Pharmacogenomics

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Explore the main themes, entities and connections around Pharmacogenomics. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Applications

Pain management Cardiology Psychiatric Forensic pathology Autopsy

30 related topics

History

Pythagoras Fava bean Oxidative stress 1950s G6PD

11 related topics

Overview

Genome Drug Genomics Pharmacology Somatic mutations

74 related topics

Common pharmacogenomic-specific nomenclature

Nomenclature Haplotypes Single-nucleotide polymorphisms Base pair Amino acid

7 related topics

Topics to explore

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Overview

Genome
Drug
Genomics
Pharmacology
Somatic mutations Somatic mutation
Germline mutations Germline mutation
Mutations Mutation
Point mutations Point mutation
Copy number variations Copy number variation
Structural variations Structural variation in the human genome
Pharmacokinetic Pharmacokinetics
Absorption Absorption (pharmacokinetics)
Distribution Distribution (pharmacology)
Metabolism
Elimination Clearance (medicine)
Pharmacodynamic Pharmacodynamics
Biological targets Biological target
Immunogenic Immunogenicity
Drug therapy Pharmacotherapy
Genotype
Adverse effects Adverse effect (medicine)
Pharmaceutical drug
Precision medicine
Personalized medicine
Genotyping
Exome
Sequencing
Stop codon
Phase I Phase I metabolism
Phase II Phase II metabolism

Pharmacogenetics vs. pharmacogenomics

Monogenic Monogenic (genetics)
Transcriptomics Transcriptome
Proteomics
Metabolomics

Mechanisms of pharmacogenetic interactions

Clinical pharmacogenomics resources

Clinical Pharmacogenetics Implementation Consortium
Pharmacogenomics Knowledgebase (PharmGKB) PharmGKB
NIH National Institutes of Health

Commercial pharmacogenetic testing laboratories

Laboratory developed test (LDTs) Laboratory developed test
United States
CLIA Clinical Laboratory Improvement Amendments
Direct-to-consumer Direct-to-consumer genetic testing

Common pharmacogenomic-specific nomenclature

Nomenclature
Haplotypes Haplotype
Single-nucleotide polymorphisms Single-nucleotide polymorphism
Base pair
Amino acid
Survey Survey (human research)
Phenotype

Applications

Pain management
Cardiology
Psychiatric Psychiatry
Forensic pathology
Autopsy
Cancer treatment
Cancer drugs
KRAS
Cetuximab
DPD Dihydropyrimidine dehydrogenase
TPMT
CDA Cytidine deaminase
Cardiovascular disorders Cardiovascular disease
Clopidogrel
Beta blockers Beta blocker
Statins Statin
Medication package insert
Type 2 diabetes
Haptoglobin
HDL High-density lipoprotein
5-HTTLPR
DRD2 Dopamine receptor D2
Europe
Vanderbilt University Medical Center
UnitedHealthcare UnitedHealth Group
Canada
Green Shield Canada
Polypharmacy
Adverse drug reactions Adverse drug reaction
Boston University

Example case studies

Advanced semantic analysis

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Map overview Semantic statistics

Nodes165

Edges164

Triples106

Avg. degree1.99

Density0.012121

Components1

How this topic connects Entity context

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Pharmacogenomics

Top relations

related to External links · 22

Pharmacogenomics → Archived, Biotechnology Information, Center, Chapel Hill Center, Drug Administration, February, Food, Individualized Therapy, Journals, June, Medicine, National Center, National Library, NCBI, North Carolina, Personalized Medicine, Pharmacogenetics, Pharmacogenomics Education Initiatives, Pharmacogenomics Factsheet, Retrieved

related to Clinical implementation · 15

Pharmacogenomics → Care, Clinical Pharmacogenetics Implementation Consortium, CPIC, Enhanced Decisions, Europe, European, In, Initiatives, Pharmacogenomic Resource, PREDICT, Treatment, U-PGx, Ubiquitous Pharmacogenomics, United States, Vanderbilt University Medical Center

related to Example case studies · 14

Pharmacogenomics → After, Although, Antipsychotic, Case, CYP2C19, CYP2D6, Five, IM, Over, Patient, The, Their, Trazodone, When

related to history · 13

Pharmacogenomics → Although, BC, CYP2C19, CYP2D6, FDA, Friedrich Vogel, G6PD, Germany, Heidelberg, In, Pythagoras, Reports, The

related to Reduction of polypharmacy · 9

Pharmacogenomics → April, Boston University, February, For, Polypharmacy, Slone Epidemiology Center, The, Thus, United States

related to Challenges · 5

Pharmacogenomics → Although, Combining, Limitation, Some, The

has application · 4

Pharmacogenomics → ADRs, Improve, Tailor, The

related to Pharmacogenetics vs. pharmacogenomics · 3

Pharmacogenomics → Although, Pharmacogenetics, The

related to PharmGKB · 3

Pharmacogenomics → NIH-funded, PharmGKB, The Pharmacogenomics Knowledgebase

see also · 2

Pharmacogenomics → CTHPOHGVSHL7FHIR Genetic, GenomicsChemogenomicsClinomicsGenetic

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

drug genetic pharmacogenetic clinical response patients test patient drugs information pharmacogenetics medications may also used include use tests testing medicine

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
drug transporters or drug metabolizing enzymes	instance of	These processes are often facilitated by enzymes	0.80	text
the blood	instance of	and TPMT.Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
gut lumen	instance of	and TPMT.Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
bile	instance of	and TPMT.Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
urine	instance of	and TPMT.Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
brain	instance of	and TPMT.Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
and cerebrospinal fluid	instance of	and TPMT.Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
the blood	instance of	Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
gut lumen	instance of	Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
bile	instance of	Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
urine	instance of	Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text
brain	instance of	Drug transportersMany medications rely on transporters to cross cellular membranes in order to move between body fluid compartments	0.80	text

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Connections between topic areas Semantic bridges

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Research this topic

Explore this topic

Applications

History

Overview

Common pharmacogenomic-specific nomenclature

Key facts & relationships

Topics to explore

Overview

Pharmacogenetics vs. pharmacogenomics

Mechanisms of pharmacogenetic interactions

Clinical pharmacogenomics resources

Commercial pharmacogenetic testing laboratories

Common pharmacogenomic-specific nomenclature

Applications

Example case studies

Challenges

Controversies

History

Future

Ethics

Advanced semantic analysis

Map overview Semantic statistics

Pharmacogenomics

How this topic connects Entity context

Pharmacogenomics

Top relations

Important terminology Word statistics

Important terminology

Entity relationships Subject–Predicate–Object triples

Related concept clusters Concept neighborhoods

Connections between topic areas Semantic bridges