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IL2RA

The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a pleiotropic cytokine which plays an…

Expression, Signalling cascade of interleukin-2 receptor & Clinical significance

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Aliases
IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Band
10p15.1 · 2 A1|2 8.91 cM
Bgee
lymph node · appendix · spleen · buccal mucosa cell · gallbladder
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 2 (mouse)

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Overview

Genetics

Expression

Structure

Signalling cascade of interleukin-2 receptor

Clinical significance

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Map overview Semantic statistics

IL2RA

Nodes119
Edges118
Triples159
Avg. degree1.98
Density0.016807
Components1

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IL2RA

Top relations

Gene ontology · 34
IL2RA → activation-induced cell death of T cells, apoptotic process, cell population proliferation, cell surface, cell surface receptor signaling pathway, cytokine-mediated signaling pathway, external side of plasma membrane, immune response, immune system process, inflammatory response, inflammatory response to antigenic stimulus, integral component of membrane, interleukin-2 binding, interleukin-2 receptor activity, interleukin-2 receptor complex, interleukin-2-mediated signaling pathway, intracellular anatomical structure, MAPK cascade, membrane, negative regulation of defense response to virus
related to Structure · 23
IL2RA → Also, C-terminus, CD122, CD132, CD25, Homodimeric, However, IL-15, IL-2, IL-21, IL-4, IL-7, IL-9, IL2, IL2RB, IL2RG, Interleukin-2, Kd, Moreover, N-terminus
related to Expression · 18
IL2RA → Additionally, B-cell, CD25, CD4, CD8, FoxP3, High, However, IL-2, It, Kupffer, Langerhans, NK, T-cell, TCR, The, Tregs, Waldenstrom
Bgee · 17
IL2RA → appendix, blood, buccal mucosa cell, epithelium of colon, esophagus, gallbladder, granulocyte, lymph node, muscle of thigh, primary oocyte, secondary oocyte, smooth muscle tissue, spleen, sternocleidomastoid muscle, thymus, tonsil, zygote
RNA expression pattern · 17
IL2RA → appendix, blood, buccal mucosa cell, epithelium of colon, esophagus, gallbladder, granulocyte, lymph node, muscle of thigh, primary oocyte, secondary oocyte, smooth muscle tissue, spleen, sternocleidomastoid muscle, thymus, tonsil, zygote
related to CD25 as a therapeutic target · 16
IL2RA → Antibodies, Antibody, CD25, CD8, Fc, From, IL-2, IL-2Rα, Low-dose IL-2, Moreover, NARA1, Since Tregs, Therefore, This, Treg, Tregs
related to Genetics · 10
IL2RA → Alternative, IDDM10, IL2R, Location, MS, Several, SNP, TCGFR, The, These SNPs
Band · 2
IL2RA → 10p15.1, 2 A1|2 8.91 cM
Chr. · 2
IL2RA → Chromosome 10 (human), Chromosome 2 (mouse)
End · 2
IL2RA → 11,698,004 bp, 6,062,370 bp

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Important terminology

receptor interleukin-2 cells cd25 protein gene human alpha il-2 subunit immune bp signalling 10 regulatory chr band expression levels also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IL2RAAliasesIL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha1.00infobox
IL2RAAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Z92, 2B5I, 2ERJ, 3IU3, 3NFP1.00infobox
IL2RABand10p15.11.00infobox
IL2RABand2 A1|2 8.91 cM1.00infobox
IL2RABgeelymph node1.00infobox
IL2RABgeeappendix1.00infobox
IL2RABgeespleen1.00infobox
IL2RABgeebuccal mucosa cell1.00infobox
IL2RABgeegallbladder1.00infobox
IL2RABgeeblood1.00infobox
IL2RABgeegranulocyte1.00infobox
IL2RABgeeepithelium of colon1.00infobox
IL2RABgeesmooth muscle tissue1.00infobox
IL2RABgeetonsil1.00infobox
IL2RABgeethymus1.00infobox
IL2RABgeezygote1.00infobox
IL2RABgeesecondary oocyte1.00infobox
IL2RABgeemuscle of thigh1.00infobox
IL2RABgeeprimary oocyte1.00infobox
IL2RABgeesternocleidomastoid muscle1.00infobox
IL2RABgeeesophagus1.00infobox
IL2RABioGPSMore reference expression data1.00infobox
IL2RAChr.Chromosome 10 (human)1.00infobox
IL2RAChr.Chromosome 2 (mouse)1.00infobox
IL2RADatabasesNCBI: entry; OMA: entry1.00infobox
IL2RAEnd6,062,370 bp1.00infobox
IL2RAEnd11,698,004 bp1.00infobox
IL2RAEnsemblENSG000001344601.00infobox
IL2RAEntrez35591.00infobox
IL2RAExternal IDsOMIM: 147730; MGI: 96549; GeneCards: IL2RA1.00infobox

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