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Peripheral tolerance

In immunology, peripheral tolerance is the second branch of immunological tolerance, after central tolerance. It takes place in lymph nodes and tissues other than the thymus and bone marrow (after T and B cells egress from primary lymphoid organs). Its main purpose is to ensure that self-reactive T and B cells which escaped central tolerance do not cause…

Cells mediating peripheral tolerance, Overview & Intrinsic mechanisms of T cell peripheral tolerance

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Cells mediating peripheral tolerance

Foxp3Negative selectionTCRTGF-βIL-2
31 related topics

Overview

ImmunologyImmunological toleranceCentral toleranceLymph nodesThymus
22 related topics

Intrinsic mechanisms of T cell peripheral tolerance

Cell cycleDownregulationImmune privileged organsNFATMAPK
10 related topics

Immunoprivileged organs

Tight junctions
1 related topics

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Overview

Cells mediating peripheral tolerance

Intrinsic mechanisms of T cell peripheral tolerance

Immunoprivileged organs

Split tolerance

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Peripheral tolerance

Nodes71
Edges70
Triples39
Avg. degree1.97
Density0.028169
Components1

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Peripheral tolerance

Top relations

related to LNSCs · 20
Peripheral tolerance → Among, Aside, Both, CD31, CD4, CD8, DCs, Deaf1, In, LECs, LNSCs, MHCI, MHCII, On, PD-1, PD-L1, PDPN, TGF-β, These, Tregs
related to Regulatory T cells · 15
Peripheral tolerance → CD28-mediated, CTLA-4, Foxp3, IL-10, IL-2, IL-35, Induced Tregs, Natural Tregs, Regardless, TCR, TGF-β, The, These, Treg, Tregs
is a · 1
Peripheral tolerance → second branch of immunological tolerance

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Important terminology

cells cell tolerance peripheral antigen immune self-reactive mechanisms dcs response deletion autoimmune thymus naive tregs central also ignorance antigens state

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Peripheral toleranceis asecond branch of immunological tolerance0.90text
the eyesinstance ofImmunopathogenic disturbances are not present in a variety of specialized organs0.80text
reproductive organsinstance ofImmunopathogenic disturbances are not present in a variety of specialized organs0.80text
and the central nervous systeminstance ofImmunopathogenic disturbances are not present in a variety of specialized organs0.80text
Peripheral tolerancerelated to LNSCsAside0.60section
Peripheral tolerancerelated to LNSCsThese0.60section
Peripheral tolerancerelated to LNSCsLNSCs0.60section
Peripheral tolerancerelated to LNSCsPDPN0.60section
Peripheral tolerancerelated to LNSCsCD310.60section
Peripheral tolerancerelated to LNSCsAmong0.60section
Peripheral tolerancerelated to LNSCsLECs0.60section
Peripheral tolerancerelated to LNSCsBoth0.60section

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    Min side: 3
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