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TNFRSF18: Standards & Products
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced TNFR-related protein (GITR) or CD357. GITR is encoded and tnfrsf18 gene at chromosome 4 in mice. GITR is type I transmembrane protein and is described in 4 different isoforms. GITR human orthologue, also called activation-inducible TNFR family receptor…
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TNFRSF18 topic overview
The analysis highlights Standards and Products as prominent areas in the source structure around TNFRSF18.
Related topics
2
Source areas
2
Connected nodes
4
Extracted relationships
80
Concept neighborhoods
5
Bridge connections
4
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 1 topics
Tissue distribution · 1 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Aliases
TNFRSF18, AITR, CD357, GITR, GITR-D, tumor necrosis factor receptor superfamily member 18, TNF receptor superfamily member 18, ENERGEN
Band
1p36.33 · 4|4 E2
Bgee
skin of abdomen · granulocyte · skin of leg · cartilage tissue · nasal epithelium
BioGPS
n/a
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)
Databases
NCBI: entry; OMA: entry
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How TNFRSF18 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around TNFRSF18 shows recurring relationship patterns in the source. For example, TNFRSF18 → apoptotic process, apoptotic signaling pathway, extracellular region, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, multicellular organism development, negative regulation of apoptotic process, plasma membrane, positive regulation of cell adhesion, positive regulation of leukocyte migration, positive regulation of tyrosine phosphorylation of STAT protein, protein binding, regulation of apoptotic process, regulation of cell population proliferation, regulation of regulatory T cell differentiation, response to lipopolysaccharide, signal transduction Another extracted example is TNFRSF18 → blood, cartilage tissue, genital tubercle, granulocyte, lip, mesenteric lymph nodes, mucosa of transverse colon, nasal epithelium, neural layer of retina, olfactory zone of nasal mucosa, skin of abdomen, skin of arm, skin of leg, spleen, tail of embryo, testicle, thymus, tibialis anterior muscle, zone of skin. Use these groups to spot repeated connection types before inspecting the individual relationships.
TNFRSF18
Top relations
Gene ontology· 22
TNFRSF18 → apoptotic process, apoptotic signaling pathway, extracellular region, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, multicellular organism development, negative regulation of apoptotic process, plasma membrane, positive regulation of cell adhesion, positive regulation of leukocyte migration, positive regulation of tyrosine phosphorylation of STAT protein, protein binding, regulation of apoptotic process, regulation of cell population proliferation, regulation of regulatory T cell differentiation, response to lipopolysaccharide, signal transduction
Bgee· 19
TNFRSF18 → blood, cartilage tissue, genital tubercle, granulocyte, lip, mesenteric lymph nodes, mucosa of transverse colon, nasal epithelium, neural layer of retina, olfactory zone of nasal mucosa, skin of abdomen, skin of arm, skin of leg, spleen, tail of embryo, testicle, thymus, tibialis anterior muscle, zone of skin
RNA expression pattern· 19
TNFRSF18 → blood, cartilage tissue, genital tubercle, granulocyte, lip, mesenteric lymph nodes, mucosa of transverse colon, nasal epithelium, neural layer of retina, olfactory zone of nasal mucosa, skin of abdomen, skin of arm, skin of leg, spleen, tail of embryo, testicle, thymus, tibialis anterior muscle, zone of skin
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 80 structured relationships around TNFRSF18. Examples in this analysis include TNFRSF18 → Aliases → TNFRSF18, AITR, CD357, GITR, GITR-D, tumor necrosis factor receptor superfamily member 18, TNF receptor superfamily member 18, ENERGEN and TNFRSF18 → Band → 1p36.33. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
TNFRSF18
Aliases
TNFRSF18, AITR, CD357, GITR, GITR-D, tumor necrosis factor receptor superfamily member 18, TNF receptor superfamily member 18, ENERGEN
1.00
infobox
TNFRSF18
Band
1p36.33
1.00
infobox
TNFRSF18
Band
4|4 E2
1.00
infobox
TNFRSF18
Bgee
skin of abdomen
1.00
infobox
TNFRSF18
Bgee
granulocyte
1.00
infobox
TNFRSF18
Bgee
skin of leg
1.00
infobox
TNFRSF18
Bgee
cartilage tissue
1.00
infobox
TNFRSF18
Bgee
nasal epithelium
1.00
infobox
TNFRSF18
Bgee
testicle
1.00
infobox
TNFRSF18
Bgee
skin of arm
1.00
infobox
TNFRSF18
Bgee
olfactory zone of nasal mucosa
1.00
infobox
TNFRSF18
Bgee
tibialis anterior muscle
1.00
infobox
TNFRSF18
Bgee
mucosa of transverse colon
1.00
infobox
TNFRSF18
Bgee
neural layer of retina
1.00
infobox
TNFRSF18
Bgee
thymus
1.00
infobox
TNFRSF18
Bgee
blood
1.00
infobox
TNFRSF18
Bgee
lip
1.00
infobox
TNFRSF18
Bgee
genital tubercle
1.00
infobox
TNFRSF18
Bgee
spleen
1.00
infobox
TNFRSF18
Bgee
tail of embryo
1.00
infobox
TNFRSF18
Bgee
mesenteric lymph nodes
1.00
infobox
TNFRSF18
Bgee
zone of skin
1.00
infobox
TNFRSF18
BioGPS
n/a
1.00
infobox
TNFRSF18
Chr.
Chromosome 1 (human)
1.00
infobox
TNFRSF18
Chr.
Chromosome 4 (mouse)
1.00
infobox
TNFRSF18
Databases
NCBI: entry; OMA: entry
1.00
infobox
TNFRSF18
End
1,206,592 bp
1.00
infobox
TNFRSF18
End
156,113,352 bp
1.00
infobox
TNFRSF18
Ensembl
ENSG00000186891
1.00
infobox
TNFRSF18
Entrez
8784
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around TNFRSF18 bring nearby vocabulary together. In this analysis, examples include Chromosome, Gene and Tumor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
TNFRSF18
Chromosome
Gene
Tumor
Encoded
Human
Aitr
Function
Location
Tissue
Protein
Bp
Chr
tnfrsf18
Chromosome
Gene
Tumor
Encoded
Human
Aitr
Function
Location
Tissue
Protein
Bp
Chr
type i transmembrane protein
Tissue
Tumor
Tnfrsf18
Expression
Receptor
Mouse
Function
Location
Pathway
Plasma
Band
Cd4
cd4
Expressed
Regulatory
Cells
Mouse
Function
Location
Pathway
Plasma
Signaling
Tissue
Cell
Gitr
tissue distribution
Location
Tumor
Bp
Chr
Tnfrsf18
Expression
Mouse
Pathway
Plasma
Band
Cd4
Cell
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
Bridges highlight paths between different parts of the TNFRSF18 map and can reveal research angles that are easy to miss in a flat list.
Min side: 3
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
TNFRSF18
Nodes5
Edges4
Triples80
Avg. degree1.6
Density0.4
Components1
Source & methodology
TTTA analyzes the structure around TNFRSF18 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
