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Telaprevir

Telaprevir (VX-950), was marketed under the brand names Incivek and Incivo, is a pharmaceutical drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson. It is a member of a class of antiviral drugs known as protease inhibitors. Specifically, telaprevir inhibits the hepatitis C viral enzyme NS3/4A serine…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Consumer Drug Information
ATC code
J05AP02 (WHO)
CAS Number
402957-28-2 N
ChEBI
CHEBI:68595 N
ChEMBL
ChEMBL231813 Y

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Overview

Clinical trials and approvals

Adverse effects

Research

Advanced semantic analysis

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Map overview Semantic statistics

Telaprevir

Nodes27
Edges26
Triples61
Avg. degree1.93
Density0.074074
Components1

How this topic connects Entity context

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Telaprevir

Top relations

related to Clinical trials and approvals · 16
Telaprevir → ADVANCE, Committee, FDA Antiviral Drugs Advisory, HCV, III ADVANCE, ILLUMINATE, In, May, Merck's, On April, PROVE3, REALIZE, SVR, The, This, United States
has effect · 11
Telaprevir → After, Drug Administration, FDA, Grade, Incivek, On December, The, The FDA, US, US Food, Vertex
related to Availability · 4
Telaprevir → Incivek, On August, The, Vertex Pharmaceuticals
related to Research · 4
Telaprevir → AFM, D68, Since, Studies
3D model (JSmol) · 1
Telaprevir → Interactive image
AHFS/Drugs.com · 1
Telaprevir → Consumer Drug Information
ATC code · 1
Telaprevir → J05AP02 (WHO)
CAS Number · 1
Telaprevir → 402957-28-2 N
ChEBI · 1
Telaprevir → CHEBI:68595 N
ChEMBL · 1
Telaprevir → ChEMBL231813 Y

Important terminology Word statistics

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Important terminology

hepatitis svr therapy ribavirin patients treatment genotype incivek drug vertex viral fda drugs trial peginterferon response antiviral use standard protease

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Telaprevir3D model (JSmol)Interactive image1.00infobox
TelaprevirAHFS/Drugs.comConsumer Drug Information1.00infobox
TelaprevirATC codeJ05AP02 (WHO)1.00infobox
TelaprevirCAS Number402957-28-2 N1.00infobox
TelaprevirChEBICHEBI:68595 N1.00infobox
TelaprevirChEMBLChEMBL231813 Y1.00infobox
TelaprevirChemSpider2279948 Y1.00infobox
TelaprevirCompTox Dashboard (EPA)DTXSID401933041.00infobox
TelaprevirDrugBankDB05521 N1.00infobox
TelaprevirECHA InfoCard100.129.8571.00infobox
TelaprevirElimination half-life9–11 hours1.00infobox
TelaprevirExcretion90% (bile), 9% (exhaled air), 1% (urine)1.00infobox
TelaprevirFormulaC36H53N7O61.00infobox
TelaprevirIUPHAR/BPS78711.00infobox
TelaprevirKEGGD09012 Y1.00infobox
TelaprevirLegal statusUS: ℞-only1.00infobox
TelaprevirLicense dataUS FDA: Telaprevir1.00infobox
TelaprevirMedlinePlusa6110381.00infobox
TelaprevirMetabolismextensive hepatic1.00infobox
TelaprevirMolar mass679.863 g·mol−11.00infobox
TelaprevirNIAID ChemDB2130061.00infobox
TelaprevirProtein binding59–76%1.00infobox
TelaprevirPubChem CID30108181.00infobox
TelaprevirRoutes of administrationOral1.00infobox
TelaprevirTrade namesIncivek, Incivo1.00infobox
TelaprevirUNII655M5O3W0U1.00infobox

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