Programmed cell death protein 1

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

Programmed cell death protein 1 topic overview

The analysis highlights Research, Clinical significance and Structure as prominent areas in the source structure around Programmed cell death protein 1.

Related topics: 75
Source areas: 7
Connected nodes: 82
Extracted relationships: 86
Concept neighborhoods: 27
Bridge connections: 82

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 19 topics

Overview · 19 topics

Structure · 14 topics

Function · 12 topics

Ligands · 7 topics

Animal studies · 2 topics

Discovery · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M2D, 3RRQ, 4ZQK
Band: 2q37.3 · 1|1 D
Bgee: lymph node · granulocyte · spleen · right auricle of heart · appendix
BioGPS: More reference expression data
Chr.: Chromosome 2 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Structure

Type I membrane protein
Amino acids Amino acid
CD28
CTLA-4
Transmembrane
Phosphorylation
Immunoreceptor tyrosine-based inhibitory motif
TCR T-cell receptor
SHP-1 PTPN6
SHP-2 PTPN11
Phosphatases Protein phosphatase
E3 ubiquitin ligases E3 ubiquitin ligase
CBL-b CBL (gene)
Macrophages Macrophage

Ligands

B7 B7 (protein)
Dendritic cells Dendritic cell
LPS Lipopolysaccharide
GM-CSF Granulocyte macrophage colony-stimulating factor
MRNA
B16 melanoma
IFN-γ Interferon-gamma

Function

Clinical significance

Monoclonal antibodies
Cancer
Immune checkpoint blockade
Checkpoint inhibition
Ipilimumab
Nivolumab
Nobel Prize for Medicine
James P Allison James P. Allison
Bristol Myers Squibb
Melanoma
Pembrolizumab
Toripalimab
Checkpoint inhibitors Checkpoint inhibitor
Pidilizumab
BMS-936559 BMS-936559?action=edit&redlink=1
Atezolizumab
Avelumab
Merck KGaA, Darmstadt, Germany Merck KGaA
Pfizer

Animal studies

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Programmed cell death protein 1 connects Entity context

The extracted context around Programmed cell death protein 1 shows recurring relationship patterns in the source. For example, Programmed cell death protein 1 → appendix, blood, cumulus cell, embryo, granulocyte, left ventricle, lymph node, mesenteric lymph nodes, mucosa of transverse colon, ovary, primary oocyte, right auricle of heart, spleen, thymus, tonsil, upper lobe of left lung, zygote Another extracted example is Programmed cell death protein 1 → apoptotic process, external side of plasma membrane, humoral immune response, immune system process, integral component of membrane, membrane, multicellular organism development, negative regulation of apoptotic process, negative regulation of tolerance induction, plasma membrane, positive regulation of apoptotic process, positive regulation of T cell apoptotic process, protein binding, signal transducer activity, signal transduction, T cell costimulation. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Bgee · 17

Programmed cell death protein 1 → appendix, blood, cumulus cell, embryo, granulocyte, left ventricle, lymph node, mesenteric lymph nodes, mucosa of transverse colon, ovary, primary oocyte, right auricle of heart, spleen, thymus, tonsil, upper lobe of left lung, zygote

RNA expression pattern · 17

Gene ontology · 16

Programmed cell death protein 1 → apoptotic process, external side of plasma membrane, humoral immune response, immune system process, integral component of membrane, membrane, multicellular organism development, negative regulation of apoptotic process, negative regulation of tolerance induction, plasma membrane, positive regulation of apoptotic process, positive regulation of T cell apoptotic process, protein binding, signal transducer activity, signal transduction, T cell costimulation

related to External links · 13

Programmed cell death protein 1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, PDCD1, Programmed, Q15116, This, UniProt, United States National Library

Band · 2

Programmed cell death protein 1 → 1|1 D, 2q37.3

Chr. · 2

Programmed cell death protein 1 → Chromosome 1 (mouse), Chromosome 2 (human)

End · 2

Programmed cell death protein 1 → 241,858,894 bp, 93,980,278 bp

Aliases · 1

Programmed cell death protein 1 → PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1

Available structures · 1

Programmed cell death protein 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M2D, 3RRQ, 4ZQK

BioGPS · 1

Programmed cell death protein 1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pd-1 cell immune cancer pd-l1 cells tumor treatment gene human expressed system melanoma receptor bp expression response responses protein activity

Programmed cell death protein 1 relationships Subject–Predicate–Object triples

TTTA extracted 86 structured relationships around Programmed cell death protein 1. Examples in this analysis include Programmed cell death protein 1 → Aliases → PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1 and Programmed cell death protein 1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M2D, 3RRQ, 4ZQK. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Programmed cell death protein 1	Aliases	PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1	1.00	infobox
Programmed cell death protein 1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M2D, 3RRQ, 4ZQK	1.00	infobox
Programmed cell death protein 1	Band	2q37.3	1.00	infobox
Programmed cell death protein 1	Band	1\|1 D	1.00	infobox
Programmed cell death protein 1	Bgee	lymph node	1.00	infobox
Programmed cell death protein 1	Bgee	granulocyte	1.00	infobox
Programmed cell death protein 1	Bgee	spleen	1.00	infobox
Programmed cell death protein 1	Bgee	right auricle of heart	1.00	infobox
Programmed cell death protein 1	Bgee	appendix	1.00	infobox
Programmed cell death protein 1	Bgee	blood	1.00	infobox
Programmed cell death protein 1	Bgee	left ventricle	1.00	infobox
Programmed cell death protein 1	Bgee	mucosa of transverse colon	1.00	infobox
Programmed cell death protein 1	Bgee	upper lobe of left lung	1.00	infobox
Programmed cell death protein 1	Bgee	tonsil	1.00	infobox
Programmed cell death protein 1	Bgee	embryo	1.00	infobox
Programmed cell death protein 1	Bgee	thymus	1.00	infobox
Programmed cell death protein 1	Bgee	mesenteric lymph nodes	1.00	infobox
Programmed cell death protein 1	Bgee	zygote	1.00	infobox
Programmed cell death protein 1	Bgee	cumulus cell	1.00	infobox
Programmed cell death protein 1	Bgee	primary oocyte	1.00	infobox
Programmed cell death protein 1	Bgee	ovary	1.00	infobox
Programmed cell death protein 1	BioGPS	More reference expression data	1.00	infobox
Programmed cell death protein 1	Chr.	Chromosome 2 (human)	1.00	infobox
Programmed cell death protein 1	Chr.	Chromosome 1 (mouse)	1.00	infobox
Programmed cell death protein 1	Databases	NCBI: entry; OMA: entry	1.00	infobox
Programmed cell death protein 1	End	241,858,894 bp	1.00	infobox
Programmed cell death protein 1	End	93,980,278 bp	1.00	infobox
Programmed cell death protein 1	Ensembl	ENSG00000188389 ENSG00000276977	1.00	infobox
Programmed cell death protein 1	Entrez	5133	1.00	infobox
Programmed cell death protein 1	External IDs	OMIM: 600244; MGI: 104879; GeneCards: PDCD1	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Programmed cell death protein 1 bring nearby vocabulary together. In this analysis, examples include Pdcd1, Protein and Cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Programmed cell death protein 1
- Pdcd1
- Protein
- Cells
- Gene
- Death
- Programmed
- Cd8
- Receptor
- Apoptosis
- Chromosome
- Ligands
- Treatment
programmed cell death protein 1
- Programmed
- Pdcd1
- Protein
- Cells
- Gene
- Pd-1
- Death
- Response
- Cd8
- Receptor
- Apoptosis
- Chromosome
gene
- Chromosome
- Pdcd1
- Bp
- Chr
- Human
- Apoptosis
- Band
- Programmed
- Mice
- Protein
- Expression
- Ligands
cell surface receptor
- Cells
- Surface
- Expressed
- Pd-1
- Death
- Programmed
- Protein
- Cd8
- Receptor
- Response
- Gene
- Treatment
t cell
- Cells
- Pd-1
- Death
- Programmed
- Protein
- Cd8
- Receptor
- Gene
- Treatment
- Pdcd1
- Activity
- Anti-pd-1
immune system
- Pd-1
- System
- Cancer
- Expressed
- Responses
- Checkpoint
- Activity
- Response
- Surface
- Human
- Treatment
- Tumor
immune checkpoint
- Pd-1
- System
- Cancer
- Combination
- Expressed
- Responses
- Checkpoint
- Immune
- Activity
- Response
- Two
- Therapy
pd-1 inhibitors
- Immune
- Pd-l1
- Expressed
- Responses
- Activity
- System
- Cells
- Receptor
- Ligands
- Cancer
- Two
- Gene

Connections between topic areas Semantic bridges

For Programmed cell death protein 1, one of the stronger structural bridges in this analysis connects Programmed cell death protein 1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Programmed cell death protein 1 — Overview · splits 63 ⟂ 20

Programmed cell death protein 1 — Clinical significance · splits 63 ⟂ 20

Programmed cell death protein 1 — Structure · splits 68 ⟂ 15

Programmed cell death protein 1 — Function · splits 70 ⟂ 13

Programmed cell death protein 1 — Ligands · splits 75 ⟂ 8

Programmed cell death protein 1 — Discovery · splits 80 ⟂ 3

Programmed cell death protein 1 — Animal studies · splits 80 ⟂ 3

Map overview Semantic statistics

Programmed cell death protein 1

Nodes83

Edges82

Triples86

Avg. degree1.98

Density0.024096

Components1

Source & methodology

TTTA analyzes the structure around Programmed cell death protein 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Programmed cell death protein 1 · EN edition · Analysis: TopicsToTalkAbout