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Vancomycin: History & Applications

Vancomycin is a glycopeptide antibiotic medication used to treat certain bacterial infections. It is administered intravenously (injection into a vein) to treat complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus (medications used to treat…

Language: English [EN]
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Vancomycin topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Vancomycin.

Related topics
150
Source areas
12
Connected nodes
162
Extracted relationships
166
Concept neighborhoods
28
Bridge connections
162

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 30 topics
Medical uses · 23 topics
Antibiotic resistance · 21 topics
History · 18 topics
Side effects · 18 topics
Biosynthesis · 15 topics
Routes of administration · 7 topics
Chemistry · 6 topics
Mechanism of action · 5 topics
Therapeutic drug monitoring · 4 topics
Total synthesis · 2 topics
Dosing considerations · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A07AA09 (WHO) J01XA01 (WHO) S01AA28 (WHO)
Bioavailability
Negligible (oral)
CAS Number
1404–90–6 Y
ChEBI
CHEBI:28001 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Dosing considerations

Routes of administration

Therapeutic drug monitoring

Chemistry

Biosynthesis

Total synthesis

Mechanism of action

Antibiotic resistance

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Vancomycin connects Entity context

The extracted context around Vancomycin shows recurring relationship patterns in the source. For example, Vancomycin → Amycolatopsis, Borneo, Bouw, Christian, Conley, Edmund Kornfeld, Eli Lilly, However, Initially, June, Kornfeld's, Lilly's, Marvin Hoehn, Missionary Alliance, Mississippi, One, Reverend William, Streptomyces, The, This Another extracted example is Vancomycin → Agricultural, D-alanyl-D-alanine, Evolution, NAM/NAG-peptide, One, The D-alanyl-D-lactate, The D-alanyl-D-serine, This, Vancomycin-resistant Enterococcus, VISA, VRSA, While. Use these groups to spot repeated connection types before inspecting the individual relationships.

Vancomycin

Top relations

related to history · 22
Vancomycin → Amycolatopsis, Borneo, Bouw, Christian, Conley, Edmund Kornfeld, Eli Lilly, However, Initially, June, Kornfeld's, Lilly's, Marvin Hoehn, Missionary Alliance, Mississippi, One, Reverend William, Streptomyces, The, This
related to Acquired resistance · 12
Vancomycin → Agricultural, D-alanyl-D-alanine, Evolution, NAM/NAG-peptide, One, The D-alanyl-D-lactate, The D-alanyl-D-serine, This, Vancomycin-resistant Enterococcus, VISA, VRSA, While
related to Biosynthesis · 12
Vancomycin → Amycolatopsis, Before, DPG, Hpg, HT, L-tyrosine, NRPS, NRPSs, The, VpsA, VpsB, VpsC
related to Intrinsic resistance · 10
Vancomycin → Clostridium, Erysipelothrix, Gram-positive, Leuconostoc, Most Gram-negative, Most Lactobacillus, Neisseria, Other Gram-positive, Pediococcus, Weissella
related to Total synthesis · 8
Vancomycin → Boger, Both, Dale Boger, David Evans, December, KC Nicolaou, October, The
related to Dosing considerations · 7
Vancomycin → AUC, AUC0-24h/minimal, Bayesian, Dose, MIC, TDM, The
related to Mechanism of action · 7
Vancomycin → D-Ala-D-Ala, D-alanyl-D-alanine, Gram-positive, Peptidoglycan, Specifically, The, Transglycosylation
related to Medical uses · 7
Vancomycin → Centers, Control Practices Advisory Committee, Disease Control Hospital Infection, Gram-positive, The, These, VRE
related to "Regained" vancomycin · 6
Vancomycin → Germany, In, Position VN, The, This, University Hospital Heidelberg
Legal status · 5
Vancomycin → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bacteria used drug cell infections antibiotic resistant wall ototoxicity treatment levels bacterial monitoring infection due peptide use therapeutic gram-positive patients

Vancomycin relationships Subject–Predicate–Object triples

TTTA extracted 166 structured relationships around Vancomycin. Examples in this analysis include Vancomycin → 3D model (JSmol) → Interactive image and Vancomycin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Vancomycin3D model (JSmol)Interactive image1.00infobox
VancomycinAHFS/Drugs.comMonograph1.00infobox
VancomycinATC codeA07AA09 (WHO) J01XA01 (WHO) S01AA28 (WHO)1.00infobox
VancomycinBioavailabilityNegligible (oral)1.00infobox
VancomycinCAS Number1404–90–6 Y1.00infobox
VancomycinChEBICHEBI:28001 Y1.00infobox
VancomycinChEMBLChEMBL262777 Y1.00infobox
VancomycinChemSpider14253 Y1.00infobox
VancomycinCompTox Dashboard (EPA)DTXSID00426641.00infobox
VancomycinDrug classGlycopeptide antibiotic1.00infobox
VancomycinDrugBankDB00512 Y1.00infobox
VancomycinECHA InfoCard100.014.3381.00infobox
VancomycinElimination half-life4 h to 11 h (adults, normal renal function) 6 d to 10 d (adults, impaired renal function)1.00infobox
VancomycinExcretionurine (IV), feces (oral)1.00infobox
VancomycinFormulaC66H75Cl2N9O241.00infobox
VancomycinKEGGD00212 Y1.00infobox
VancomycinKEGGas HCl: D00926 N1.00infobox
VancomycinLegal statusAU: S4 (Prescription only)1.00infobox
VancomycinLegal statusCA: ℞-only1.00infobox
VancomycinLegal statusUK: POM (Prescription only)1.00infobox
VancomycinLegal statusUS: ℞-only1.00infobox
VancomycinLegal statusEU: Rx-only1.00infobox
VancomycinLicense dataEU EMA: by INN1.00infobox
VancomycinLicense dataUS DailyMed: Vancomycin1.00infobox
VancomycinLicense dataUS FDA: Vancomycin1.00infobox
VancomycinMedlinePlusa6040381.00infobox
VancomycinMetabolismExcreted unchanged1.00infobox
VancomycinMolar mass1449.27 g·mol−11.00infobox
VancomycinPregnancy categoryAU: B21.00infobox
VancomycinPronunciation/væŋkəˈmaɪsɪn/1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Vancomycin bring nearby vocabulary together. In this analysis, examples include Wall, Antibiotic and Glycopeptide. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • glycopeptide antibiotic
    • Antibiotic
    • Glycopeptide
    • Recommended
    • Use
    • Infections
    • Side
    • Administration
    • Used
    • Effects
    • Gram-positive
    • Bacteria
    • Intravenous
  • bacterial infections
    • Treat
    • Cell
    • Wall
    • Caused
    • Treatment
    • Oral
    • Used
    • Gram-positive
    • Aureus
    • Side
    • Administration
    • Effects
  • skin infections
    • Treat
    • Caused
    • Treatment
    • Oral
    • Used
    • Gram-positive
    • Aureus
    • Side
    • Administration
    • Effects
    • Also
    • Patients
  • bloodstream infections
    • Treat
    • Caused
    • Treatment
    • Oral
    • Used
    • Gram-positive
    • Aureus
    • Side
    • Administration
    • Effects
    • Also
    • Patients
  • medications used to treat mrsa
    • Infections
    • Treat
    • Used
    • Caused
    • Administration
    • Oral
    • Drug
    • Also
    • Vancomycin
    • Risk
    • Gram-positive
    • Therapeutic
  • clostridioides difficile infections
    • Treat
    • Caused
    • Treatment
    • Oral
    • Used
    • Gram-positive
    • Aureus
    • Side
    • Administration
    • Effects
    • Also
    • Patients
  • therapeutic drug monitoring
    • Therapeutic
    • Monitoring
    • Ototoxicity
    • Risk
    • Nephrotoxicity
    • Used
    • Intravenous
    • Side
    • Vancomycin
    • Serum
    • Patients
    • Treatment
  • empiric antibiotic
    • Glycopeptide
    • Recommended
    • Use
    • Infections
    • Side
    • Administration
    • Used
    • Effects
    • Gram-positive
    • Bacteria
    • Bacterial
    • Due

Connections between topic areas Semantic bridges

For Vancomycin, one of the stronger structural bridges in this analysis connects Vancomycin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Vancomycin — Overview · splits 132 ⟂ 31
Vancomycin — Medical uses · splits 139 ⟂ 24
Vancomycin — Antibiotic resistance · splits 141 ⟂ 22
Vancomycin — Side effects · splits 144 ⟂ 19
Vancomycin — History · splits 144 ⟂ 19
Vancomycin — Biosynthesis · splits 147 ⟂ 16
Vancomycin — Routes of administration · splits 155 ⟂ 8
Vancomycin — Chemistry · splits 156 ⟂ 7
Vancomycin — Mechanism of action · splits 157 ⟂ 6
Vancomycin — Therapeutic drug monitoring · splits 158 ⟂ 5
Vancomycin — Total synthesis · splits 160 ⟂ 3

Map overview Semantic statistics

Vancomycin

Nodes163
Edges162
Triples166
Avg. degree1.99
Density0.01227
Components1

Source & methodology

TTTA analyzes the structure around Vancomycin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Vancomycin · EN edition · Analysis: TopicsToTalkAbout

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