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Vancomycin

Vancomycin is a glycopeptide antibiotic medication used to treat certain bacterial infections. It is administered intravenously (injection into a vein) to treat complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus (medications used to treat…

History & Applications

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A07AA09 (WHO) J01XA01 (WHO) S01AA28 (WHO)
Bioavailability
Negligible (oral)
CAS Number
1404–90–6 Y
ChEBI
CHEBI:28001 Y

Topics to explore

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Overview

Medical uses

Side effects

Dosing considerations

Routes of administration

Therapeutic drug monitoring

Chemistry

Biosynthesis

Total synthesis

Mechanism of action

Antibiotic resistance

History

Advanced semantic analysis

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Map overview Semantic statistics

Vancomycin

Nodes163
Edges162
Triples166
Avg. degree1.99
Density0.01227
Components1

How this topic connects Entity context

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Vancomycin

Top relations

related to history · 22
Vancomycin → Amycolatopsis, Borneo, Bouw, Christian, Conley, Edmund Kornfeld, Eli Lilly, However, Initially, June, Kornfeld's, Lilly's, Marvin Hoehn, Missionary Alliance, Mississippi, One, Reverend William, Streptomyces, The, This
related to Acquired resistance · 12
Vancomycin → Agricultural, D-alanyl-D-alanine, Evolution, NAM/NAG-peptide, One, The D-alanyl-D-lactate, The D-alanyl-D-serine, This, Vancomycin-resistant Enterococcus, VISA, VRSA, While
related to Biosynthesis · 12
Vancomycin → Amycolatopsis, Before, DPG, Hpg, HT, L-tyrosine, NRPS, NRPSs, The, VpsA, VpsB, VpsC
related to Intrinsic resistance · 10
Vancomycin → Clostridium, Erysipelothrix, Gram-positive, Leuconostoc, Most Gram-negative, Most Lactobacillus, Neisseria, Other Gram-positive, Pediococcus, Weissella
related to Total synthesis · 8
Vancomycin → Boger, Both, Dale Boger, David Evans, December, KC Nicolaou, October, The
related to Dosing considerations · 7
Vancomycin → AUC, AUC0-24h/minimal, Bayesian, Dose, MIC, TDM, The
related to Mechanism of action · 7
Vancomycin → D-Ala-D-Ala, D-alanyl-D-alanine, Gram-positive, Peptidoglycan, Specifically, The, Transglycosylation
related to Medical uses · 7
Vancomycin → Centers, Control Practices Advisory Committee, Disease Control Hospital Infection, Gram-positive, The, These, VRE
related to "Regained" vancomycin · 6
Vancomycin → Germany, In, Position VN, The, This, University Hospital Heidelberg
Legal status · 5
Vancomycin → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

bacteria used drug cell infections antibiotic resistant wall ototoxicity treatment levels bacterial monitoring infection due peptide use therapeutic gram-positive patients

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Vancomycin3D model (JSmol)Interactive image1.00infobox
VancomycinAHFS/Drugs.comMonograph1.00infobox
VancomycinATC codeA07AA09 (WHO) J01XA01 (WHO) S01AA28 (WHO)1.00infobox
VancomycinBioavailabilityNegligible (oral)1.00infobox
VancomycinCAS Number1404–90–6 Y1.00infobox
VancomycinChEBICHEBI:28001 Y1.00infobox
VancomycinChEMBLChEMBL262777 Y1.00infobox
VancomycinChemSpider14253 Y1.00infobox
VancomycinCompTox Dashboard (EPA)DTXSID00426641.00infobox
VancomycinDrug classGlycopeptide antibiotic1.00infobox
VancomycinDrugBankDB00512 Y1.00infobox
VancomycinECHA InfoCard100.014.3381.00infobox
VancomycinElimination half-life4 h to 11 h (adults, normal renal function) 6 d to 10 d (adults, impaired renal function)1.00infobox
VancomycinExcretionurine (IV), feces (oral)1.00infobox
VancomycinFormulaC66H75Cl2N9O241.00infobox
VancomycinKEGGD00212 Y1.00infobox
VancomycinKEGGas HCl: D00926 N1.00infobox
VancomycinLegal statusAU: S4 (Prescription only)1.00infobox
VancomycinLegal statusCA: ℞-only1.00infobox
VancomycinLegal statusUK: POM (Prescription only)1.00infobox
VancomycinLegal statusUS: ℞-only1.00infobox
VancomycinLegal statusEU: Rx-only1.00infobox
VancomycinLicense dataEU EMA: by INN1.00infobox
VancomycinLicense dataUS DailyMed: Vancomycin1.00infobox
VancomycinLicense dataUS FDA: Vancomycin1.00infobox
VancomycinMedlinePlusa6040381.00infobox
VancomycinMetabolismExcreted unchanged1.00infobox
VancomycinMolar mass1449.27 g·mol−11.00infobox
VancomycinPregnancy categoryAU: B21.00infobox
VancomycinPronunciation/væŋkəˈmaɪsɪn/1.00infobox

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