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Abacavir

Abacavir (ABC), sold under the brand name Ziagen among others, is a medication used to treat HIV/AIDS. Similar to other nucleoside analog reverse-transcriptase inhibitors (NRTIs), abacavir is used together with other HIV medications, and is not recommended by itself. It is taken by mouth as a tablet or solution and may be used in children over the age of…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J05AF06 (WHO)
Bioavailability
83%
CAS Number
136470-78-5 Y
ChEBI
CHEBI:421707 Y

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Overview

Medical uses

Contraindications

Side effects

Interaction

Mechanism of action

Pharmacokinetics

History

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Map overview Semantic statistics

Abacavir

Nodes93
Edges92
Triples109
Avg. degree1.98
Density0.021505
Components1

How this topic connects Entity context

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Abacavir

Top relations

related to Hypersensitivity syndrome · 28
Abacavir → Additionally, African, AHS, Chinese Americans, Clinical Pharmacogenetics Implementation Consortium, Common, Drug Administration, Dutch Pharmacogenetics Working Group, European, FDA, FDA-approved, Food, Hispanic Americans, HIV, HLA-B, Hypersensitivity, In African Americans, Indian Americans, July, Kenya
related to Interaction · 13
Abacavir → Below, Cabozantinib, CYP, Drugs, Ethanol, Methadone, MRP2, Multidrug, NRTIs, Orlistat, Protease, That, The
related to history · 9
Abacavir → China, December, Drug Administration, FDA, Mei Hua, Robert Vince, Susan Daluge, United States, US Food
related to Mechanism of action · 5
Abacavir → CBV-TP, DNA, HIV, It, Once CBV-TP
Legal status · 4
Abacavir → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Immunopathogenesis · 3
Abacavir → HLA-B, The, This
related to Pharmacokinetics · 3
Abacavir → If, It, Solution
3D model (JSmol) · 1
Abacavir → Interactive image
AHFS/Drugs.com · 1
Abacavir → Monograph
ATC code · 1
Abacavir → J05AF06 (WHO)

Important terminology Word statistics

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Important terminology

hypersensitivity hiv include may used 5701 hla-b side effects allele rash common medications vomiting liver syndrome medication drugs use nucleoside

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Abacavir3D model (JSmol)Interactive image1.00infobox
AbacavirAHFS/Drugs.comMonograph1.00infobox
AbacavirATC codeJ05AF06 (WHO)1.00infobox
AbacavirBioavailability83%1.00infobox
AbacavirCAS Number136470-78-5 Y1.00infobox
AbacavirChEBICHEBI:421707 Y1.00infobox
AbacavirChEMBLChEMBL1380 Y1.00infobox
AbacavirChemSpider390063 Y1.00infobox
AbacavirCompTox Dashboard (EPA)DTXSID40464441.00infobox
AbacavirDrugBankDB01048 Y1.00infobox
AbacavirECHA InfoCard100.149.3411.00infobox
AbacavirElimination half-life1.54 ± 0.63 h1.00infobox
AbacavirExcretionKidney (1.2% abacavir, 30% 5'-carboxylic acid metabolite, 36% 5'-glucuronide metabolite, 15% unidentified minor metabolites). Fecal (16%)1.00infobox
AbacavirFormulaC14H18N6O1.00infobox
AbacavirKEGGD07057 Y1.00infobox
AbacavirLegal statusAU: S4 (Prescription only)1.00infobox
AbacavirLegal statusUK: POM (Prescription only)1.00infobox
AbacavirLegal statusUS: ℞-only1.00infobox
AbacavirLegal statusEU: Rx-only1.00infobox
AbacavirLicense dataUS DailyMed: Abacavir1.00infobox
AbacavirMedlinePlusa6990121.00infobox
AbacavirMelting point165 °C (329 °F)1.00infobox
AbacavirMetabolismLiver1.00infobox
AbacavirMolar mass286.339 g·mol−11.00infobox
AbacavirNIAID ChemDB0285961.00infobox
AbacavirOther namesAbacavir sulfate (USAN US)1.00infobox
AbacavirPregnancy categoryAU: B31.00infobox
AbacavirPronunciation/əˈbækəvɪər/ ⓘ1.00infobox
AbacavirPubChem CID4413001.00infobox
AbacavirRoutes of administrationBy mouth1.00infobox

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