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Genome editing

Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism. Unlike early genetic engineering techniques that randomly insert genetic material into a host genome, genome editing targets the insertions to site-specific locations.

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Overview

History

Background

Process

Precision and efficiency of engineered nucleases

Multiplex Automated Genomic Engineering (MAGE)

Applications

Research

Prospects and limitations

Risks

Nobel prize

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Genome editing

Nodes169
Edges168
Triples234
Avg. degree1.99
Density0.011834
Components1

How this topic connects Entity context

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Genome editing

Top relations

related to Further reading · 33
Genome editing → Academic Press, April, B978-0-443-19045-2, Bioethics, Chapter, Clinical Ethics At, Connor, Crop Improvement, Crossroads, Customized Human Genes, Daniela, From, Genetic, Genomic, Human Germline Editing, Iancu, In Hostiuc, ISBN, March, New Promises
related to Targeted gene modification in plants · 25
Genome editing → Arabidopsis, Calyxt, CRISPR/Cas9, For, Genome, In, In Arabidopsis, In Zea, IPK1, Meganuclease, Musa, NHEJ, PAT, Progress, Such, SuR, SuRA, SuRB, TALEN, TALEN-based
related to Risks · 23
Genome editing → According, Australia, Australian, Bioethics, Clapper, CRISPR, For, Furthermore, Ian Ramshaw, In, James, Journal, National Intelligence, Nuffield Council, Ronald Jackson, September, Such, The, United States Director, US Intelligence Community
related to Human enhancement · 16
Genome editing → According, Alzheimer's, Australian, Bioethics, February, Genetics David Andrew Sinclair, George Church, Many, Medicine, National Academy, Nuffield Council, Professor, Sciences, September, The American National Academy, They
related to Multiplex Automated Genomic Engineering (MAGE) · 14
Genome editing → By, Chemically, DNA, Each, Experiments, Harvard University, It, MAGE, Prior, The, There, Therefore, Those, Wyss Institute
related to history · 13
Genome editing → All, As, Breakthrough, CRISPR-Cas, Genome, In, Method, Nature Methods, Nine, Science, TALEN, Year, ZFNs
related to Targeted gene modification in animals · 13
Genome editing → Atlantic, Cas9, CDI, CRISPR/Cas9, Furthermore, Gene, In, Knockouts, KO, RNA-guided, RNAs, Selecting, The
related to Engineered nucleases · 11
Genome editing → Clustered, Commonly, CRISPR/Cas9, DNA, DSB, MeganucleasesZinc, TALEN, The, To, Transcription-activator, ZFNs
related to Nobel prize · 10
Genome editing → Chemistry, Emmanuelle Charpentier, In, Jennifer Doudna, Mario Capecchi, Martin Evans, Medicine, Nobel Prize, Oliver Smithies, Physiology
has application · 8
Genome editing → As, For, Genome, In, Listed, TALEN-based, The, ZFN-mediated

Important terminology Word statistics

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Important terminology

genome dna editing gene crispr nucleases used specific sequence talen proteins sequences genetic zinc human engineered genes cells one methods

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Zinc finger nucleaseinstance ofa severe monogenic disorder that predisposes the patients to skin cancer and burns whenever their skin is exposed to UV rays.Meganucleases have the benefit of causing less toxic…0.80text
transcription factorsinstance ofCys2-His2 Zinc fingers typically happen in repeats that are 3 bp apart and are found in diverse combinations in a variety of nucleic acid interacting proteins0.80text
modular assemblyinstance ofZinc fingers have been more established in these terms and approaches0.80text
sequence insertioninstance offor gene editing applications that enable to perform targeted genome modifications0.80text
deletioninstance offor gene editing applications that enable to perform targeted genome modifications0.80text
repairinstance offor gene editing applications that enable to perform targeted genome modifications0.80text
replacement in living cellsinstance offor gene editing applications that enable to perform targeted genome modifications0.80text
zinc fingersinstance ofwhich can then be linked to specific DNA sequence recognizing peptides0.80text
transcription activator-like effectorsinstance ofwhich can then be linked to specific DNA sequence recognizing peptides0.80text
Atlantic salmoninstance ofgene editing can be applied to certain types of fish in aquaculture0.80text
Down syndromeinstance ofand to evade detection by the host immune system after introduction.Extensive research has been done in cells and animals using CRISPR-Cas9 to attempt to correct genetic mutatio…0.80text
spina bifidainstance ofand to evade detection by the host immune system after introduction.Extensive research has been done in cells and animals using CRISPR-Cas9 to attempt to correct genetic mutatio…0.80text

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