Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

IL2RA: Expression, Signalling cascade of interleukin-2 receptor & Clinical significance

The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a pleiotropic cytokine which plays an…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

IL2RA topic overview

The analysis highlights Expression, Signalling cascade of interleukin-2 receptor and Clinical significance as prominent areas in the source structure around IL2RA.

Related topics
112
Source areas
6
Connected nodes
118
Extracted relationships
159
Concept neighborhoods
29
Bridge connections
118

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 39 topics
Signalling cascade of interleukin-2 receptor · 23 topics
Expression · 22 topics
Structure · 12 topics
Genetics · 9 topics
Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Band
10p15.1 · 2 A1|2 8.91 cM
Bgee
lymph node · appendix · spleen · buccal mucosa cell · gallbladder
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Genetics

Expression

Structure

Signalling cascade of interleukin-2 receptor

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How IL2RA connects Entity context

The extracted context around IL2RA shows recurring relationship patterns in the source. For example, IL2RA → activation-induced cell death of T cells, apoptotic process, cell population proliferation, cell surface, cell surface receptor signaling pathway, cytokine-mediated signaling pathway, external side of plasma membrane, immune response, immune system process, inflammatory response, inflammatory response to antigenic stimulus, integral component of membrane, interleukin-2 binding, interleukin-2 receptor activity, interleukin-2 receptor complex, interleukin-2-mediated signaling pathway, intracellular anatomical structure, MAPK cascade, membrane, negative regulation of defense response to virus Another extracted example is IL2RA → Also, C-terminus, CD122, CD132, CD25, Homodimeric, However, IL-15, IL-2, IL-21, IL-4, IL-7, IL-9, IL2, IL2RB, IL2RG, Interleukin-2, Kd, Moreover, N-terminus. Use these groups to spot repeated connection types before inspecting the individual relationships.

IL2RA

Top relations

Gene ontology · 34
IL2RA → activation-induced cell death of T cells, apoptotic process, cell population proliferation, cell surface, cell surface receptor signaling pathway, cytokine-mediated signaling pathway, external side of plasma membrane, immune response, immune system process, inflammatory response, inflammatory response to antigenic stimulus, integral component of membrane, interleukin-2 binding, interleukin-2 receptor activity, interleukin-2 receptor complex, interleukin-2-mediated signaling pathway, intracellular anatomical structure, MAPK cascade, membrane, negative regulation of defense response to virus
related to Structure · 23
IL2RA → Also, C-terminus, CD122, CD132, CD25, Homodimeric, However, IL-15, IL-2, IL-21, IL-4, IL-7, IL-9, IL2, IL2RB, IL2RG, Interleukin-2, Kd, Moreover, N-terminus
related to Expression · 18
IL2RA → Additionally, B-cell, CD25, CD4, CD8, FoxP3, High, However, IL-2, It, Kupffer, Langerhans, NK, T-cell, TCR, The, Tregs, Waldenstrom
Bgee · 17
IL2RA → appendix, blood, buccal mucosa cell, epithelium of colon, esophagus, gallbladder, granulocyte, lymph node, muscle of thigh, primary oocyte, secondary oocyte, smooth muscle tissue, spleen, sternocleidomastoid muscle, thymus, tonsil, zygote
RNA expression pattern · 17
IL2RA → appendix, blood, buccal mucosa cell, epithelium of colon, esophagus, gallbladder, granulocyte, lymph node, muscle of thigh, primary oocyte, secondary oocyte, smooth muscle tissue, spleen, sternocleidomastoid muscle, thymus, tonsil, zygote
related to CD25 as a therapeutic target · 16
IL2RA → Antibodies, Antibody, CD25, CD8, Fc, From, IL-2, IL-2Rα, Low-dose IL-2, Moreover, NARA1, Since Tregs, Therefore, This, Treg, Tregs
related to Genetics · 10
IL2RA → Alternative, IDDM10, IL2R, Location, MS, Several, SNP, TCGFR, The, These SNPs
Band · 2
IL2RA → 10p15.1, 2 A1|2 8.91 cM
Chr. · 2
IL2RA → Chromosome 10 (human), Chromosome 2 (mouse)
End · 2
IL2RA → 11,698,004 bp, 6,062,370 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor interleukin-2 cells cd25 protein gene human alpha il-2 subunit immune bp signalling 10 regulatory chr band expression levels also

IL2RA relationships Subject–Predicate–Object triples

TTTA extracted 159 structured relationships around IL2RA. Examples in this analysis include IL2RA → Aliases → IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha and IL2RA → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z92, 2B5I, 2ERJ, 3IU3, 3NFP. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
IL2RAAliasesIL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha1.00infobox
IL2RAAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z92, 2B5I, 2ERJ, 3IU3, 3NFP1.00infobox
IL2RABand10p15.11.00infobox
IL2RABand2 A1|2 8.91 cM1.00infobox
IL2RABgeelymph node1.00infobox
IL2RABgeeappendix1.00infobox
IL2RABgeespleen1.00infobox
IL2RABgeebuccal mucosa cell1.00infobox
IL2RABgeegallbladder1.00infobox
IL2RABgeeblood1.00infobox
IL2RABgeegranulocyte1.00infobox
IL2RABgeeepithelium of colon1.00infobox
IL2RABgeesmooth muscle tissue1.00infobox
IL2RABgeetonsil1.00infobox
IL2RABgeethymus1.00infobox
IL2RABgeezygote1.00infobox
IL2RABgeesecondary oocyte1.00infobox
IL2RABgeemuscle of thigh1.00infobox
IL2RABgeeprimary oocyte1.00infobox
IL2RABgeesternocleidomastoid muscle1.00infobox
IL2RABgeeesophagus1.00infobox
IL2RABioGPSMore reference expression data1.00infobox
IL2RAChr.Chromosome 10 (human)1.00infobox
IL2RAChr.Chromosome 2 (mouse)1.00infobox
IL2RADatabasesNCBI: entry; OMA: entry1.00infobox
IL2RAEnd6,062,370 bp1.00infobox
IL2RAEnd11,698,004 bp1.00infobox
IL2RAEnsemblENSG000001344601.00infobox
IL2RAEntrez35591.00infobox
IL2RAExternal IDsOMIM: 147730; MGI: 96549; GeneCards: IL2RA1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around IL2RA bring nearby vocabulary together. In this analysis, examples include Receptor, Gene and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • IL2RA
    • Receptor
    • Gene
    • Protein
    • Il2rb
    • Il2rg
    • Location
    • Interleukin-2
    • Chromosome
    • Beta
    • Gamma
    • Human
    • Cells
  • il2ra
    • Receptor
    • Gene
    • Protein
    • Il2rb
    • Il2rg
    • Location
    • Interleukin-2
    • Chromosome
    • Beta
    • Gamma
    • Human
    • Cells
  • interleukin-2 receptor
    • Receptor
    • Alpha
    • Subunit
    • High-affinity
    • Il-2
    • Beta
    • Gamma
    • Human
    • Il2ra
    • External
    • Immune
    • Protein
  • interleukin-2
    • Receptor
    • Alpha
    • High-affinity
    • Subunit
    • Beta
    • Gamma
    • Human
    • Il2ra
    • External
    • Il-2
    • Immune
    • Protein
  • regulatory t cells
    • Regulatory
    • Cd4
    • Lymphocytes
    • Expressed
    • Expression
    • Il2ra
    • Protein
    • Subunit
    • Interleukin-2
    • Receptor
    • Mouse
    • Used
  • b cells
    • Regulatory
    • Cd4
    • Lymphocytes
    • Expressed
    • Expression
    • Il2ra
    • Protein
    • Subunit
    • Interleukin-2
    • Receptor
    • Mouse
    • Used
  • nk (natural killer) cells
    • Regulatory
    • Cd4
    • Lymphocytes
    • Expressed
    • Expression
    • Il2ra
    • Protein
    • Subunit
    • Interleukin-2
    • Receptor
    • Mouse
    • Used
  • dendritic cells
    • Regulatory
    • Cd4
    • Lymphocytes
    • Expressed
    • Expression
    • Il2ra
    • Protein
    • Subunit
    • Interleukin-2
    • Receptor
    • Mouse
    • Used

Connections between topic areas Semantic bridges

For IL2RA, one of the stronger structural bridges in this analysis connects IL2RA with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IL2RAClinical significance · splits 79 ⟂ 40
IL2RASignalling cascade of interleukin-2 receptor · splits 95 ⟂ 24
IL2RAExpression · splits 96 ⟂ 23
IL2RAStructure · splits 106 ⟂ 13
IL2RAGenetics · splits 109 ⟂ 10
IL2RAOverview · splits 111 ⟂ 8

Map overview Semantic statistics

IL2RA

Nodes119
Edges118
Triples159
Avg. degree1.98
Density0.016807
Components1

Source & methodology

TTTA analyzes the structure around IL2RA to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Expression, Signalling cascade of interleukin-2 receptor & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — IL2RA · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.