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HSPA8

Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in humans is encoded by the HSPA8 gene on chromosome 11. As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or…

Clinical significance, Interactions & Function

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Clinical significance

31 related topics

Interactions

16 related topics

Function

12 related topics

Structure

5 related topics

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3.6.4.10
Aliases
HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 4HWI, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4KBQ
Band
11q24.1 · 9 A5.1|9 21.55 cM
Bgee
corpus callosum · superior frontal gyrus · right hemisphere of cerebellum · prefrontal cortex · right frontal lobe
BioGPS
More reference expression data

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Overview

Structure

Function

Clinical significance

Interactions

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HSPA8

Nodes80
Edges79
Triples188
Avg. degree1.98
Density0.025
Components1

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HSPA8

Top relations

Gene ontology · 94
HSPA8 → ATP binding, ATP metabolic process, ATPase activity, autophagosome, axo-dendritic transport, axon, blood microparticle, C3HC4-type RING finger domain binding, cadherin binding, cellular response to heat, cellular response to starvation, chaperone binding, chaperone cofactor-dependent protein refolding, chaperone complex, chaperone-mediated autophagy, chaperone-mediated autophagy translocation complex disassembly, clathrin coat disassembly, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane, clathrin-uncoating ATPase activity, cytokine-mediated signaling pathway
related to Clinical significance · 24
HSPA8 → AFP-expressing, Alternatively, Alzheimer's, Apoptosis, As, DNA, During, Elevated Hsp70, Hsc70, Hsp70, Hsp70s, Hsp72, Hsp72/AFP, Huntington's, In, It, Its, One, Parkinson's, The
Bgee · 18
HSPA8 → corpus callosum, ganglionic eminence, genital tubercle, gonad, hippocampus proper, mesencephalon, neural tube, ovary, prefrontal cortex, primary visual cortex, proximal tubule, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, superior frontal gyrus, tail of embryo, ventricular zone
RNA expression pattern · 18
HSPA8 → corpus callosum, ganglionic eminence, genital tubercle, gonad, hippocampus proper, mesencephalon, neural tube, ovary, prefrontal cortex, primary visual cortex, proximal tubule, right frontal lobe, right hemisphere of cerebellum, right kidney, right testis, superior frontal gyrus, tail of embryo, ventricular zone
related to Interactions · 7
HSPA8 → BAG1, Bcl2-associated, HIP, HOP, Hsc70, Hsp40, Hsp90
Band · 2
HSPA8 → 11q24.1, 9 A5.1|9 21.55 cM
Chr. · 2
HSPA8 → Chromosome 11 (human), Chromosome 9 (mouse)
End · 2
HSPA8 → 123,063,230 bp, 40,721,383 bp
3.6.4.10 · 1
HSPA8 → ↗
Aliases · 1
HSPA8 → HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8

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Important terminology

protein hsc70 hsp70 cell heat shock proteins human bp chromosome 11 gene chr apoptosis band also processes 70 member folding

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HSPA83.6.4.101.00infobox
HSPA8AliasesHSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 81.00infobox
HSPA8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 4HWI, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4KBQ1.00infobox
HSPA8Band11q24.11.00infobox
HSPA8Band9 A5.1|9 21.55 cM1.00infobox
HSPA8Bgeecorpus callosum1.00infobox
HSPA8Bgeesuperior frontal gyrus1.00infobox
HSPA8Bgeeright hemisphere of cerebellum1.00infobox
HSPA8Bgeeprefrontal cortex1.00infobox
HSPA8Bgeeright frontal lobe1.00infobox
HSPA8Bgeeventricular zone1.00infobox
HSPA8Bgeegonad1.00infobox
HSPA8Bgeeganglionic eminence1.00infobox
HSPA8Bgeeright testis1.00infobox
HSPA8Bgeeprimary visual cortex1.00infobox
HSPA8Bgeetail of embryo1.00infobox
HSPA8Bgeegenital tubercle1.00infobox
HSPA8Bgeeovary1.00infobox
HSPA8Bgeemesencephalon1.00infobox
HSPA8Bgeeneural tube1.00infobox
HSPA8Bgeeright kidney1.00infobox
HSPA8Bgeehippocampus proper1.00infobox
HSPA8Bgeeproximal tubule1.00infobox
HSPA8BioGPSMore reference expression data1.00infobox
HSPA8Chr.Chromosome 11 (human)1.00infobox
HSPA8Chr.Chromosome 9 (mouse)1.00infobox
HSPA8DatabasesNCBI: entry; OMA: entry1.00infobox
HSPA8End123,063,230 bp1.00infobox
HSPA8End40,721,383 bp1.00infobox
HSPA8EnsemblENSG000001099711.00infobox

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