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Drug rash with eosinophilia and systemic symptoms

Drug rash with eosinophilia and systemic symptoms or drug reaction with eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications. It involves primarily a widespread skin rash, fever, swollen lymph nodes, and characteristic blood abnormalities such as an abnormally…

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Causes
Medication exposure
Complications
Kidney damage, liver damage, heart damage, lung damage
Diagnostic method
Clinical diagnosis.
Differential diagnosis
Stevens Johnson syndrome, Toxic epidermal necrolysis, Acute generalized exanthematous pustulosis
Frequency
Incidence 1 case per 1,000 people to 1 case per 10,000 people
Other names
Drug induced hypersensitivity syndrome (DIHS), drug hypersensitivity syndrome (DHS), drug-induced delayed multiorgan hypersensitivity syndrome, drug-induced pseudolymphoma (form…

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Signs and symptoms

Causes

Pathophysiology

Preventative

Treatment

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Drug rash with eosinophilia and systemic symptoms

Nodes176
Edges175
Triples15
Avg. degree1.99
Density0.011364
Components1

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Drug rash with eosinophilia and systemic symptoms

Top relations

Causes · 1
Drug rash with eosinophilia and systemic symptoms → Medication exposure
Complications · 1
Drug rash with eosinophilia and systemic symptoms → Kidney damage, liver damage, heart damage, lung damage
Diagnostic method · 1
Drug rash with eosinophilia and systemic symptoms → Clinical diagnosis.
Differential diagnosis · 1
Drug rash with eosinophilia and systemic symptoms → Stevens Johnson syndrome, Toxic epidermal necrolysis, Acute generalized exanthematous pustulosis
Frequency · 1
Drug rash with eosinophilia and systemic symptoms → Incidence 1 case per 1,000 people to 1 case per 10,000 people
Other names · 1
Drug rash with eosinophilia and systemic symptoms → Drug induced hypersensitivity syndrome (DIHS), drug hypersensitivity syndrome (DHS), drug-induced delayed multiorgan hypersensitivity syndrome, drug-induced pseudolymphoma (form…
Prognosis · 1
Drug rash with eosinophilia and systemic symptoms → Mortality rate varies, generally 1.2-7.1%, long term complications or disability is common
Risk factors · 1
Drug rash with eosinophilia and systemic symptoms → Certain Human leukocyte antigen variants confer a greater risk after medication exposure
Specialty · 1
Drug rash with eosinophilia and systemic symptoms → Dermatology, Immunology
Symptoms · 1
Drug rash with eosinophilia and systemic symptoms → Rash, fever, sore throat, lymph node swelling, sores in mouth or other mucosal surfaces, facial swelling, itching

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Important terminology

dress syndrome individuals drug treatment scars medications developing response cells t-cell hla expressing disorder also certain allopurinol include rash serotypes

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Drug rash with eosinophilia and systemic symptomsCausesMedication exposure1.00infobox
Drug rash with eosinophilia and systemic symptomsComplicationsKidney damage, liver damage, heart damage, lung damage1.00infobox
Drug rash with eosinophilia and systemic symptomsDiagnostic methodClinical diagnosis.1.00infobox
Drug rash with eosinophilia and systemic symptomsDifferential diagnosisStevens Johnson syndrome, Toxic epidermal necrolysis, Acute generalized exanthematous pustulosis1.00infobox
Drug rash with eosinophilia and systemic symptomsFrequencyIncidence 1 case per 1,000 people to 1 case per 10,000 people1.00infobox
Drug rash with eosinophilia and systemic symptomsOther namesDrug induced hypersensitivity syndrome (DIHS), drug hypersensitivity syndrome (DHS), drug-induced delayed multiorgan hypersensitivity syndrome, drug-induced pseudolymphoma (form…1.00infobox
Drug rash with eosinophilia and systemic symptomsPrognosisMortality rate varies, generally 1.2-7.1%, long term complications or disability is common1.00infobox
Drug rash with eosinophilia and systemic symptomsRisk factorsCertain Human leukocyte antigen variants confer a greater risk after medication exposure1.00infobox
Drug rash with eosinophilia and systemic symptomsSpecialtyDermatology, Immunology1.00infobox
Drug rash with eosinophilia and systemic symptomsSymptomsRash, fever, sore throat, lymph node swelling, sores in mouth or other mucosal surfaces, facial swelling, itching1.00infobox
Drug rash with eosinophilia and systemic symptomsTreatmentDiscontinuing the offending medication, supportive care, glucocorticoids, Anti IL-5 antibodies, immunosuppressants1.00infobox
Drug rash with eosinophilia and systemic symptomsUsual onsetUsually 2-6 weeks after drug exposure1.00infobox

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