Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Lapatinib

Lapatinib (INN), used in the form of lapatinib ditosylate (USAN) (trade names Tykerb and Tyverb marketed by Novartis) is an orally active drug for breast cancer and other solid tumours. It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. It is used in combination therapy for…

Art, Mode of action & Overview

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Lapatinib. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EH01 (WHO)
Bioavailability
Variable, increased with food
CAS Number
231277-92-2 N · as salt: 388082-78-8 N
ChEBI
CHEBI:49603 Y

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Status

Mode of action

Adverse effects

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Lapatinib

Nodes45
Edges44
Triples92
Avg. degree1.96
Density0.044444
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Lapatinib

Top relations

related to Status · 30
Lapatinib → Australia, Bahrain, Brazil, Drug Administration, Europe, European Union, FDA, Food, GlaxoSmithKline, GSK, HER2, In January, In March, India, Japan, Jordan, Kuwait, Lebanon, New Zealand, Pakistan
related to Ongoing trials in gastric cancer · 9
Lapatinib → Diarrhoea, HER2-positive, Median PFS, OS, PFS, Phase III, SAE, Secondary, The
Legal status · 6
Lapatinib → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
has effect · 6
Lapatinib → Caution, In, Like, Of, QT, The
related to Biochemistry · 4
Lapatinib → EGFR, HER2/neu, Like, Over
related to External links · 4
Lapatinib → Lapatinib Ditosylate, March, National Cancer Institute, NCI Drug Dictionary
CAS Number · 2
Lapatinib → 231277-92-2 N, as salt: 388082-78-8 N
ChEMBL · 2
Lapatinib → as salt: ChEMBL1201179 Y, ChEMBL554 Y
ChemSpider · 2
Lapatinib → 181006 Y, as salt: 9731817 Y
DrugBank · 2
Lapatinib → as salt: DBSALT001785 Y, DB01259 Y

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer breast combination her2 patients kinase drug used tykerb ditosylate egfr clinical capecitabine chemotherapy tyrosine receptor therapy her2-positive treatment names

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Lapatinib3D model (JSmol)Interactive image1.00infobox
LapatinibAHFS/Drugs.comMonograph1.00infobox
LapatinibATC codeL01EH01 (WHO)1.00infobox
LapatinibBioavailabilityVariable, increased with food1.00infobox
LapatinibCAS Number231277-92-2 N1.00infobox
LapatinibCAS Numberas salt: 388082-78-8 N1.00infobox
LapatinibChEBICHEBI:49603 Y1.00infobox
LapatinibChEMBLChEMBL554 Y1.00infobox
LapatinibChEMBLas salt: ChEMBL1201179 Y1.00infobox
LapatinibChemSpider181006 Y1.00infobox
LapatinibChemSpideras salt: 9731817 Y1.00infobox
LapatinibCompTox Dashboard (EPA)DTXSID70466751.00infobox
LapatinibDrugBankDB01259 Y1.00infobox
LapatinibDrugBankas salt: DBSALT001785 Y1.00infobox
LapatinibElimination half-life24 hours (repeated dosing), 14.2 hours (single dose)1.00infobox
LapatinibExcretionMostly Feces1.00infobox
LapatinibFormulaC29H26ClFN4O4S1.00infobox
LapatinibIUPHAR/BPS56921.00infobox
LapatinibKEGGD08108 N1.00infobox
LapatinibKEGGas salt: D04024 N1.00infobox
LapatinibLegal statusAU: S4 (Prescription only)1.00infobox
LapatinibLegal statusCA: ℞-only1.00infobox
LapatinibLegal statusUK: POM (Prescription only)1.00infobox
LapatinibLegal statusUS: ℞-only1.00infobox
LapatinibLegal statusEU: Rx-only1.00infobox
LapatinibLegal statusIn general: ℞ (Prescription only)1.00infobox
LapatinibLicense dataUS DailyMed: Lapatinib1.00infobox
LapatinibMedlinePlusa6070551.00infobox
LapatinibMetabolismLiver, mostly CYP3A-mediated (minor 2C19 and 2C8 involvement)1.00infobox
LapatinibMolar mass581.06 g·mol−11.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.