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HRAS: Function, Clinical significance & Overview

GTPase HRas, also known as the "Harvey Rat sarcoma viral oncogene homolog" and transforming protein p21, is an enzyme that is encoded by the HRAS gene in humans. The HRAS gene is located on the short (p) arm of chromosome 11 at position 15.5, from base pair 522,241 to base pair 525,549. HRas is a small G protein in the Ras subfamily of the Ras…

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HRAS topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around HRAS.

Related topics
44
Source areas
3
Connected nodes
47
Extracted relationships
185
Concept neighborhoods
21
Bridge connections
47

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 18 topics
Function · 16 topics
Clinical significance · 10 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.5.2
Aliases
HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase, RASK2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R,…
Band
11p15.5 · 7 F5|7 86.48 cM
Bgee
skin of abdomen · skin of leg · putamen · caudate nucleus · nucleus accumbens
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HRAS connects Entity context

The extracted context around HRAS shows recurring relationship patterns in the source. For example, HRAS → animal organ morphogenesis, apoptotic process, cell population proliferation, cell surface receptor signaling pathway, cellular response to gamma radiation, cellular senescence, chemotaxis, cytoplasm, cytosol, defense response to protozoan, endocytosis, ephrin receptor signaling pathway, GDP binding, glutamatergic synapse, Golgi apparatus, Golgi membrane, GTP binding, GTPase activity, intracellular membrane-bounded organelle, intrinsic apoptotic signaling pathway Another extracted example is HRAS → C-terminus, GAP, GDP, GEF, Growth, GTP, GTPase, GTPase HRas, GTPase-activating, HRAS-GTP, KRAS, NRAS, Once, PI, Raf, Ras, RasGAP, SOS1, Subsequently, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

HRAS

Top relations

Gene ontology · 63
HRAS → animal organ morphogenesis, apoptotic process, cell population proliferation, cell surface receptor signaling pathway, cellular response to gamma radiation, cellular senescence, chemotaxis, cytoplasm, cytosol, defense response to protozoan, endocytosis, ephrin receptor signaling pathway, GDP binding, glutamatergic synapse, Golgi apparatus, Golgi membrane, GTP binding, GTPase activity, intracellular membrane-bounded organelle, intrinsic apoptotic signaling pathway
related to Function · 23
HRAS → C-terminus, GAP, GDP, GEF, Growth, GTP, GTPase, GTPase HRas, GTPase-activating, HRAS-GTP, KRAS, NRAS, Once, PI, Raf, Ras, RasGAP, SOS1, Subsequently, The
Bgee · 20
HRAS → amygdala, caudate nucleus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, esophagus, fetal liver hematopoietic progenitor cell, hypothalamus, lip, molar, muscle of thigh, nucleus accumbens, perirhinal cortex, putamen, right hemisphere of cerebellum, skin of abdomen, skin of leg, substantia nigra, superior frontal gyrus, temporal lobe, yolk sac
RNA expression pattern · 20
HRAS → amygdala, caudate nucleus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, esophagus, fetal liver hematopoietic progenitor cell, hypothalamus, lip, molar, muscle of thigh, nucleus accumbens, perirhinal cortex, putamen, right hemisphere of cerebellum, skin of abdomen, skin of leg, substantia nigra, superior frontal gyrus, temporal lobe, yolk sac
related to Bladder cancer · 12
HRAS → G12V, Gly12Val, H-RasV12, Mutations, One, Somatic, Some, Specifically, The, These, This, When
related to Costello syndrome · 9
HRAS → At, Costello, Each, G12S, Gly12Ser, Instead, Researchers, The, This
related to External links · 5
HRAS → Costello, GeneReviews/NCBI/NIH/UW, Medicine Medical Subject Headings, MeSH, National Library
related to Other cancers · 5
HRAS → DNA, Recent, Somatic, The HRAS, These
Band · 2
HRAS → 11p15.5, 7 F5|7 86.48 cM
Chr. · 2
HRAS → Chromosome 11 (human), Chromosome 7 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene mutations protein cell cellular virus bp human chromosome 11 gtpase chr band oncogene cells growth costello syndrome cancer harvey

HRAS relationships Subject–Predicate–Object triples

TTTA extracted 185 structured relationships around HRAS. Examples in this analysis include HRAS → 3.6.5.2 → ↗ and HRAS → Aliases → HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase, RASK2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HRAS3.6.5.21.00infobox
HRASAliasesHRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase, RASK21.00infobox
HRASAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R,…1.00infobox
HRASBand11p15.51.00infobox
HRASBand7 F5|7 86.48 cM1.00infobox
HRASBgeeskin of abdomen1.00infobox
HRASBgeeskin of leg1.00infobox
HRASBgeeputamen1.00infobox
HRASBgeecaudate nucleus1.00infobox
HRASBgeenucleus accumbens1.00infobox
HRASBgeehypothalamus1.00infobox
HRASBgeetemporal lobe1.00infobox
HRASBgeeamygdala1.00infobox
HRASBgeeright hemisphere of cerebellum1.00infobox
HRASBgeesubstantia nigra1.00infobox
HRASBgeedentate gyrus of hippocampal formation granule cell1.00infobox
HRASBgeelip1.00infobox
HRASBgeemolar1.00infobox
HRASBgeesuperior frontal gyrus1.00infobox
HRASBgeeesophagus1.00infobox
HRASBgeefetal liver hematopoietic progenitor cell1.00infobox
HRASBgeeyolk sac1.00infobox
HRASBgeeentorhinal cortex1.00infobox
HRASBgeeperirhinal cortex1.00infobox
HRASBgeemuscle of thigh1.00infobox
HRASBioGPSMore reference expression data1.00infobox
HRASChr.Chromosome 11 (human)1.00infobox
HRASChr.Chromosome 7 (mouse)1.00infobox
HRASDatabasesNCBI: entry; OMA: entry1.00infobox
HRASEnd537,321 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HRAS bring nearby vocabulary together. In this analysis, examples include Protein, Mutations and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HRAS
    • Protein
    • Mutations
    • Cancer
    • Costello
    • Syndrome
    • Bladder
    • Gtp
    • Cell
    • Gdp
    • Ras
    • Signal
    • Chromosome
  • hras
    • Protein
    • Mutations
    • Cancer
    • Costello
    • Syndrome
    • Bladder
    • Gtp
    • Cell
    • Gdp
    • Ras
    • Signal
    • Chromosome
  • gene
    • Virus
    • Hras
    • Mutations
    • Cancer
    • Chromosome
    • Cellular
    • Harvey
    • Location
    • Oncogene
    • Rat
    • Sarcoma
    • Viral
  • chromosome 11
    • Bp
    • Chr
    • Human
    • Location
    • Band
    • Gtpase
    • Gene
    • Gdp
    • Harvey
    • Oncogene
    • Position
    • Proto-oncogene
  • small g protein
    • Cell
    • Divide
    • Grow
    • Cells
    • Ras
    • Mutations
    • Acid
    • Amino
    • Signal
    • Costello
    • Growth
    • Human
  • gtpase
    • Harvey
    • Location
    • Oncogene
    • Rat
    • Sarcoma
    • Viral
    • Signal
    • Bp
    • Chr
    • Chromosome
    • Human
    • Protein
  • cell membranes
    • Growth
    • Divide
    • Grow
    • Protein
    • Signal
    • Gtpase
    • Proteins
    • Gene
    • Hras
    • Cancerous
    • Gdp
    • Location
  • bladder cancer
    • Cancer
    • Gene
    • Cells
    • Mutations
    • Hras
    • Harvey
    • Location
    • Oncogene
    • Proto-oncogene
    • Rat
    • Sarcoma
    • Viral

Connections between topic areas Semantic bridges

For HRAS, one of the stronger structural bridges in this analysis connects HRAS with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HRASOverview · splits 29 ⟂ 19
HRASFunction · splits 31 ⟂ 17
HRASClinical significance · splits 37 ⟂ 11

Map overview Semantic statistics

HRAS

Nodes48
Edges47
Triples185
Avg. degree1.96
Density0.041667
Components1

Source & methodology

TTTA analyzes the structure around HRAS to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HRAS · EN edition · Analysis: TopicsToTalkAbout

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