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Phenprocoumon: History & Applications

Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting anticoagulant to be taken by mouth, and a coumarin derivative. It acts as a vitamin K antagonist and inhibits blood clotting (coagulation) by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of…

Language: English [EN]
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Phenprocoumon topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Phenprocoumon. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
92
Source areas
10
Connected nodes
103
Extracted relationships
88
Concept neighborhoods
27
Bridge connections
103

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 17 topics
Medical uses · 15 topics
Pharmacology · 15 topics
Overview · 11 topics
Adverse effects · 9 topics
Chemistry · 8 topics
Contraindications · 7 topics
Comparison with other anticoagulants · 5 topics
History · 3 topics
Overdose · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
International Drug Names
ATC code
B01AA04 (WHO)
Bioavailability
100%
CAS Number
435-97-2 Y
ChEBI
CHEBI:50438 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

Comparison with other anticoagulants

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Phenprocoumon connects Entity context

The extracted context around Phenprocoumon shows recurring relationship patterns in the source. For example, Phenprocoumon → Antibiotics, CYP2C9, CYP3A4, Due, Food, High, NSAIDs, Some, St John's, Substances Another extracted example is Phenprocoumon → Also, Direct, Finally, INR, On, There, They, Xa, Xabans. Use these groups to spot repeated connection types before inspecting the individual relationships.

Phenprocoumon

Top relations

related to Interactions · 10
Phenprocoumon → Antibiotics, CYP2C9, CYP3A4, Due, Food, High, NSAIDs, Some, St John's, Substances
related to Direct factor Xa inhibitors · 9
Phenprocoumon → Also, Direct, Finally, INR, On, There, They, Xa, Xabans
related to Dosing · 8
Phenprocoumon → After, Alternatively, If, INR, LMWH, Similarly, This, When
related to Mechanism of action · 8
Phenprocoumon → After, II, Inhibiting, IX, This, VII, Vitamin, VKOR
related to Warfarin · 8
Phenprocoumon → Both, CYP2C9, CYP3A4, For, INR, The, There, Warfarin
related to Pharmacogenomics · 5
Phenprocoumon → CYP2C9, Genetic, INR, Polymorphisms, VKORC1
related to Overdose · 4
Phenprocoumon → Bleeding, Mild, Overdosing, Taking
related to Chemistry · 2
Phenprocoumon → It, The
3D model (JSmol) · 1
Phenprocoumon → Interactive image
AHFS/Drugs.com · 1
Phenprocoumon → International Drug Names

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bleeding vitamin effect cyp2c9 warfarin blood drugs cyp3a4 inr coagulation used interactions half-life days drug therapy hours also factors large

Phenprocoumon relationships Subject–Predicate–Object triples

TTTA extracted 88 structured relationships around Phenprocoumon. Examples in this analysis include Phenprocoumon → 3D model (JSmol) → Interactive image and Phenprocoumon → AHFS/Drugs.com → International Drug Names. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Phenprocoumon3D model (JSmol)Interactive image1.00infobox
PhenprocoumonAHFS/Drugs.comInternational Drug Names1.00infobox
PhenprocoumonATC codeB01AA04 (WHO)1.00infobox
PhenprocoumonBioavailability100%1.00infobox
PhenprocoumonCAS Number435-97-2 Y1.00infobox
PhenprocoumonChEBICHEBI:50438 Y1.00infobox
PhenprocoumonChEMBLChEMBL1465 Y1.00infobox
PhenprocoumonChemSpider10441592 Y1.00infobox
PhenprocoumonCompTox Dashboard (EPA)DTXSID50234591.00infobox
PhenprocoumonDrugBankDB00946 Y1.00infobox
PhenprocoumonECHA InfoCard100.006.4641.00infobox
PhenprocoumonElimination half-life6–7 days1.00infobox
PhenprocoumonExcretionKidney1.00infobox
PhenprocoumonFormulaC18H16O31.00infobox
PhenprocoumonIUPHAR/BPS68391.00infobox
PhenprocoumonKEGGD05457 Y1.00infobox
PhenprocoumonLegal statusIn general: ℞ (Prescription only)1.00infobox
PhenprocoumonMedlinePlusa6990031.00infobox
PhenprocoumonMelting point177–181 °C (351–358 °F)1.00infobox
PhenprocoumonMetabolismLiver (CYP2C9, CYP3A4)1.00infobox
PhenprocoumonMetabolitesHydroxyl derivatives, glucuronides1.00infobox
PhenprocoumonMolar mass280.323 g·mol−11.00infobox
PhenprocoumonPregnancy categoryContraindicated1.00infobox
PhenprocoumonProtein binding99%1.00infobox
PhenprocoumonPubChem CID99081.00infobox
PhenprocoumonRoutes of administrationBy mouth1.00infobox
PhenprocoumonTrade namesMarcoumar, Marcumar, Falithrom1.00infobox
PhenprocoumonUNIIQ08SIO485D1.00infobox
Phenprocoumonis ainhibitor of the enzyme vitamin K epoxide reductase0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Phenprocoumon bring nearby vocabulary together. In this analysis, examples include Warfarin, Surgery and Hours. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • blood clotting
    • Clotting
    • Phenprocoumon
    • Inhibitors
    • Liver
    • Number
    • Protein
    • Surgery
    • Risk
    • Mouth
    • Therapy
    • Adverse
    • Brain
  • warfarin necrosis
    • Phenprocoumon
    • Adverse
    • Action
    • Cyp3a4
    • Days
    • Half-life
    • Interactions
    • Cyp2c9
    • Mouth
    • Clotting
    • Inhibitors
    • Liver
  • warfarin
    • Phenprocoumon
    • Adverse
    • Action
    • Cyp3a4
    • Days
    • Half-life
    • Interactions
    • Cyp2c9
    • Mouth
    • Clotting
    • Inhibitors
    • Liver
  • cyp2c9
    • Cyp3a4
    • Liver
    • Inhibitors
    • Number
    • Protein
    • Concentrations
    • Risk
    • Interactions
    • Phenprocoumon
    • Warfarin
    • Drugs
    • Mouth
  • nonsteroidal anti-inflammatory drugs
    • Interactions
    • Food
    • Number
    • Protein
    • Liver
    • Therapeutic
    • Concentrations
    • Large
    • Risk
    • Cyp3a4
    • Half-life
    • Phenprocoumon
  • adverse effects
    • Effect
    • Days
    • Warfarin
    • Mouth
    • Bleeding
    • Clotting
    • Inhibitors
    • Liver
    • Number
    • Protein
    • Severe
    • Surgery
  • cyp3a4
    • Liver
    • Inhibitors
    • Number
    • Protein
    • Risk
    • Also
    • Interactions
    • Warfarin
    • Drugs
    • Mouth
    • Phenprocoumon
    • Food
  • bleeding diathesis
    • Brain
    • Increase
    • Risk
    • Severe
    • Inhibitors
    • Surgery
    • Phenprocoumon
    • Concentrations
    • Blood
    • Effect
    • Vitamin
    • Clotting

Connections between topic areas Semantic bridges

For Phenprocoumon, one of the stronger structural bridges in this analysis connects Phenprocoumon with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Phenprocoumon — Interactions · splits 86 ⟂ 18
Phenprocoumon — Medical uses · splits 88 ⟂ 16
Phenprocoumon — Pharmacology · splits 88 ⟂ 16
Phenprocoumon — Overview · splits 92 ⟂ 12
Phenprocoumon — Adverse effects · splits 94 ⟂ 10
Phenprocoumon — Chemistry · splits 95 ⟂ 9
Phenprocoumon — Contraindications · splits 96 ⟂ 8
Phenprocoumon — Comparison with other anticoagulants · splits 98 ⟂ 6
Phenprocoumon — Overdose · splits 100 ⟂ 4
Phenprocoumon — History · splits 100 ⟂ 4

Map overview Semantic statistics

Phenprocoumon

Nodes104
Edges103
Triples88
Avg. degree1.98
Density0.019231
Components1

Source & methodology

TTTA analyzes the structure around Phenprocoumon to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Phenprocoumon · EN edition · Analysis: TopicsToTalkAbout

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