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Thymic stromal lymphopoietin: Gene, Function & Overview

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine, alarmin, and growth factor involved in numerous physiological and pathological processes, primarily those of the immune system. It shares a common ancestor with IL-7.

Language: English [EN]
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Thymic stromal lymphopoietin topic overview

The analysis highlights Gene, Function and Overview as prominent areas in the source structure around Thymic stromal lymphopoietin.

Related topics
104
Source areas
5
Connected nodes
109
Extracted relationships
97
Concept neighborhoods
40
Bridge connections
109

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 59 topics
Gene · 19 topics
Function · 13 topics
Clinical significance · 7 topics
Discovery · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TSLP, thymic stromal lymphopoietin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NN5, 4NN6, 4NN7
Band
5q22.1 · 18 B1|18 18.12 cM
Bgee
pancreatic epithelial cell · gallbladder · cartilage tissue · right lobe of liver · right ventricle
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Gene

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Thymic stromal lymphopoietin connects Entity context

The extracted context around Thymic stromal lymphopoietin shows recurring relationship patterns in the source. For example, Thymic stromal lymphopoietin → antimicrobial humoral immune response mediated by antimicrobial peptide, cytokine activity, defense response to fungus, defense response to Gram-negative bacterium, extracellular region, extracellular space, interleukin-7 receptor binding, interleukin-7-mediated signaling pathway, negative regulation of apoptotic process, positive regulation of cell population proliferation, positive regulation of chemokine (C-C motif) ligand 1 production, positive regulation of chemokine production, positive regulation of cytokine-mediated signaling pathway, positive regulation of granulocyte colony-stimulating factor production, positive regulation of inflammatory response, positive regulation of interleukin-10 production, positive regulation of interleukin-13 production, positive regulation of interleukin-5 production, positive regulation of interleukin-6 production, positive regulation of mast cell activation Another extracted example is Thymic stromal lymphopoietin → apex of heart, atrioventricular valve, cartilage tissue, embryo, endothelial cell of lymphatic vessel, gallbladder, left lung lobe, myocardium of left ventricle, pancreatic epithelial cell, Paneth cell, prostate, right coronary artery, right lobe of liver, right lung, right lung lobe, right ventricle, secondary oocyte, urinary bladder, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Thymic stromal lymphopoietin

Top relations

Gene ontology · 23
Thymic stromal lymphopoietin → antimicrobial humoral immune response mediated by antimicrobial peptide, cytokine activity, defense response to fungus, defense response to Gram-negative bacterium, extracellular region, extracellular space, interleukin-7 receptor binding, interleukin-7-mediated signaling pathway, negative regulation of apoptotic process, positive regulation of cell population proliferation, positive regulation of chemokine (C-C motif) ligand 1 production, positive regulation of chemokine production, positive regulation of cytokine-mediated signaling pathway, positive regulation of granulocyte colony-stimulating factor production, positive regulation of inflammatory response, positive regulation of interleukin-10 production, positive regulation of interleukin-13 production, positive regulation of interleukin-5 production, positive regulation of interleukin-6 production, positive regulation of mast cell activation
Bgee · 19
Thymic stromal lymphopoietin → apex of heart, atrioventricular valve, cartilage tissue, embryo, endothelial cell of lymphatic vessel, gallbladder, left lung lobe, myocardium of left ventricle, pancreatic epithelial cell, Paneth cell, prostate, right coronary artery, right lobe of liver, right lung, right lung lobe, right ventricle, secondary oocyte, urinary bladder, zygote
RNA expression pattern · 19
Thymic stromal lymphopoietin → apex of heart, atrioventricular valve, cartilage tissue, embryo, endothelial cell of lymphatic vessel, gallbladder, left lung lobe, myocardium of left ventricle, pancreatic epithelial cell, Paneth cell, prostate, right coronary artery, right lobe of liver, right lung, right lung lobe, right ventricle, secondary oocyte, urinary bladder, zygote
related to External links · 6
Thymic stromal lymphopoietin → Overview, PDB, PDBe-KB, Q969D9, Thymic, UniProt
Band · 2
Thymic stromal lymphopoietin → 18 B1|18 18.12 cM, 5q22.1
Chr. · 2
Thymic stromal lymphopoietin → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
Thymic stromal lymphopoietin → 111,078,026 bp, 32,952,850 bp
Aliases · 1
Thymic stromal lymphopoietin → TSLP, thymic stromal lymphopoietin
Available structures · 1
Thymic stromal lymphopoietin → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NN5, 4NN6, 4NN7
BioGPS · 1
Thymic stromal lymphopoietin → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tslp cells immune human bp sftslp stromal alarmin chr gene band responses epithelial mrna expression receptor cell pro-inflammatory thymic mouse

Thymic stromal lymphopoietin relationships Subject–Predicate–Object triples

TTTA extracted 97 structured relationships around Thymic stromal lymphopoietin. Examples in this analysis include Thymic stromal lymphopoietin → Aliases → TSLP, thymic stromal lymphopoietin and Thymic stromal lymphopoietin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NN5, 4NN6, 4NN7. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Thymic stromal lymphopoietinAliasesTSLP, thymic stromal lymphopoietin1.00infobox
Thymic stromal lymphopoietinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NN5, 4NN6, 4NN71.00infobox
Thymic stromal lymphopoietinBand5q22.11.00infobox
Thymic stromal lymphopoietinBand18 B1|18 18.12 cM1.00infobox
Thymic stromal lymphopoietinBgeepancreatic epithelial cell1.00infobox
Thymic stromal lymphopoietinBgeegallbladder1.00infobox
Thymic stromal lymphopoietinBgeecartilage tissue1.00infobox
Thymic stromal lymphopoietinBgeeright lobe of liver1.00infobox
Thymic stromal lymphopoietinBgeeright ventricle1.00infobox
Thymic stromal lymphopoietinBgeemyocardium of left ventricle1.00infobox
Thymic stromal lymphopoietinBgeeapex of heart1.00infobox
Thymic stromal lymphopoietinBgeeurinary bladder1.00infobox
Thymic stromal lymphopoietinBgeeprostate1.00infobox
Thymic stromal lymphopoietinBgeeright coronary artery1.00infobox
Thymic stromal lymphopoietinBgeeembryo1.00infobox
Thymic stromal lymphopoietinBgeeleft lung lobe1.00infobox
Thymic stromal lymphopoietinBgeeendothelial cell of lymphatic vessel1.00infobox
Thymic stromal lymphopoietinBgeezygote1.00infobox
Thymic stromal lymphopoietinBgeePaneth cell1.00infobox
Thymic stromal lymphopoietinBgeeright lung1.00infobox
Thymic stromal lymphopoietinBgeeright lung lobe1.00infobox
Thymic stromal lymphopoietinBgeesecondary oocyte1.00infobox
Thymic stromal lymphopoietinBgeeatrioventricular valve1.00infobox
Thymic stromal lymphopoietinBioGPSn/a1.00infobox
Thymic stromal lymphopoietinChr.Chromosome 5 (human)1.00infobox
Thymic stromal lymphopoietinChr.Chromosome 18 (mouse)1.00infobox
Thymic stromal lymphopoietinDatabasesNCBI: entry; OMA: entry1.00infobox
Thymic stromal lymphopoietinEnd111,078,026 bp1.00infobox
Thymic stromal lymphopoietinEnd32,952,850 bp1.00infobox
Thymic stromal lymphopoietinEnsemblENSG000001457771.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Thymic stromal lymphopoietin bring nearby vocabulary together. In this analysis, examples include Thymic, Lymphopoietin and Stromal. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Thymic stromal lymphopoietin
    • Thymic
    • Lymphopoietin
    • Stromal
    • Factor
    • Location
    • Chromosome
    • Gene
    • Bp
    • Chr
    • Human
    • Immune
    • Mouse
  • thymic stromal lymphopoietin
    • Thymic
    • Lymphopoietin
    • Stromal
    • Factor
    • Location
    • Chromosome
    • Gene
    • Activation
    • Bp
    • Cell
    • Chr
    • Immune
  • growth factor
    • Expressed
    • Thymic
    • Stromal
    • Immune
    • Location
    • Lymphopoietin
    • Mouse
    • Proliferation
    • Activation
    • Band
    • Cell
    • Chromosome
  • immune system
    • Responses
    • Cell
    • Role
    • Type
    • Stromal
    • Proliferation
    • Activation
    • Certain
    • Dcs
    • Thymic
    • Cells
    • Epithelial
  • immune cell
    • Responses
    • Proliferation
    • Activation
    • Certain
    • Role
    • Cell
    • Immune
    • Type
    • Epithelial
    • Stromal
    • Receptor
    • Dcs
  • proliferation
    • Location
    • Mouse
    • Activation
    • Band
    • Certain
    • Chromosome
    • Dcs
    • Expressed
    • Gene
    • Inflammatory
    • Mrna
    • Role
  • type 2 immune responses
    • Responses
    • Role
    • Type
    • Dcs
    • Cell
    • Immune
    • Stromal
    • Certain
    • Cells
    • Proliferation
    • Activation
    • Thymic
  • immune responses
    • Responses
    • Role
    • Type
    • Cell
    • Stromal
    • Certain
    • Dcs
    • Cells
    • Proliferation
    • Activation
    • Thymic
    • Epithelial

Connections between topic areas Semantic bridges

For Thymic stromal lymphopoietin, one of the stronger structural bridges in this analysis connects Thymic stromal lymphopoietin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Thymic stromal lymphopoietinOverview · splits 50 ⟂ 60
Thymic stromal lymphopoietinGene · splits 90 ⟂ 20
Thymic stromal lymphopoietinFunction · splits 96 ⟂ 14
Thymic stromal lymphopoietinClinical significance · splits 102 ⟂ 8
Thymic stromal lymphopoietinDiscovery · splits 103 ⟂ 7

Map overview Semantic statistics

Thymic stromal lymphopoietin

Nodes110
Edges109
Triples97
Avg. degree1.98
Density0.018182
Components1

Source & methodology

TTTA analyzes the structure around Thymic stromal lymphopoietin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Gene, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Thymic stromal lymphopoietin · EN edition · Analysis: TopicsToTalkAbout

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