatinib · EN edition · Analysis: TopicsToTalkAbout

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