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G protein-coupled receptor

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses.…

History, Classification & Physiological roles

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Key facts & relationships

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AlphaFold
IPR000276 · PF00001
Available protein structures:
IPR000276 · PF00001
CDD
cd14964
ECOD
5001.1.1
InterPro
IPR000276
OPM protein
1gzm

Topics to explore

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Overview

History and significance

Classification

Physiological roles

Receptor structure

Structure–function relationships

Mechanism

Signaling

Details of cAMP and PIP2 pathways

Receptor regulation

Receptor oligomerization

Origin and diversification of the superfamily

Advanced semantic analysis

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Map overview Semantic statistics

G protein-coupled receptor

Nodes317
Edges316
Triples146
Avg. degree1.99
Density0.006309
Components1

How this topic connects Entity context

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G protein-coupled receptor

Top relations

related to External links · 51
G protein-coupled receptor → Application, April, Archived, August, Basic, Biology Network Center, British Journal, Clinical Pharmacology, Data, Edinburgh, February, G-protein, G-protein-coupled, GPCR, GPCR Cell Line Archived, GPCR-I-TASSER, GPCRdb, GPCRs, Harpsøe, Hauser AS
related to Further reading · 25
G protein-coupled receptor → America, April, Archived, August, Bibcode, Chemistry, GPCR Reference Library, Hohmann JG, Li, Mortrud MT, National Academy, October, PDF, PMC, PMID, Proceedings, Ranchalis JE, Reference, Retrieved, Sciences
related to Physiological roles · 24
G protein-coupled receptor → Adrenergic, AMPAR, Autonomic, Behavioral, Both, Cell, GABA, GABAA, GCPRs, GPCR, GPCRs, Homeostasis, HT3, Involved, NMDAR, Notable, Receptors, Regulation, Rhodopsin, Some
related to Phosphorylation by GRKs · 9
G protein-coupled receptor → Activity, G-protein-coupled, GPCR, GPCRs, GRKs, GRKs-mediated, Phosphorylation, The, They
related to Mechanism · 5
G protein-coupled receptor → Further, GTPase, RGS, The, This
see also · 5
G protein-coupled receptor → D12, GPCRsReceptor, GPCRsTOG, MeSH, Metabotropic
AlphaFold · 2
G protein-coupled receptor → IPR000276, PF00001
Available protein structures: · 2
G protein-coupled receptor → IPR000276, PF00001
CDD · 1
G protein-coupled receptor → cd14964
ECOD · 1
G protein-coupled receptor → 5001.1.1

Important terminology Word statistics

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Important terminology

receptor proteins gpcrs receptors gpcr protein also may signaling signal membrane structure g-protein camp ligand activated binding protein-coupled phosphorylation kinase

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
G protein-coupled receptorAlphaFoldIPR0002761.00infobox
G protein-coupled receptorAlphaFoldPF000011.00infobox
G protein-coupled receptorAvailable protein structures:IPR0002761.00infobox
G protein-coupled receptorAvailable protein structures:PF000011.00infobox
G protein-coupled receptorCDDcd149641.00infobox
G protein-coupled receptorECOD5001.1.11.00infobox
G protein-coupled receptorInterProIPR0002761.00infobox
G protein-coupled receptorOPM protein1gzm1.00infobox
G protein-coupled receptorOPM superfamily61.00infobox
G protein-coupled receptorPDBIPR000276 PF00001 (ECOD; PDBsum)1.00infobox
G protein-coupled receptorPfamPF000011.00infobox
G protein-coupled receptorPfam clanCL01921.00infobox
G protein-coupled receptorPROSITEPDOC002101.00infobox
G protein-coupled receptorSymbol7tm_11.00infobox
G protein-coupled receptorTCDB9.A.141.00infobox

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